Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
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Olafsdottir BR, Rye DB, Scammell TE, Matheson JK, Stefansson K, Gulcher JR
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
Neurology. 2001 Nov 27;57(10):1896-9.
- PubMed ID
- 11723285 [ View in PubMed]
- Abstract
The neuroexcitatory peptide hypocretin and its receptors are central to the pathophysiology of both human and animal models of the disease. In this study of American and Icelandic patients with narcolepsy, the authors found no significant association between narcolepsy and single-nucleotide polymorphisms in the genes for hypocretin or its two known receptors, hypocretin receptor-1 and hypocretin receptor-2.