Tetracycline resistance protein, class C

Details

Name
Tetracycline resistance protein, class C
Synonyms
  • TetA(C)
Gene Name
tetA
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0051992|Tetracycline resistance protein, class C
MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCA
PVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYI
ADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFL
MQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDR
FRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRG
WMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYA
ASASTWNGLAWIVGAALYLVCLPALRRGAWSRATST
Number of residues
396
Molecular Weight
41509.665
Theoretical pI
Not Available
GO Classification
Functions
antiporter activity
Processes
ion transport / response to antibiotic
Components
integral component of membrane / plasma membrane
General Function
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.
Specific Function
Antiporter activity
Pfam Domain Function
Transmembrane Regions
7-27 46-66 80-100 104-124 139-159 161-181 211-231 247-267 278-298 300-320 340-360 365-385
Cellular Location
Cell inner membrane
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP02981
UniProtKB Entry NameTCR3_ECOLX
General References
  1. Sutcliffe JG: Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol. 1979;43 Pt 1:77-90. [Article]
  2. Livneh Z: Directed mutagenesis method for analysis of mutagen specificity: application to ultraviolet-induced mutagenesis. Proc Natl Acad Sci U S A. 1983 Jan;80(1):237-41. [Article]
  3. Peden KW: Revised sequence of the tetracycline-resistance gene of pBR322. Gene. 1983 May-Jun;22(2-3):277-80. [Article]
  4. Allard JD, Bertrand KP: Membrane topology of the pBR322 tetracycline resistance protein. TetA-PhoA gene fusions and implications for the mechanism of TetA membrane insertion. J Biol Chem. 1992 Sep 5;267(25):17809-19. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails