Tetracycline resistance protein, class C
Details
- Name
- Tetracycline resistance protein, class C
- Synonyms
- TetA(C)
- Gene Name
- tetA
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0051992|Tetracycline resistance protein, class C MKSNNALIVILGTVTLDAVGIGLVMPVLPGLLRDIVHSDSIASHYGVLLALYALMQFLCA PVLGALSDRFGRRPVLLASLLGATIDYAIMATTPVLWILYAGRIVAGITGATGAVAGAYI ADITDGEDRARHFGLMSACFGVGMVAGPVAGGLLGAISLHAPFLAAAVLNGLNLLLGCFL MQESHKGERRPMPLRAFNPVSSFRWARGMTIVAALMTVFFIMQLVGQVPAALWVIFGEDR FRWSATMIGLSLAVFGILHALAQAFVTGPATKRFGEKQAIIAGMAADALGYVLLAFATRG WMAFPIMILLASGGIGMPALQAMLSRQVDDDHQGQLQGSLAALTSLTSITGPLIVTAIYA ASASTWNGLAWIVGAALYLVCLPALRRGAWSRATST
- Number of residues
- 396
- Molecular Weight
- 41509.665
- Theoretical pI
- Not Available
- GO Classification
- Functionsantiporter activityProcessesion transport / response to antibioticComponentsintegral component of membrane / plasma membrane
- General Function
- Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.
- Specific Function
- Antiporter activity
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 7-27 46-66 80-100 104-124 139-159 161-181 211-231 247-267 278-298 300-320 340-360 365-385
- Cellular Location
- Cell inner membrane
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P02981 UniProtKB Entry Name TCR3_ECOLX - General References
- Sutcliffe JG: Complete nucleotide sequence of the Escherichia coli plasmid pBR322. Cold Spring Harb Symp Quant Biol. 1979;43 Pt 1:77-90. [Article]
- Livneh Z: Directed mutagenesis method for analysis of mutagen specificity: application to ultraviolet-induced mutagenesis. Proc Natl Acad Sci U S A. 1983 Jan;80(1):237-41. [Article]
- Peden KW: Revised sequence of the tetracycline-resistance gene of pBR322. Gene. 1983 May-Jun;22(2-3):277-80. [Article]
- Allard JD, Bertrand KP: Membrane topology of the pBR322 tetracycline resistance protein. TetA-PhoA gene fusions and implications for the mechanism of TetA membrane insertion. J Biol Chem. 1992 Sep 5;267(25):17809-19. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details