Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.22.29
- P2A
- Gene Name
- Not Available
- UniProtKB Entry
- P03303Swiss-Prot
- Organism
- HRV-14
- NCBI Taxonomy ID
- 12131
- Amino acid sequence
>lcl|BSEQ0017078|Genome polyprotein MGAQVSTQKSGSHENQNILTNGSNQTFTVINYYKDAASTSSAGQSLSMDPSKFTEPVKDL MLKGAPALNSPNVEACGYSDRVQQITLGNSTITTQEAANAVVCYAEWPEYLPDVDASDVN KTSKPDTSVCRFYTLDSKTWTTGSKGWCWKLPDALKDMGVFGQNMFFHSLGRSGYTVHVQ CNATKFHSGCLLVVVIPEHQLASHEGGNVSVKYTFTHPGERGIDLSSANEVGGPVKDVIY NMNGTLLGNLLIFPHQFINLRTNNTATIVIPYINSVPIDSMTRHNNVSLMVIPIAPLTVP TGATPSLPITVTIAPMCTEFSGIRSKSIVPQGLPTTTLPGSGQFLTTDDRQSPSALPNYE PTPRIHIPGKVHNLLEIIQVDTLIPMNNTHTKDEVNSYLIPLNANRQNEQVFGTNLFIGD GVFKTTLLGEIVQYYTHWSGSLRFSLMYTGPALSSAKLILAYTPPGARGPQDRREAMLGT HVVWDIGLQSTIVMTIPWTSGVQFRYTDPDTYTSAGFLSCWYQTSLILPPETTGQVYLLS FISACPDFKLRLMKDTQTISQTVALTEGLGDELEEVIVEKTKQTVASISSGPKHTQKVPI LTANETGATMPVLPSDSIETRTTYMHFNGSETDVECFLGRAACVHVTEIQNKDATGIDNH REAKLFNDWKINLSSLVQLRKKLELFTYVRFDSEYTILATASQPDSANYSSNLVVQAMYV PPGAPNPKEWDDYTWQSASNPSVFFKVGDTSRFSVPYVGLASAYNCFYDGYSHDDAETQY GITVLNHMGSMAFRIVNEHDEHKTLVKIRVYHRAKHVEAWIPRAPRALPYTSIGRTNYPK NTEPVIKKRKGDIKSYGLGPRYGGIYTSNVKIMNYHLMTPEDHHNLIAPYPNRDLAIVST GGHGAETIPHCNCTSGVYYSTYYRKYYPIICEKPTNIWIEGNPYYPSRFQAGVMKGVGPA EPGDCGGILRCIHGPIGLLTAGGSGYVCFADIRQLECIAEEQGLSDYITGLGRAFGVGFT DQISTKVTELQEVAKDFLTTKVLSKVVKMVSALVIICRNHDDLVTVTATLALLGCDGSPW RFLKMYISKHFQVPYIERQANDGWFRKFNDACNAAKGLEWIANKISKLIEWIKNKVLPQA KEKLEFCSKLKQLDILERQITTMHISNPTQEKREQLFNNVLWLEQMSQKFAPLYAVESKR IRELKNKMVNYMQFKSKQRIEPVCVLIHGTPGSGKSLTTSIVGRAIAEHFNSAVYSLPPD PKHFDGYQQQEVVIMDDLNQNPDGQDISMFCQMVSSVDFLPPMASLDNKGMLFTSNFVLA STNSNTLSPPTILNPEALVRRFGFDLDICLHTTYTKNGKLNAGMSTKTCKDCHQPSNFKK CCPLVCGKAISLVDRTTNIRYSVDQLVTAIISDFKSKMQITDSLETLFQGPVYKDLEIDV CNTPPPECINDLLKSVDSEEIREYCKKKKWIIPEIPTNIERAMNQASMIINTILMFVSTL GIVYVIYKLFAQTQGPYSGNPPHNKLKAPTLRPVVVQGPNTEFALSLLRKNIMTITTSKG EFTGLGIHDRVCVIPTHAQPGDDVLVNGQKIRVKDKYKLVDPENINLELTVLTLDRNEKF RDIRGFISEDLEGVDATLVVHSNNFTNTILEVGPVTMAGLINLSSTPTNRMIRYDYATKT GQCGGVLCATGKIFGIHVGGNGRQGFSAQLKKQYFVEKQGQVIARHKVREFNINPVNTPT KSKLHPSVFYDVFPGDKEPAVLSDNDPRLEVKLTESLFSKYKGNVNTEPTENMLVAVDHY AGQLLSLDIPTSELTLKEALYGVDGLEPIDITTSAGFPYVSLGIKKRDILNKETQDTEKM KFYLDKYGIDLPLVTYIKDELRSVDKVRLGKSRLIEASSLNDSVNMRMKLGNLYKAFHQN PGVLTGSAVGCDPDVFWSVIPCLMDGHLMAFDYSNFDASLSPVWFVCLEKVLTKLGFAGS SLIQSICNTHHIFRDEIYVVEGGMPSGCSGTSIFNSMINNIIIRTLILDAYKGIDLDKLK ILAYGDDLIVSYPYELDPQVLATLGKNYGLTITPPDKSETFTKMTWENLTFLKRYFKPDQ QFPFLVHPVMPMKDIHESIRWTKDPKNTQDHVRSLCMLAWHSGEKEYNEFIQKIRTTDIG KCLILPEYSVLRRRWLDLF
- Number of residues
- 2179
- Molecular Weight
- 242989.38
- Theoretical pI
- 7.28
- GO Classification
- FunctionsATP binding / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA helicase activity / RNA-directed RNA polymerase activity / structural molecule activityProcessesDNA replication / endocytosis involved in viral entry into host cell / induction by virus of host autophagy / lysis of host organelle involved in viral entry into host cell / pore formation by virus in membrane of host cell / pore-mediated entry of viral genome into host cell / positive stranded viral RNA replication / protein oligomerization / RNA-protein covalent cross-linking / suppression by virus of host gene expression / suppression by virus of host mRNA export from nucleus / suppression by virus of host RIG-I activity by RIG-I proteolysis / suppression by virus of host translation initiation factor activity / transcription, DNA-templated / viral RNA genome replication / virion attachment to host cellComponentshost cell cytoplasmic vesicle membrane / integral to membrane of host cell / membrane / T=pseudo3 icosahedral viral capsid
- General Function
- Capsid protein VP1 Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome (By similarity). Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host ICAM1 to provide virion attachment to target host cells (PubMed:10562537). This attachment induces virion internalization (By similarity). Tyrosine kinases are probably involved in the entry process. After binding to its receptor, the capsid undergoes conformational changes (By similarity). Capsid protein VP1 N-terminus (that contains an amphipathic alpha-helix) and capsid protein VP4 are externalized (Probable). Together, they shape a pore in the host membrane through which viral genome is translocated to host cell cytoplasm (PubMed:28696310). After genome has been released, the channel shrinks.
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0017079|Genome polyprotein ATGGGCGCTCAGGTTTCTACACAGAAAAGTGGATCTCACGAAAATCAAAACATTTTGACC AATGGATCAAATCAGACTTTCACAGTTATAAATTACTATAAGGATGCAGCAAGTACATCA TCAGCTGGTCAATCACTGTCAATGGACCCATCTAAGTTTACAGAACCAGTTAAAGATCTC ATGCTTAAGGGTGCACCAGCATTGAATTCACCCAATGTTGAGGCCTGTGGTTATAGTGAT AGAGTACAACAAATCACACTCGGGAATTCAACAATAACAACACAAGAAGCAGCCAACGCT GTTGTGTGTTATGCTGAATGGCCAGAGTACCTTCCAGATGTGGACGCTAGTGATGTCAAT AAAACTTCAAAACCAGACACTTCTGTCTGTAGGTTTTACACATTGGATAGTAAGACATGG ACAACAGGTTCTAAAGGCTGGTGCTGGAAATTACCAGATGCACTCAAGGATATGGGTGTG TTCGGGCAAAACATGTTTTTCCACTCACTAGGAAGATCAGGTTACACAGTACACGTTCAG TGCAATGCCACAAAATTCCATAGCGGTTGTCTACTTGTAGTTGTAATACCAGAACACCAA CTGGCTTCACATGAGGGTGGCAATGTTTCAGTTAAATACACATTCACGCATCCAGGTGAA CGTGGTATAGATTTATCATCTGCAAATGAAGTGGGAGGGCCTGTCAAGGATGTCATATAC AATATGAATGGTACTTTATTAGGAAATCTGCTCATTTTCCCTCACCAGTTCATTAATCTA AGAACCAATAATACAGCCACAATAGTGATACCATACATAAACTCAGTACCCATTGATTCA ATGACACGTCACAACAATGTCTCACTGATGGTCATCCCTATTGCCCCTCTTACAGTACCA ACTGGAGCAACTCCCTCACTCCCTATAACAGTCACAATAGCACCTATGTGCACTGAGTTC TCTGGGATAAGGTCCAAGTCAATTGTGCCACAAGGTTTGCCAACTACAACTTTGCCGGGG TCAGGACAATTCTTGACCACAGATGACAGGCAATCCCCCAGTGCACTGCCAAATTATGAG CCAACTCCAAGAATACACATACTAGGGAAAGTTCATAACTTGCTAGAAATTATACAGGTA GATACACTCATTCCTATGAACAACACGCATACAAAAGATGAGGTTAACAGTTACCTCATA CCACTAAATGCAAACAGGCAAAATGAGCAGGTTTTTGGGACAAACCTGTTTATTGGTGAT GGGGTCTTCAAAACTACTCTTCTGGGTGAAATTGTTCAGTACTATACACATTGGTCTGGA TCACTTAGATTCTCTTCGATGTATACTGGTCCTGCCTTGTCCAGTGCTAAACTCACTCTA GCATACACCCCGCCTGGTGCTCGTGGTCCACAGGACAGGAGAGAAGCAATGCTAGGTACT CATGTTGTCTGGGATATTGGTCTGCAATCCACCATAGTAATGACAATACCATGGACATCA GGGGTGCAGTTTAGATATACTGATCCAGATACATACACCAGTGCTGGCTTTCTATCATGT TGGTATCAAACTTCTCTTATACTTCCCCCAGAAACGACCGGCCAGGTCTACTTATTATCA TTCATAAGTGCATGTCCAGATTTTAAGCTTAGGCTGATGAAAGATACTCAAACTATCTCA CAGACTGTTGCACTCACTGAAGGCTTAGGTGATGAATTAGAAGAAGTCATCGTTGAGAAA ACGAAACAGACGGTGGCCTCAATCTCATCTGGTCCAAAACACACACAAAAAGTCCCCATA CTAACTGCAAACGAAACAGGGGCCACAATGCCTGTTCTTCCATCAGACAGCATAGAAACC AGAACTACCTACATGCACTTTAATGGTTCAGAAACTGATGTAGAATGCTTTTTGGGTCGT GCAGCTTGTGTGCATGTAACTGAAATACAAAACAAAGATGCTACTGGAATAGATAATCAC AGAGAAGCAAAATTGTTCAATGATTGGAAAATCAACCTGTCCAGCCTTGTCCAACTTAGA AAGAAACTGGAACTCTTCACTTATGTTAGGTTTGATTCTGAGTATACCATACTGGCCACT GCATCTCAACCTGATTCAGCAAACTATTCAAGCAATTTGGTGGTCCAAGCCATGTATGTT CCACATGGTGCCCCGAAATCCAAAAGAGTGGGCGATTACACATGGCAAAGTGCTTCAAAC CCCAGTGTATTCTTCAAGGTGGGGGATACATCAAGGTTTAGTGTGCCTTATGTAGGATTG GCATCAGCATATAATTGTTTTTATGATGGTTACTCACATGATGATGCAGAAACTCAGTAT GGCATAACTGTTCTAAACCATATGGGTAGTATGGCATTCAGAATAGTAAATGAACATGAT GAACACAAAACTCTTGTCAAGATCAGAGTTTATCACAGGGCAAAGCTCGTTGAAGCATGG ATTCCAAGAGCACCCAGAGCACTACCCTACACATCAATAGGGCGCACAAATTATCCTAAG AATACAGAACCAGTAATTAAGAAGAGGAAAGGTGACATTAAATCCTATGGTTTAGGACCT AGGTACGGTGGGATTTATACATCAAATGTTAAAATAATGAATTACCACTTGATGACACCA GAAGACCACCATAATCTGATAGCACCCTATCCAAATAGAGATTTAGCAATAGTCTCAACA GGAGGACATGGTGCAGAAACAATACCACACTGTAACCGTACATCAGGTGTTTACTATTCC ACATATTACAGAAAGTATTACCCCATAATTTGCGAAAAGCCCACCAACATCTGGATTGAA GGAAGCCCTTATTACCCAAGTAGATTTCAAGCAGGAGTGATGAAAGGGGTTGGGCCGGCA GAGCTAGGAGACTGCGGTGGGATTTTGAGATGCATACATGGTCCCATTGGATTGTTAACA GCTGAAGGTAGTGGATATGTTTGTTTTGCTGACATACGACAGTTGGAGTGTATCGCAGAG GAACAGGGGCTGAGTGATTACATCACAGGTTTGGGTAGAGCTTTTGGTGTCGGGTTCACT GACCAAATCTCAACAAAAGTCACAGAACTACAAGAAGTGGCGAAAGATTTCCTCACCACA AAAGTTTTGTCCAAAGTGGTCAAAATGGTTTCAGCTTTAGTGATCATTTGCAGAAATCAT GATGACTTGGTCACTGTTACGGCCACTCTAGCACTACTTGGATGTGATGGATCTCCTTGG AGATTTCTGAAGATGTACATTTCCAAACACTTTCAGGTGCCTTACATTGAAAGACAAGCA AATGATGGATGGTTCAGAAAGTTTAATGATGCATGTAATGCTGCAAAGGGATTGGAATGG ATTGCTAATAAGATTTCCAAACTGATTGAATGGATAAAAAACAAAGTACTTCCCCAAGCC AAAGAAAAACTAGAATTTTGTAGTAAACTCAAACAACTTGATATACTAGAGAGACAAATA ACCACCATGCATATCTCGAATCCAACACAGGAAAAACGAGAGCAGTTGTTCAATAACGTA TTGTGGTTGGAACAAATGTCGCAAAAGTTTGCCCCATTTTATGCCGTTGAATCAAAAAGA ATCAGGGAACTCAAGAACAAAATGGTAAATTATATGCAATTTAAAAGTAAACAAAGAACT GAACCAGTGTGTGTATTAATCCATGGTACACCCGGTTCTGGTAAATCATTAACAACATCC ATTGTGGGACGTGCAATTGCAGAACACTTCAATTCAGCAGTATATTCACTTCCACCAGAT CCCAAGCACTTTGATGGTTATCAGCAACAGGAAGTTGTGATTATGGATGATCTGAACCAA AATCCAGATGGACAGGATATAAGCATGTTTTGTCAAATGGTTTCTTCAGTGGATTTCTTG CCTCCAATGGCTAGTTTAGATAACAAGGGCATGTTATTCACCAGTAATTTTGTTCTAGCC TCCACAAATTCTAACACACTAAGCCCCCCAACAATCTTGAATCCTGAAGCTTTAGTCAGG AGATTTGGTTTTGACCTAGATATATGTTTGCATACTACCTACACAAAGAATGGAAAACTC AATGCAGGCATGTCAACCAAGACATGCAAAGATTGCCATCAACCATCTAATTTCAAGAAA TGTTGCCCCCTAGTCTGTGGAAAAGCTATTAGCTTGGTAGACAGAACTACCAACGTTAGG TATAGTGTGGATCAACTGGTCACGGCTATTATAAGTGATTTCAAGAGCAAAATGCAAATT ACAGATTCCCTAGAAACACTGTTTCAAGGACCAGTGTATAAAGATTTAGAGATTGATGTT TGCAACACACCACCTTCAGAATGTATCAACGATTTACTGAAATCTGTAGATTCAGAAGAG ATTAGGGAATATTGTAAGAAGAAGAAATGGATTATACCTGAAATTCCTACCAACATAGAA AGGGCTATGAATCAAGCCAGCATGATTATTAATACTATTCTGATGTTTGTCAGTACATTA GGTATTGTTTATGTCATTTATAAATTGTTTGCTCAAACTCAAGGACCATATTCTGGTAAC CCGCCTCACAATAAACTAAAAGCCCCAACTTTACGCCCAGTTGTTGTGCAAGGACCAAAC ACAGAATTTGCACTATCCCTGTTAAGGAAAAACATAATGACTATAACAACCTCAAAGGGA GAGTTCACAGGGTTAGGCATACATGATCGTGTCTGTGTGATACCCACACACGCACAGCCT GGTGATGATGTACTAGTGAATGGTCAGAAAATTAGAGTTAAGGATAAGTACAAATTAGTA GATCCAGAGAACATTAATCTAGAGCTTACAGTGTTGACTTTAGATAGAAATGAAAAATTC AGAGATATCAGGGGATTTATATCAGAAGATCTAGAAGGTGTGGATGCCACTTTGGTAGTA CATTCAAATAACTTTACCAACACTATCTTAGAAGTTGGCCCTGTAACAATGGCAGGACTT ATTAATTTGAGTAGCACCCCCACTAACAGAATGATTCGTTATGATTATGCAACAAAAACT GGGCAGTGTGGAGGTGTGCTGTGTGCTACTGGTAAGATCTTTGGTATTCATGTTGGCGGT AATGGAAGACAAGGATTTTCAGCTCAACTTAAAAAACAATATTTTGTAGAGAAACAAGGC CAAGTAATAGCTAGACATAAGGTTAGGGAGTTTAACATAAATCCAGTCAACACGGCAACT AAGTCAAAATTACATCCCAGTGTATTTTATGATGTTTTTCCAGGTGACAAGGAACCTGCT GTATTGAGTGACAATGATCCCAGACTGGAAGTTAAATTGACTGAATCATTATTCTCTAAG TACAAGGGGAATGTAAATACGGAACCCACTGAAAATATGCTTGTGGCTGTAGACCATTAT GCAGGGCAACTATTATCACTAGATATCCCCACTTCTGAACTTACACTAAAAGAAGCATTA TATGGAGTAGATGGACTAGAACCTATAGATATTACAACCAGTGCAGGATTTCCCTATGTG AGTCTTGGGATCAAAAAGAGAGACATTCTGAATAAAGAGACCCAGGACACAGAAAAGATG AAGTTTTATCTAGACAAGTATGGCATTGACTTGCCTCTAGTTACATATATTAAGGATGAA TTAAGAAGTGTTGACAAAGTCCGATTAGGGAAAAGTAGATTAATTGAAGCCTCCAGTTTG AATGATTCTGTTAACATGAGAATGAAACTAGGCAACCTTTACAAAGCATTCCATCAAAAT CCCGGTGTTCTGACTGGATCAGCAGTGGGTTGTGATCCTGATGTGTTTTGGTCTGTCATC CCTTGCTTAATGGATGGGCACCTGATGGCATTTGATTACTCTAATTTTGATGCCTCTTTG TCACCAGTTTGGTTTGTCTGTCTAGAGAAGGTTTTGACCAAGTTAGGCTTTGCAGGCTCT TCATTAATTCAATCAATTTGTAATACCCATCATATCTTTAGGGATGAAATATATGTGGTT GAAGGTGGCATGCCCTCAGGGTGTTCAGGAACCAGCATATTCAATTCCATGATCAACAAC ATAATCATTAGGACTTTGATATTAGATGCATATAAAGGAATAGATTTAGACAAACTTAAA ATCTTAGCTTACGGTGATGATTTGATTGTTTCTTATCCTTATGAACTGGATCCACAAGTG TTGGCAACTCTTGGTAAAAATTATGGACTAACCATCACACCCCCAGACAAATCTGAAACT TTTACAAAAATGACATGGGAAAACTTGACATTTTTAAAGAGATACTTCAAGCCTGATCAA CAATTTCCCTTTTTGGTTCACCCAGTTATGCCCATGAAAGATATACATGAGTCAATCAGA TGGACAAAGGATCCTAAAAACACACAGGATCACGTCCGATCATTATGCATGTTAGCATGG CACTCAGGAGAAAAAGAGTACAATGAATTCATTCAGAAGATCAGAACTACTGACATTGGA AAATGTCTAATTCTCCCAGAATACAGCGTACTTAGGAGGCGCTGGTTGGACCTCTTTTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P03303 UniProtKB Entry Name POLG_HRV14 GenBank Gene ID K02121 PDB ID(s) 1D3I, 1HRI, 1HRV, 1K5M, 1NA1, 1NCQ, 1R08, 1R09, 1RMU, 1RUC, 1RUD, 1RUE, 1RUF, 1RUG, 1RUH, 1RUI, 1RUJ, 1RVF, 1VRH, 1XR5, 2B0F, 2HWB, 2HWC, 2IN2, 2R04, 2R06, 2R07, 2RM2, 2RMU, 2RR1, 2RS1, 2RS3, 2RS5, 4PDW, 4RHV KEGG ID vg:1461213 NCBI Gene ID 1461213 - General References
- Stanway G, Hughes PJ, Mountford RC, Minor PD, Almond JW: The complete nucleotide sequence of a common cold virus: human rhinovirus 14. Nucleic Acids Res. 1984 Oct 25;12(20):7859-75. [Article]
- Lee WM, Monroe SS, Rueckert RR: Role of maturation cleavage in infectivity of picornaviruses: activation of an infectosome. J Virol. 1993 Apr;67(4):2110-22. [Article]
- Callahan PL, Mizutani S, Colonno RJ: Molecular cloning and complete sequence determination of RNA genome of human rhinovirus type 14. Proc Natl Acad Sci U S A. 1985 Feb;82(3):732-6. [Article]
- Gustin KE, Sarnow P: Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus. J Virol. 2002 Sep;76(17):8787-96. [Article]
- Fuchs R, Blaas D: Uncoating of human rhinoviruses. Rev Med Virol. 2010 Sep;20(5):281-97. doi: 10.1002/rmv.654. [Article]
- Fuchs R, Blaas D: Productive entry pathways of human rhinoviruses. Adv Virol. 2012;2012:826301. doi: 10.1155/2012/826301. Epub 2012 Nov 26. [Article]
- Rossmann MG, Arnold E, Erickson JW, Frankenberger EA, Griffith JP, Hecht HJ, Johnson JE, Kamer G, Luo M, Mosser AG, et al.: Structure of a human common cold virus and functional relationship to other picornaviruses. Nature. 1985 Sep 12-18;317(6033):145-53. [Article]
- Arnold E, Rossmann MG: The use of molecular-replacement phases for the refinement of the human rhinovirus 14 structure. Acta Crystallogr A. 1988 May 1;44 ( Pt 3):270-82. [Article]
- Kolatkar PR, Bella J, Olson NH, Bator CM, Baker TS, Rossmann MG: Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor. EMBO J. 1999 Nov 15;18(22):6249-59. [Article]
- Arnold E, Rossmann MG: Analysis of the structure of a common cold virus, human rhinovirus 14, refined at a resolution of 3.0 A. J Mol Biol. 1990 Feb 20;211(4):763-801. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Genome polyprotein (HRV-14) protein primary- Drug Relations