Prostate-specific antigen
Details
- Name
- Prostate-specific antigen
- Synonyms
- 3.4.21.77
- APS
- Gamma-seminoprotein
- Kallikrein-3
- P-30 antigen
- PSA
- Semenogelase
- Seminin
- Gene Name
- KLK3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049681|Prostate-specific antigen MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWV LTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHD LMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVIS NDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERP SLYTKVVHYRKWIKDTIVANP
- Number of residues
- 261
- Molecular Weight
- 28741.1
- Theoretical pI
- Not Available
- GO Classification
- Functionsendopeptidase activity / hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides / serine-type endopeptidase activity / serine-type peptidase activityProcessesantibacterial peptide production / cellular protein metabolic process / negative regulation of angiogenesis / proteolysisComponentsextracellular exosome / extracellular region / extracellular space / nucleus / protein complex
- General Function
- Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
- Specific Function
- Endopeptidase activity
- Pfam Domain Function
- Trypsin (PF00089)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049682|Prostate-specific antigen (KLK3) ATGTGGGTCCCGGTTGTCTTCCTCACCCTGTCCGTGACGTGGATTGGTGCTGCACCCCTC ATCCTGTCTCGGATTGTGGGAGGCTGGGAGTGCGAGAAGCATTCCCAACCCTGGCAGGTG CTTGTGGCCTCTCGTGGCAGGGCAGTCTGCGGCGGTGTTCTGGTGCACCCCCAGTGGGTC CTCACAGCTGCCCACTGCATCAGGAACAAAAGCGTGATCTTGCTGGGTCGGCACAGCCTG TTTCATCCTGAAGACACAGGCCAGGTATTTCAGGTCAGCCACAGCTTCCCACACCCGCTC TACGATATGAGCCTCCTGAAGAATCGATTCCTCAGGCCAGGTGATGACTCCAGCCACGAC CTCATGCTGCTCCGCCTGTCAGAGCCTGCCGAGCTCACGGATGCTGTGAAGGTCATGGAC CTGCCCACCCAGGAGCCAGCACTGGGGACCACCTGCTACGCCTCAGGCTGGGGCAGCATT GAACCAGAGGAGTTCTTGACCCCAAAGAAACTTCAGTGTGTGGACCTCCATGTTATTTCC AATGACGTGTGTGCGCAAGTTCACCCTCAGAAGGTGACCAAGTTCATGCTGTGTGCTGGA CGCTGGACAGGGGGCAAAAGCACCTGCTCGGGTGATTCTGGGGGCCCACTTGTCTGTAAT GGTGTGCTTCAAGGTATCACGTCATGGGGCAGTGAACCATGTGCCCTGCCCGAAAGGCCT TCCCTGTACACCAAGGTGGTGCATTACCGGAAGTGGATCAAGGACACCATCGTGGCCAAC CCCTGA
- Chromosome Location
- 19
- Locus
- 19q13.33
- External Identifiers
Resource Link UniProtKB ID P07288 UniProtKB Entry Name KLK3_HUMAN HGNC ID HGNC:6364 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04839 Cyproterone acetate approved, investigational unknown Details DB00834 Mifepristone approved, investigational unknown Details DB16019 Gallium Ga-68 gozetotide approved yes binder Details DB16778 Lutetium Lu-177 vipivotide tetraxetan approved yes binder Details DB02998 Metribolone experimental unknown activator Details