Cyproterone acetate is a steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer. An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties.
- Mechanism
- Curator reviewed
The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.
- Primary indication
- For the palliative treatment of patients with advanced prostatic carcinoma.Curator reviewed · 13 structured indications
- Formula / weight
- C24H29ClO4 · 416.938 g/mol (avg)
- First approval
- Canada, 1997
- Also known as
- Cyproterone 17-O-acetate
- Code names
- NSC-81430 · SH-714
- Brand names
Resolves to
UWFYSQMTEOIJJG-FDTZYFLXSA-NSMILES[H][C@@]12C[C@]1([H])[C@@]1(C)C(=CC2=O)C(Cl)=C[C@@]2([H])[C@]3([H])CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@]12[H]What you can answer from here — as of June 15, 2026
Which drugs share a target with Cyproterone acetate, and which of those have an active Phase 3 trial?
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