Annexin A4

Details

Name
Annexin A4
Synonyms
  • 35-beta calcimedin
  • Annexin IV
  • Annexin-4
  • ANX4
  • Carbohydrate-binding protein p33/p41
  • Chromobindin-4
  • Endonexin I
  • Lipocortin IV
  • P32.5
  • PAP-II
  • Placental anticoagulant protein II
  • PP4-X
  • Protein II
Gene Name
ANXA4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049654|Annexin A4
MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTI
GRDLIDDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEE
IRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYE
AGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIK
GDTSGDYRKVLLVLCGGDD
Number of residues
319
Molecular Weight
35882.36
Theoretical pI
Not Available
GO Classification
Functions
calcium ion binding / calcium-dependent phospholipid binding / calcium-dependent protein binding / identical protein binding / NF-kappaB binding / phospholipase inhibitor activity
Processes
epithelial cell differentiation / negative regulation of apoptotic process / negative regulation of interleukin-8 secretion / negative regulation of NF-kappaB transcription factor activity / Notch signaling pathway / regulation of transcription from RNA polymerase II promoter / signal transduction
Components
cell surface / cytoplasm / extracellular exosome / nuclear membrane / nucleus / perinuclear region of cytoplasm / plasma membrane / vesicle membrane
General Function
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
Specific Function
Calcium ion binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0049655|Annexin A4 (ANXA4)
ATGGCCATGGCAACCAAAGGAGGTACTGTCAAAGCTGCTTCAGGATTCAATGCCATGGAA
GATGCCCAGACCCTGAGGAAGGCCATGAAAGGGCTCGGCACCGATGAAGACGCCATTATT
AGCGTCCTTGCCTACCGCAACACCGCCCAGCGCCAGGAGATCAGGACAGCCTACAAGAGC
ACCATCGGCAGGGACTTGATAGACGACCTGAAGTCAGAACTGAGTGGCAACTTCGAGCAG
GTGATTGTGGGGATGATGACGCCCACGGTGCTGTATGACGTGCAAGAGCTGCGAAGGGCC
ATGAAGGGAGCCGGCACTGATGAGGGCTGCCTAATTGAGATCCTGGCCTCCCGGACCCCT
GAGGAGATCCGGCGCATAAGCCAAACCTACCAGCAGCAATATGGACGGAGCCTTGAAGAT
GACATTCGCTCTGACACATCGTTCATGTTCCAGCGAGTGCTGGTGTCTCTGTCAGCTGGT
GGGAGGGATGAAGGAAATTATCTGGACGATGCTCTCGTGAGACAGGATGCCCAGGACCTG
TATGAGGCTGGAGAGAAGAAATGGGGGACAGATGAGGTGAAATTTCTAACTGTTCTCTGT
TCCCGGAACCGAAATCACCTGTTGCATGTGTTTGATGAATACAAAAGGATATCACAGAAG
GATATTGAACAGAGTATTAAATCTGAAACATCTGGTAGCTTTGAAGATGCTCTGCTGGCT
ATAGTAAAGTGCATGAGGAACAAATCTGCATATTTTGCTGAAAAGCTCTATAAATCGATG
AAGGGCTTGGGCACCGATGATAACACCCTCATCAGAGTGATGGTTTCTCGAGCAGAAATT
GACATGTTGGATATCCGGGCACACTTCAAGAGACTCTATGGAAAGTCTCTGTACTCGTTC
ATCAAGGGTGACACATCTGGAGACTACAGGAAAGTACTGCTTGTTCTCTGTGGAGGAGAT
GATTAA
Chromosome Location
2
Locus
2p13.3
External Identifiers
ResourceLink
UniProtKB IDP09525
UniProtKB Entry NameANXA4_HUMAN
HGNC IDHGNC:542
General References
  1. Grundmann U, Amann E, Abel KJ, Kupper HA: Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. Behring Inst Mitt. 1988 Apr;(82):59-67. [Article]
  2. Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM: Chromosomal mapping of the human annexin IV (ANX4) gene. Genomics. 1992 Feb;12(2):313-8. [Article]
  3. Satoh A, Takayama E, Kojima K, Ogawa H, Katsura Y, Kina T, Matsumoto I: Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. Biol Pharm Bull. 1997 Mar;20(3):224-9. [Article]
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  7. Tait JF, Sakata M, McMullen BA, Miao CH, Funakoshi T, Hendrickson LE, Fujikawa K: Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. Biochemistry. 1988 Aug 23;27(17):6268-76. [Article]
  8. Ahn NG, Teller DC, Bienkowski MJ, McMullen BA, Lipkin EW, de Haen C: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor. J Biol Chem. 1988 Dec 15;263(35):18657-63. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails
DB00591Fluocinolone acetonideapproved, investigational, vet_approvedyesinducerDetails