Uridine phosphorylase

Details

Name
Uridine phosphorylase
Synonyms
  • 2.4.2.3
  • UPase
Gene Name
udp
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Amino acid sequence
>lcl|BSEQ0012100|Uridine phosphorylase
MSKSDVFHLGLTKNDLQGAQLAIVPGDPERVEKIAALMDKPVKLASHREFTSWRAELDGK
AVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGAS
LHFAPMEFPAVADFACTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRRF
KGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESH
AVKIVVEAARRLL
Number of residues
253
Molecular Weight
27138.91
Theoretical pI
6.51
GO Classification
Functions
uridine phosphorylase activity
Processes
nucleotide catabolic process / UMP salvage
Components
cytoplasm
General Function
Uridine phosphorylase activity
Specific Function
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012101|Uridine phosphorylase (udp)
ATGTCCAAGTCTGATGTTTTTCATCTCGGCCTCACCAAAAACGATTTACAAGGGGCCCAG
CTCGCCATCGTCCCTGGCGATCCTGAGCGTGTGGAAAAGATCGCCGCGCTGATGGATAAG
CCGGTTAAGCTGGCATCTCACCGCGAATTCACCTCCTGGCGCGCTGAGCTGGATGGCAAA
GCAGTTATCGTTTGCTCTACCGGTATCGGTGGCCCGTCTACCTCTATTGCCGTGGAAGAA
CTGGCGCAACTGGGTATTCGTACCTTCTTGCGTATCGGCACCACGGGGGCTATTCAGCCG
CACATTAACGTCGGCGACGTTCTGGTAACGACCGCATCCGTACGTCTGGATGGGGCGAGC
CTGCATTTTGCGCCGATGGAATTCCCGGCGGTTGCCGACTTTGCCTGCACCACTGCGCTG
GTTGAAGCCGCGAAATCGATTGGCGCCACGACTCACGTTGGCGTAACCGCCTCTTCCGAC
ACTTTCTATCCGGGTCAGGAACGTTACGACACCTATTCTGGCCGCGTTGTTCGTCGCTTC
AAAGGCTCTATGGAAGAGTGGCAGGCGATGGGCGTGATGAACTACGAAATGGAATCCGCT
ACGCTGTTAACCATGTGCGCAAGCCAGGGTTTACGCGCAGGTATGGTGGCGGGCGTTATC
GTCAACCGTACCCAACAAGAGATTCCGAATGCGGAAACGATGAAACAAACTGAAAGCCAC
GCGGTGAAAATCGTCGTGGAAGCGGCCCGTCGTCTGCTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A1F6
UniProtKB Entry NameUDP_SALTY
GenBank Gene IDY14282
General References
  1. Veiko VP, Chebotaev DV, Ovcharova IV, Gul'ko LB: [Protein engineering of uridine phosphorylase from Escherichia coli K-12. I. Cloning and expression of uridine phosphorylase genes from Klebsiella aerogenes and Salmonella typhimurium in E. coli]. Bioorg Khim. 1998 May;24(5):381-7. [Article]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04627CyclouridineexperimentalunknownDetails