Uridine phosphorylase

Details

Name

Uridine phosphorylase

Synonyms

• 2.4.2.3
• UPase

Gene Name

udp

UniProtKB Entry

P0A1F6Swiss-Prot

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

NCBI Taxonomy ID

99287

Amino acid sequence

>lcl|BSEQ0012100|Uridine phosphorylase
MSKSDVFHLGLTKNDLQGAQLAIVPGDPERVEKIAALMDKPVKLASHREFTSWRAELDGK
AVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGAS
LHFAPMEFPAVADFACTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRRF
KGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESH
AVKIVVEAARRLL

Number of residues

253

Molecular Weight

27138.91

Theoretical pI

6.51

GO Classification

Functions

uridine phosphorylase activity

Processes

nucleotide catabolic process / UMP salvage

Components

cytoplasm

General Function

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.

Specific Function

uridine phosphorylase activity

Pfam Domain Function

• PNP_UDP_1 (PF01048)

Signal Regions

Not Available

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0012101|Uridine phosphorylase (udp)
ATGTCCAAGTCTGATGTTTTTCATCTCGGCCTCACCAAAAACGATTTACAAGGGGCCCAG
CTCGCCATCGTCCCTGGCGATCCTGAGCGTGTGGAAAAGATCGCCGCGCTGATGGATAAG
CCGGTTAAGCTGGCATCTCACCGCGAATTCACCTCCTGGCGCGCTGAGCTGGATGGCAAA
GCAGTTATCGTTTGCTCTACCGGTATCGGTGGCCCGTCTACCTCTATTGCCGTGGAAGAA
CTGGCGCAACTGGGTATTCGTACCTTCTTGCGTATCGGCACCACGGGGGCTATTCAGCCG
CACATTAACGTCGGCGACGTTCTGGTAACGACCGCATCCGTACGTCTGGATGGGGCGAGC
CTGCATTTTGCGCCGATGGAATTCCCGGCGGTTGCCGACTTTGCCTGCACCACTGCGCTG
GTTGAAGCCGCGAAATCGATTGGCGCCACGACTCACGTTGGCGTAACCGCCTCTTCCGAC
ACTTTCTATCCGGGTCAGGAACGTTACGACACCTATTCTGGCCGCGTTGTTCGTCGCTTC
AAAGGCTCTATGGAAGAGTGGCAGGCGATGGGCGTGATGAACTACGAAATGGAATCCGCT
ACGCTGTTAACCATGTGCGCAAGCCAGGGTTTACGCGCAGGTATGGTGGCGGGCGTTATC
GTCAACCGTACCCAACAAGAGATTCCGAATGCGGAAACGATGAAACAAACTGAAAGCCAC
GCGGTGAAAATCGTCGTGGAAGCGGCCCGTCGTCTGCTGTAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P0A1F6
UniProtKB Entry Name	UDP_SALTY
GenBank Gene ID	Y14282
PDB ID(s)	1RYZ, 1SJ9, 1Y1Q, 1Y1R, 1Y1S, 1Y1T, 1ZL2, 2HN9, 2HRD, 2HSW, 2HWU, 2I8A, 2IQ5, 2OEC, 2OXF, 2PGA, 2QDK, 2RJ3, 3C74, 3DDO, 3DPS, 3FWP, 4E1V, 4OGK
KEGG ID	stm:STM3968
NCBI Gene ID	1255494

General References

1. Veiko VP, Chebotaev DV, Ovcharova IV, Gul'ko LB: [Protein engineering of uridine phosphorylase from Escherichia coli K-12. I. Cloning and expression of uridine phosphorylase genes from Klebsiella aerogenes and Salmonella typhimurium in E. coli]. Bioorg Khim. 1998 May;24(5):381-7. [Article]
2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]

Associated Data

Bio-Entities

Bio-Entity	Type
Uridine phosphorylase (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720))	protein primary

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Cyclouridine	experimental	unknown	target		Details