Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
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McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
Nature. 2001 Oct 25;413(6858):852-6.
- PubMed ID
- 11677609 [ View in PubMed]
- Abstract
Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause of human gastroenteritis, and is used as a mouse model of human typhoid fever. The incidence of non-typhoid salmonellosis is increasing worldwide, causing millions of infections and many deaths in the human population each year. Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of close homologues of S. typhimurium LT2 genes in eight related enterobacteria was determined using previously completed genomes of three related bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S. typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29% missing from Escherichia coli K12. The 352 gene homologues of S. typhimurium LT2 confined to subspecies I of S. enterica-containing most mammalian and bird pathogens-are useful for studies of epidemiology, host specificity and pathogenesis. Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 Details Nitrogen regulation protein NR(I) P41789 Details Nicotinate-nucleotide pyrophosphorylase [carboxylating] P30012 Details Methyl-accepting chemotaxis protein II P02941 Details Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase P55882 Details UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase Q8ZNF3 Details Orotate phosphoribosyltransferase P08870 Details Sialidase P29768 Details Threonine-phosphate decarboxylase P97084 Details dTDP-4-dehydrorhamnose 3,5-epimerase P26394 Details CDP-glucose 4,6-dehydratase P26397 Details dTDP-glucose 4,6-dehydratase P26391 Details Ribonucleoside-diphosphate reductase 2 subunit alpha Q08698 Details Glutamine synthetase P0A1P6 Details Glucose-1-phosphate thymidylyltransferase P26393 Details Acetyl-coenzyme A synthetase Q8ZKF6 Details Acyl carrier protein P0A6B1 Details dTDP-4-dehydrorhamnose reductase P26392 Details Siroheme synthase P25924 Details Chemotaxis protein methyltransferase P07801 Details Bifunctional adenosylcobalamin biosynthesis protein CobU Q05599 Details Glucose-1-phosphate cytidylyltransferase P26396 Details Alkyl hydroperoxide reductase subunit F P19480 Details Uridine phosphorylase P0A1F6 Details FMN-dependent NADH-azoreductase P63462 Details D-galactose-binding periplasmic protein P23905 Details Maltoporin P26466 Details Periplasmic oligopeptide-binding protein P06202 Details Tryptophan synthase alpha chain P00929 Details Tryptophan synthase beta chain P0A2K1 Details Virulence sensor histidine kinase PhoQ P0DM80 Details