Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.

Article Details


McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK

Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.

Nature. 2001 Oct 25;413(6858):852-6.

PubMed ID
11677609 [ View in PubMed

Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause of human gastroenteritis, and is used as a mouse model of human typhoid fever. The incidence of non-typhoid salmonellosis is increasing worldwide, causing millions of infections and many deaths in the human population each year. Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of close homologues of S. typhimurium LT2 genes in eight related enterobacteria was determined using previously completed genomes of three related bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S. typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29% missing from Escherichia coli K12. The 352 gene homologues of S. typhimurium LT2 confined to subspecies I of S. enterica-containing most mammalian and bird pathogens-are useful for studies of epidemiology, host specificity and pathogenesis. Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets.

DrugBank Data that Cites this Article

NameUniProt ID
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseQ05603Details
Nitrogen regulation protein NR(I)P41789Details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]P30012Details
Methyl-accepting chemotaxis protein IIP02941Details
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinaseP55882Details
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferaseQ8ZNF3Details
Orotate phosphoribosyltransferaseP08870Details
Threonine-phosphate decarboxylaseP97084Details
dTDP-4-dehydrorhamnose 3,5-epimeraseP26394Details
CDP-glucose 4,6-dehydrataseP26397Details
dTDP-glucose 4,6-dehydrataseP26391Details
Ribonucleoside-diphosphate reductase 2 subunit alphaQ08698Details
Glutamine synthetaseP0A1P6Details
Glucose-1-phosphate thymidylyltransferaseP26393Details
Acetyl-coenzyme A synthetaseQ8ZKF6Details
Acyl carrier proteinP0A6B1Details
dTDP-4-dehydrorhamnose reductaseP26392Details
Siroheme synthaseP25924Details
Chemotaxis protein methyltransferaseP07801Details
Bifunctional adenosylcobalamin biosynthesis protein CobUQ05599Details
Glucose-1-phosphate cytidylyltransferaseP26396Details
Alkyl hydroperoxide reductase subunit FP19480Details
Uridine phosphorylaseP0A1F6Details
FMN-dependent NADH-azoreductaseP63462Details
D-galactose-binding periplasmic proteinP23905Details
Periplasmic oligopeptide-binding proteinP06202Details
Tryptophan synthase alpha chainP00929Details
Tryptophan synthase beta chainP0A2K1Details
Virulence sensor histidine kinase PhoQP0DM80Details