Thymidine kinase
Details
- Name
- Thymidine kinase
- Synonyms
- 2.7.1.21
- Gene Name
- Not Available
- Organism
- HHV-3
- Amino acid sequence
>lcl|BSEQ0012353|Thymidine kinase MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCLRSMSPFVLSLEQ TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
- Number of residues
- 341
- Molecular Weight
- 37842.57
- Theoretical pI
- 7.22
- GO Classification
- FunctionsATP binding / thymidine kinase activityProcessesDNA biosynthetic process / TMP biosynthetic process
- General Function
- Thymidine kinase activity
- Specific Function
- In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.
- Pfam Domain Function
- Herpes_TK (PF00693)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006565|1026 bp ATGTCAACGGATAAAACCGATGTAAAAATGGGCGTTTTGCGTATTTATTTGGACGGGGCG TATGGAATTGGAAAAACAACCGCCGCCGAAGAATTTTTACACCACTTTGCAATAACACCA AACCGGATCTTACTCATTGGGGAGCCCCTGTCGTATTGGCGTAACCTTGCAGGGGAGGAC GCTATTTGCGGAATTTACGGAACACAAACTCGCCGTCTTAATGGAGACGTTTCGCCTGAA GACGCACAACGCCTCACGGCTCATTTTCAGAGCCTGTTCTGTTCTCCGCATGCAATTATG CATGCGAAAATCTCGGCATTGATGGACACAAGTACATCGGATCTCGTACAAGTAAATAAG GAGCCGTATAAAATTATGTTATCCGACCGACACCCAATCGCCTCAACTATATGTTTTCCC TTGTCCAGATACTTAGTGGGAGATATGTCCCCAGCGGCGCTTCCTGGGTTATTGTTTACG CTTCCCGCTGAACCCCCCGGGACCAACTTGGTAGTTTGTACCGTTTCACTCCCCAGTCAT TTATCCAGAGTAAGCAAACGGGCCAGACCGGGAGAAACGGTTAATCTGCCGTTTGTTATG GTTCTGAGAAATGTATATATAATGCTTATTAATACAATTATATTTCTTAAAACTAACAAC TGGCACGCGGGCTGGAACACACTGTCATTTTGTAATGATGTATTTAAACAGAAATTACAA AAATCCGAGTGTATAAAACTACGCGAAGTACCTGGGATTGAAGACACGTTATTCGCCGTN CTTAAACTTCCGGAGCTTTGCGGAGAGTTTGGAAATATTCTGCCGTTATGGGCATGGGGA ATGGAGACCCTTTCAAACTGCTTACGAAGCATGTCTCCGTTCGTATTATCGTTAGAACAG ACACCCCAGCATGCGGCACAAGAACTAAAAACTCTGCTACCCCAGATGACCCCGGCAAAC ATGTCCTCCGGTGCATGGAATATATTGAAAGAGCTTGTTAATGCCGTTCAGGACAACACT TCCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0C0E6 UniProtKB Entry Name KITH_VZVO GenBank Gene ID M36160 - General References
- Sawyer MH, Inchauspe G, Biron KK, Waters DJ, Straus SE, Ostrove JM: Molecular analysis of the pyrimidine deoxyribonucleoside kinase gene of wild-type and acyclovir-resistant strains of varicella-zoster virus. J Gen Virol. 1988 Oct;69 ( Pt 10):2585-93. [Article]
- Mori H, Shiraki K, Kato T, Hayakawa Y, Yamanishi K, Takahashi M: Molecular analysis of the thymidine kinase gene of thymidine kinase-deficient mutants of varicella-zoster virus. Intervirology. 1988;29(6):301-10. [Article]
- Lacey SF, Suzutani T, Powell KL, Purifoy DJ, Honess RW: Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction. J Gen Virol. 1991 Mar;72 ( Pt 3):623-30. [Article]
- Gomi Y, Sunamachi H, Mori Y, Nagaike K, Takahashi M, Yamanishi K: Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus. J Virol. 2002 Nov;76(22):11447-59. [Article]
- Tillieux SL, Halsey WS, Thomas ES, Voycik JJ, Sathe GM, Vassilev V: Complete DNA sequences of two oka strain varicella-zoster virus genomes. J Virol. 2008 Nov;82(22):11023-44. doi: 10.1128/JVI.00777-08. Epub 2008 Sep 10. [Article]
- Bird LE, Ren J, Wright A, Leslie KD, Degreve B, Balzarini J, Stammers DK: Crystal structure of varicella zoster virus thymidine kinase. J Biol Chem. 2003 Jul 4;278(27):24680-7. Epub 2003 Apr 9. [Article]