Aminopyrimidine aminohydrolase

Details

Name
Aminopyrimidine aminohydrolase
Synonyms
  • 3.5.99.2
  • 4-amino-5-aminomethyl-2-methylpyrimidine hydrolase
  • Thiaminase II
Gene Name
tenA
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0019139|Aminopyrimidine aminohydrolase
MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQDSYYLTHFAKVQSFGAA
YAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKAFKPSPTAYSYTSHMYRSV
LSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWIGTYGGDWFRQQVEEQINRFD
ELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGWSDSAIKEVEECGASRHNG
Number of residues
236
Molecular Weight
27416.405
Theoretical pI
4.93
GO Classification
Functions
thiaminase activity
Processes
thiamine biosynthetic process / thiamine diphosphate biosynthetic process
General Function
Thiaminase activity
Specific Function
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP). To a lesser extent, is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity is unlikely to be physiologically relevant. Therefore, is involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0019140|Aminopyrimidine aminohydrolase (tenA)
GTGAAGTTTTCAGAAGAATGCCGCAGTGCAGCCGCAGAATGGTGGGAGGGGAGCTTTGTC
CATCCGTTCGTTCAAGGAATCGGTGACGGAACGCTTCCGATTGACCGTTTTAAATACTAC
GTACTTCAGGATTCCTATTATTTAACGCATTTTGCAAAGGTGCAGTCATTTGGTGCCGCT
TATGCGAAGGATCTTTATACAACGGGGCGGATGGCAAGCCATGCCCAAGGTACATATGAG
GCGGAAATGGCGCTTCATCGCGAGTTTGCCGAGCTGTTGGAAATCAGCGAGGAAGAGCGT
AAGGCGTTTAAGCCGTCTCCTACGGCGTACTCTTATACATCCCATATGTACCGTTCGGTT
TTGAGCGGGAATTTCGCAGAAATCTTAGCGGCCCTGCTGCCATGCTATTGGCTCTATTAC
GAGGTTGGTGAGAAATTGCTGCATTGTGATCCGGGGCATCCAATTTATCAGAAGTGGATT
GGCACATATGGCGGTGATTGGTTTAGACAACAGGTCGAGGAGCAAATCAACCGCTTTGAT
GAGCTGGCGGAAAACAGCACGGAGGAAGTGCGTGCCAAGATGAAAGAGAATTTTGTCATC
TCCAGCTACTATGAATATCAATTTTGGGGAATGGCCTATCGAAAAGAAGGCTGGTCTGAC
AGCGCCATAAAAGAGGTGGAGGAATGTGGAGCTTCACGCCATAACGGATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP25052
UniProtKB Entry NameTENA_BACSU
GenBank Protein ID143729
GenBank Gene IDM73546
General References
  1. Pang AS, Nathoo S, Wong SL: Cloning and characterization of a pair of novel genes that regulate production of extracellular enzymes in Bacillus subtilis. J Bacteriol. 1991 Jan;173(1):46-54. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Lee JM, Zhang S, Saha S, Santa Anna S, Jiang C, Perkins J: RNA expression analysis using an antisense Bacillus subtilis genome array. J Bacteriol. 2001 Dec;183(24):7371-80. [Article]
  4. Jenkins AH, Schyns G, Potot S, Sun G, Begley TP: A new thiamin salvage pathway. Nat Chem Biol. 2007 Aug;3(8):492-7. Epub 2007 Jul 8. [Article]
  5. Toms AV, Haas AL, Park JH, Begley TP, Ealick SE: Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. [Article]
  6. Jenkins AL, Zhang Y, Ealick SE, Begley TP: Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorg Chem. 2008 Feb;36(1):29-32. Epub 2007 Dec 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB020224-Amino-5-Hydroxymethyl-2-MethylpyrimidineexperimentalunknownDetails