dTDP-4-dehydrorhamnose 3,5-epimerase
Details
- Name
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Synonyms
- 5.1.3.13
- dTDP-4-keto-6-deoxyglucose 3,5-epimerase
- dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
- dTDP-L-rhamnose synthase
- rmlC
- Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
- Gene Name
- rfbC
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Amino acid sequence
>lcl|BSEQ0016517|dTDP-4-dehydrorhamnose 3,5-epimerase MMIVIKTAIPDVLILEPKVFGDERGFFFESYNQQTFEELIGRKVTFVQDNHSKSKKNVLR GLHFQRGENAQGKLVRCAVGEVFDVAVDIRKESPTFGQWVGVNLSAENKRQLWIPEGFAH GFVTLSEYAEFLYKATNYYSPSSEGSILWNDEAIGIEWPFSQLPELSAKDAAAPLLDQAL LTE
- Number of residues
- 183
- Molecular Weight
- 20663.29
- Theoretical pI
- 4.76
- GO Classification
- FunctionsdTDP-4-dehydrorhamnose 3,5-epimerase activityProcessesdTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process / O antigen biosynthetic process
- General Function
- Dtdp-4-dehydrorhamnose 3,5-epimerase activity
- Specific Function
- Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
- Pfam Domain Function
- dTDP_sugar_isom (PF00908)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016518|dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC) GTGATGATTGTGATTAAAACAGCAATACCAGATGTCTTGATCTTAGAGCCTAAAGTTTTT GGCGATGAGAGGGGATTCTTTTTTGAAAGTTATAACCAGCAGACCTTTGAAGAGTTGATT GGACGTAAAGTTACATTTGTTCAAGATAATCATTCAAAATCCAAAAAGAACGTACTCAGA GGGCTACATTTTCAGAGAGGAGAAAATGCACAGGGGAAGTTAGTTCGTTGTGCTGTCGGT GAGGTTTTTGATGTTGCGGTCGATATCCGAAAAGAATCGCCTACTTTTGGTCAATGGGTT GGTGTAAATCTGTCTGCTGAGAATAAGCGACAGCTTTGGATTCCAGAAGGTTTTGCTCAT GGTTTTGTTACTCTTAGTGAGTATGCAGAGTTTCTGTACAAAGCAACTAATTATTACTCA CCTTCATCGGAAGGTAGCATTCTATGGAATGATGAGGCAATAGGTATTGAATGGCCTTTT TCTCAGCTGCCTGAGCTTTCAGCAAAAGATGCTGCAGCACCTTTACTGGATCAAGCCTTG TTAACAGAGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26394 UniProtKB Entry Name RMLC_SALTY GenBank Protein ID 581655 GenBank Gene ID X56793 - General References
- Jiang XM, Neal B, Santiago F, Lee SJ, Romana LK, Reeves PR: Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2). Mol Microbiol. 1991 Mar;5(3):695-713. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH: RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol. 2007 Jan 5;365(1):146-59. Epub 2006 Sep 29. [Article]
- Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH: RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat Struct Biol. 2000 May;7(5):398-402. [Article]