dTDP-4-dehydrorhamnose 3,5-epimerase

Details

Name
dTDP-4-dehydrorhamnose 3,5-epimerase
Synonyms
  • 5.1.3.13
  • dTDP-4-keto-6-deoxyglucose 3,5-epimerase
  • dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
  • dTDP-L-rhamnose synthase
  • rmlC
  • Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
Gene Name
rfbC
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Amino acid sequence
>lcl|BSEQ0016517|dTDP-4-dehydrorhamnose 3,5-epimerase
MMIVIKTAIPDVLILEPKVFGDERGFFFESYNQQTFEELIGRKVTFVQDNHSKSKKNVLR
GLHFQRGENAQGKLVRCAVGEVFDVAVDIRKESPTFGQWVGVNLSAENKRQLWIPEGFAH
GFVTLSEYAEFLYKATNYYSPSSEGSILWNDEAIGIEWPFSQLPELSAKDAAAPLLDQAL
LTE
Number of residues
183
Molecular Weight
20663.29
Theoretical pI
4.76
GO Classification
Functions
dTDP-4-dehydrorhamnose 3,5-epimerase activity
Processes
dTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process / O antigen biosynthetic process
General Function
Dtdp-4-dehydrorhamnose 3,5-epimerase activity
Specific Function
Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016518|dTDP-4-dehydrorhamnose 3,5-epimerase (rfbC)
GTGATGATTGTGATTAAAACAGCAATACCAGATGTCTTGATCTTAGAGCCTAAAGTTTTT
GGCGATGAGAGGGGATTCTTTTTTGAAAGTTATAACCAGCAGACCTTTGAAGAGTTGATT
GGACGTAAAGTTACATTTGTTCAAGATAATCATTCAAAATCCAAAAAGAACGTACTCAGA
GGGCTACATTTTCAGAGAGGAGAAAATGCACAGGGGAAGTTAGTTCGTTGTGCTGTCGGT
GAGGTTTTTGATGTTGCGGTCGATATCCGAAAAGAATCGCCTACTTTTGGTCAATGGGTT
GGTGTAAATCTGTCTGCTGAGAATAAGCGACAGCTTTGGATTCCAGAAGGTTTTGCTCAT
GGTTTTGTTACTCTTAGTGAGTATGCAGAGTTTCTGTACAAAGCAACTAATTATTACTCA
CCTTCATCGGAAGGTAGCATTCTATGGAATGATGAGGCAATAGGTATTGAATGGCCTTTT
TCTCAGCTGCCTGAGCTTTCAGCAAAAGATGCTGCAGCACCTTTACTGGATCAAGCCTTG
TTAACAGAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP26394
UniProtKB Entry NameRMLC_SALTY
GenBank Protein ID581655
GenBank Gene IDX56793
General References
  1. Jiang XM, Neal B, Santiago F, Lee SJ, Romana LK, Reeves PR: Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2). Mol Microbiol. 1991 Mar;5(3):695-713. [Article]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
  3. Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH: RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol. 2007 Jan 5;365(1):146-59. Epub 2006 Sep 29. [Article]
  4. Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH: RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat Struct Biol. 2000 May;7(5):398-402. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB025493'-O-Acetylthymidine-5'-diphosphateexperimentalunknownDetails