Ribonuclease 4

Details

Name
Ribonuclease 4
Synonyms
  • 3.1.27.-
  • RNase 4
  • RNS4
Gene Name
RNASE4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0016614|Ribonuclease 4
MALQRTHSLLLLLLLTLLGLGLVQPSYGQDGMYQRFLRQHVHPEETGGSDRYCNLMMQRR
KMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNC
RYRAIASTRRVVIACEGNPQVPVHFDG
Number of residues
147
Molecular Weight
16840.37
Theoretical pI
9.17
GO Classification
Functions
endonuclease activity / nucleic acid binding / ribonuclease A activity / ribonuclease activity
Processes
mRNA cleavage / RNA phosphodiester bond hydrolysis, endonucleolytic
Components
extracellular exosome / extracellular region
General Function
Ribonuclease activity
Specific Function
This RNase has marked specificity towards the 3' side of uridine nucleotides.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0016615|Ribonuclease 4 (RNASE4)
ATGGCTCTGCAGAGGACCCATTCATTGCTTCTGCTTTTGCTGCTGACCCTGCTGGGGCTG
GGGCTGGTCCAGCCCTCCTATGGCCAGGATGGCATGTACCAGCGATTCCTGCGGCAACAC
GTGCACCCTGAGGAGACAGGTGGCAGTGATCGCTACTGCAACTTGATGATGCAAAGACGG
AAGATGACTTTGTATCACTGCAAGCGCTTCAACACCTTCATCCATGAAGATATCTGGAAC
ATTCGTAGTATCTGCAGCACCACCAATATCCAATGCAAGAACGGCAAGATGAACTGCCAT
GAGGGTGTAGTGAAGGTCACAGATTGCAGGGACACAGGAAGTTCCAGGGCACCCAACTGC
AGATATCGGGCCATAGCGAGCACTAGACGTGTTGTCATTGCCTGTGAGGGTAACCCACAG
GTGCCTGTGCACTTTGACGGTTAG
Chromosome Location
14
Locus
14q11.1
External Identifiers
ResourceLink
UniProtKB IDP34096
UniProtKB Entry NameRNAS4_HUMAN
GenBank Protein ID976229
GenBank Gene IDD37931
GenAtlas IDRNASE4
HGNC IDHGNC:10047
General References
  1. Seno M, Futami J, Tsushima Y, Akutagawa K, Kosaka M, Tada H, Yamada H: Molecular cloning and expression of human ribonuclease 4 cDNA. Biochim Biophys Acta. 1995 Apr 26;1261(3):424-6. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Rosenberg HF, Dyer KD: Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. Nucleic Acids Res. 1995 Nov 11;23(21):4290-5. [Article]
  4. Zhou HM, Strydom DJ: The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. Eur J Biochem. 1993 Oct 1;217(1):401-10. [Article]
  5. Shapiro R, Fett JW, Strydom DJ, Vallee BL: Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. Biochemistry. 1986 Nov 18;25(23):7255-64. [Article]
  6. Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Ruth FX, Coll M: The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J Mol Biol. 1999 Jan 8;285(1):205-14. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB034482'-Deoxyuridine 3'-MonophosphateexperimentalunknownDetails