Ribonuclease 4
Details
- Name
- Ribonuclease 4
- Synonyms
- 3.1.27.-
- RNase 4
- RNS4
- Gene Name
- RNASE4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016614|Ribonuclease 4 MALQRTHSLLLLLLLTLLGLGLVQPSYGQDGMYQRFLRQHVHPEETGGSDRYCNLMMQRR KMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNC RYRAIASTRRVVIACEGNPQVPVHFDG
- Number of residues
- 147
- Molecular Weight
- 16840.37
- Theoretical pI
- 9.17
- GO Classification
- Functionsendonuclease activity / nucleic acid binding / ribonuclease A activity / ribonuclease activityProcessesmRNA cleavage / RNA phosphodiester bond hydrolysis, endonucleolyticComponentsextracellular exosome / extracellular region
- General Function
- Ribonuclease activity
- Specific Function
- This RNase has marked specificity towards the 3' side of uridine nucleotides.
- Pfam Domain Function
- RnaseA (PF00074)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016615|Ribonuclease 4 (RNASE4) ATGGCTCTGCAGAGGACCCATTCATTGCTTCTGCTTTTGCTGCTGACCCTGCTGGGGCTG GGGCTGGTCCAGCCCTCCTATGGCCAGGATGGCATGTACCAGCGATTCCTGCGGCAACAC GTGCACCCTGAGGAGACAGGTGGCAGTGATCGCTACTGCAACTTGATGATGCAAAGACGG AAGATGACTTTGTATCACTGCAAGCGCTTCAACACCTTCATCCATGAAGATATCTGGAAC ATTCGTAGTATCTGCAGCACCACCAATATCCAATGCAAGAACGGCAAGATGAACTGCCAT GAGGGTGTAGTGAAGGTCACAGATTGCAGGGACACAGGAAGTTCCAGGGCACCCAACTGC AGATATCGGGCCATAGCGAGCACTAGACGTGTTGTCATTGCCTGTGAGGGTAACCCACAG GTGCCTGTGCACTTTGACGGTTAG
- Chromosome Location
- 14
- Locus
- 14q11.1
- External Identifiers
Resource Link UniProtKB ID P34096 UniProtKB Entry Name RNAS4_HUMAN GenBank Protein ID 976229 GenBank Gene ID D37931 GenAtlas ID RNASE4 HGNC ID HGNC:10047 - General References
- Seno M, Futami J, Tsushima Y, Akutagawa K, Kosaka M, Tada H, Yamada H: Molecular cloning and expression of human ribonuclease 4 cDNA. Biochim Biophys Acta. 1995 Apr 26;1261(3):424-6. [Article]
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- Rosenberg HF, Dyer KD: Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. Nucleic Acids Res. 1995 Nov 11;23(21):4290-5. [Article]
- Zhou HM, Strydom DJ: The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. Eur J Biochem. 1993 Oct 1;217(1):401-10. [Article]
- Shapiro R, Fett JW, Strydom DJ, Vallee BL: Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. Biochemistry. 1986 Nov 18;25(23):7255-64. [Article]
- Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Ruth FX, Coll M: The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J Mol Biol. 1999 Jan 8;285(1):205-14. [Article]