Corticotropin-releasing factor receptor 1
Details
- Name
- Corticotropin-releasing factor receptor 1
- Synonyms
- Corticotropin-releasing hormone receptor 1
- CRF-R-1
- CRFR
- CRFR1
- CRH-R-1
- CRH-R1
- CRHR
- Gene Name
- CRHR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0050159|Corticotropin-releasing factor receptor 1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV ARAMSIPTSPTRVSFHSIKQSTAV
- Number of residues
- 444
- Molecular Weight
- 50718.755
- Theoretical pI
- Not Available
- GO Classification
- Functionscorticotrophin-releasing factor receptor activityProcessesactivation of adenylate cyclase activity / cell surface receptor signaling pathway / cellular response to corticotropin-releasing hormone stimulus / corticotropin secretion / female pregnancy / immune response / negative regulation of voltage-gated calcium channel activity / parturition / positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway / regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway / regulation of corticosterone secretionComponentsendosome / integral component of membrane / integral component of plasma membrane / intrinsic component of plasma membrane / plasma membrane
- General Function
- G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
- Specific Function
- Corticotrophin-releasing factor receptor activity
- Pfam Domain Function
- Transmembrane Regions
- 112-142 179-203 219-247 255-282 299-324 336-360 368-397
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0050160|Corticotropin-releasing factor receptor 1 (CRHR1) ATGGTGTCCGCTACAATACCACAAAAAAAAAGCAAGGTGCACTACCATGTCGCAGTCATC ATCAACTACCTGGGCCACTGTATCTCCCTGGTGGCCCTCCTGGTGGCCTTTGTCCTCTTT CTGCGGCTCAGGAGCATCCGGTGCCTGCGAAACATCATCCACTGGAACCTCATCTCCGCC TTCATCCTGCGCAACGCCACCTGGTTCGTGGTCCAGCTAACCATGAGCCCCGAGGTCCAC CAGAGCAACGTGGGCTGGTGCAGGTTGGTGACAGCCGCCTACAACTACTTCCATGTGACC AACTTCTTCTGGATGTTCGGCGAGGGCTGCTACCTGCACACAGCCATCGTGCTCACCTAC TCCACTGACCGGCTGCGCAAATGGATGTTCATCTGCATTGGCTGGGGTGTGCCCTTCCCC ATCATTGTGGCCTGGGCCATTGGGAAGCTGTACTACGACAATGAGAAGTGCTGGTTTGGC AAAAGGCCTGGGGTGTACACCGACTACATCTACCAGGGCCCCATGATCCTGGTCCTGCTG ATCAATTTCATCTTCCTTTTCAACATCGTCCGCATCCTCATGACCAAGCTCCGGGCATCC ACCACGTCTGAGACCATTCAGTACAGGGCTTCTTTGTGTCTGTGTTCTACTGTTTCCTCA ATAGTGAGGTCCGTTCTGCCATCCGGAAGAGGTGGCACCGGTGGCAGGACAAGCACTCGA TCCGTGCCCGAGTGGCCCGTGCCATGTCCATCCCCACCTCCCCAACCCGTGTCAGCTTTC ACAGCATCAAGCAGTCCACAGCAGTCTGAGCTGGCAGGTCATGGAGCAGCCCCCAAAGAG CTGTGGCTGGGGGGATGA
- Chromosome Location
- 17
- Locus
- 17q21.31
- External Identifiers
Resource Link UniProtKB ID P34998 UniProtKB Entry Name CRFR1_HUMAN HGNC ID HGNC:2357 - General References
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