Manganese-dependent inorganic pyrophosphatase

Details

Name
Manganese-dependent inorganic pyrophosphatase
Synonyms
  • 3.6.1.1
  • PPase
  • Pyrophosphate phospho-hydrolase
Gene Name
ppaC
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0011974|Manganese-dependent inorganic pyrophosphatase
MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNGETQYALDYFKQESPRL
VETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIANFETAEPLYYRAEPVGCTA
TILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTDQDVAAAKELAEIAGVDAEEY
GLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQVNTVDIEDVKKRQAELEAVISK
VVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEKAFNVTLENNTALLKGVVSRKKQVV
PVLTDAMAE
Number of residues
309
Molecular Weight
33988.5
Theoretical pI
4.43
GO Classification
Functions
inorganic diphosphatase activity / manganese ion binding
Components
cytoplasm
General Function
Manganese ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011975|Manganese-dependent inorganic pyrophosphatase (ppaC)
ATGGAAAAGATACTTATTTTCGGACACCAAAACCCAGATACAGATACGATTTGTTCTGCG
ATTGCTTATGCTGATTTGAAAAACAAACTCGGCTTCAATGCTGAGCCTGTCCGCCTCGGA
CAAGTCAACGGCGAAACACAATACGCGCTTGACTATTTCAAACAAGAAAGCCCGCGTCTT
GTTGAAACAGCTGCAAACGAAGTAAACGGCGTTATCCTGGTTGACCATAACGAACGCCAG
CAAAGCATCAAAGACATTGAAGAGGTTCAGGTTTTAGAGGTTATCGACCATCACCGCATC
GCTAACTTTGAAACAGCTGAGCCGCTTTACTATCGTGCTGAGCCTGTAGGCTGTACGGCT
ACCATCTTAAACAAAATGTACAAAGAGAATAACGTGAAAATCGAGAAAGAAATTGCCGGC
CTTATGCTGTCTGCGATCATTTCTGATTCCCTGTTATTTAAATCTCCAACTTGCACGGAC
CAAGACGTAGCAGCAGCAAAAGAGCTTGCGGAGATCGCTGGAGTAGATGCTGAAGAATAC
GGCTTGAACATGTTGAAAGCAGGCGCTGATCTAAGCAAAAAAACAGTGGAAGAGCTCATT
TCTCTTGATGCGAAAGAATTTACACTCGGCAGCAAGAAAGTCGAAATCGCACAAGTAAAC
ACAGTGGACATTGAAGATGTAAAAAAACGCCAAGCTGAATTAGAAGCTGTGATCTCAAAA
GTTGTGGCTGAGAAGAATCTTGATCTGTTCCTTCTCGTTATCACAGATATCTTAGAAAAT
GATTCACTTGCTCTTGCAATCGGTAACGAAGCAGCGAAAGTGGAAAAAGCGTTCAACGTT
ACATTAGAAAACAACACAGCCCTCTTAAAAGGCGTTGTTTCCCGTAAAAAACAAGTCGTT
CCTGTCTTAACAGACGCAATGGCTGAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP37487
UniProtKB Entry NamePPAC_BACSU
GenBank Gene IDD26185
General References
  1. Ogasawara N, Nakai S, Yoshikawa H: Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin. DNA Res. 1994;1(1):1-14. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Young TW, Kuhn NJ, Wadeson A, Ward S, Burges D, Cooke GD: Bacillus subtilis ORF yybQ encodes a manganese-dependent inorganic pyrophosphatase with distinctive properties: the first of a new class of soluble pyrophosphatase? Microbiology. 1998 Sep;144 ( Pt 9):2563-71. [Article]
  4. Shintani T, Uchiumi T, Yonezawa T, Salminen A, Baykov AA, Lahti R, Hachimori A: Cloning and expression of a unique inorganic pyrophosphatase from Bacillus subtilis: evidence for a new family of enzymes. FEBS Lett. 1998 Nov 20;439(3):263-6. [Article]
  5. Ahn S, Milner AJ, Futterer K, Konopka M, Ilias M, Young TW, White SA: The "open" and "closed" structures of the type-C inorganic pyrophosphatases from Bacillus subtilis and Streptococcus gordonii. J Mol Biol. 2001 Nov 2;313(4):797-811. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails