Lipase EstA
Details
- Name
- Lipase EstA
- Synonyms
- lip
- lipA
- Lipase A
- Triacylglycerol lipase
- Gene Name
- estA
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0013022|Lipase EstA MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIGGASFNFAGIKSYLVSQ GWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKVDIVAHSMGGANTLYYIKN LDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIYSSADMIVMNYLSRLDGARNV QIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN
- Number of residues
- 212
- Molecular Weight
- 22791.075
- Theoretical pI
- 10.22
- GO Classification
- Functionstriglyceride lipase activityProcesseslipid catabolic processComponentsextracellular region
- General Function
- Triglyceride lipase activity
- Specific Function
- Active toward p-nitrophenyl esters and triacylglycerides with a marked preference for esters with C8 acyl groups.
- Pfam Domain Function
- Lipase_2 (PF01674)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013023|Lipase EstA (estA) ATGAAATTTGTAAAAAGAAGGATCATTGCACTTGTAACAATTTTGATGCTGTCTGTTACA TCGCTGTTTGCGTTGCAGCCGTCAGCAAAAGCCGCTGAACACAATCCAGTCGTTATGGTT CACGGTATTGGAGGGGCATCATTCAATTTTGCGGGAATTAAGAGCTATCTCGTATCTCAG GGCTGGTCGCGGGACAAGCTGTATGCAGTTGATTTTTGGGACAAGACAGGCACAAATTAT AACAATGGACCGGTATTATCACGATTTGTGCAAAAGGTTTTAGATGAAACGGGTGCGAAA AAAGTGGATATTGTCGCTCACAGCATGGGGGGCGCGAACACACTTTACTACATAAAAAAT CTGGACGGCGGAAATAAAGTTGCAAACGTCGTGACGCTTGGCGGCGCGAACCGTTTGACG ACAGGCAAGGCGCTTCCGGGAACAGATCCAAATCAAAAGATTTTATACACATCCATTTAC AGCAGTGCCGATATGATTGTCATGAATTACTTATCAAGATTAGATGGTGCTAGAAACGTT CAAATCCATGGCGTTGGACACATCGGCCTTCTGTACAGCAGCCAAGTCAACAGCCTGATT AAAGAAGGGCTGAACGGCGGGGGCCAGAATACGAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P37957 UniProtKB Entry Name ESTA_BACSU GenBank Protein ID 143154 GenBank Gene ID M74010 - General References
- Dartois V, Baulard A, Schanck K, Colson C: Cloning, nucleotide sequence and expression in Escherichia coli of a lipase gene from Bacillus subtilis 168. Biochim Biophys Acta. 1992 Jul 15;1131(3):253-60. [Article]
- Kumano M, Tamakoshi A, Yamane K: A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation. Microbiology. 1997 Aug;143 ( Pt 8):2775-82. [Article]
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- Lesuisse E, Schanck K, Colson C: Purification and preliminary characterization of the extracellular lipase of Bacillus subtilis 168, an extremely basic pH-tolerant enzyme. Eur J Biochem. 1993 Aug 15;216(1):155-60. [Article]
- Eggert T, van Pouderoyen G, Dijkstra BW, Jaeger KE: Lipolytic enzymes LipA and LipB from Bacillus subtilis differ in regulation of gene expression, biochemical properties, and three-dimensional structure. FEBS Lett. 2001 Aug 3;502(3):89-92. [Article]
- van Pouderoyen G, Eggert T, Jaeger KE, Dijkstra BW: The crystal structure of Bacillus subtilis lipase: a minimal alpha/beta hydrolase fold enzyme. J Mol Biol. 2001 May 25;309(1):215-26. [Article]
- Kawasaki K, Kondo H, Suzuki M, Ohgiya S, Tsuda S: Alternate conformations observed in catalytic serine of Bacillus subtilis lipase determined at 1.3 A resolution. Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1168-74. Epub 2002 Jun 20. [Article]