C->U-editing enzyme APOBEC-1

Details

Name
C->U-editing enzyme APOBEC-1
Synonyms
  • 3.5.4.36
  • Apolipoprotein B mRNA-editing enzyme 1
  • HEPR
  • mRNA(cytosine(6666)) deaminase 1
Gene Name
APOBEC1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052387|C->U-editing enzyme APOBEC-1
MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKNTTN
HVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLF
WHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPLWMMLYAL
ELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLIHPSVAWR
Number of residues
236
Molecular Weight
28191.345
Theoretical pI
Not Available
GO Classification
Functions
cytidine deaminase activity / cytosine deaminase activity / enzyme activator activity / mRNA 3'-UTR AU-rich region binding / protein domain specific binding / ribonucleoprotein complex binding / RNA binding / zinc ion binding
Processes
cellular response to insulin stimulus / cytidine to uridine editing / defense response to virus / DNA cytosine deamination / DNA demethylation / lipid metabolic process / lipoprotein biosynthetic process / lipoprotein transport / mRNA modification / mRNA processing / mRNA stabilization / negative regulation of methylation-dependent chromatin silencing / negative regulation of triglyceride metabolic process / positive regulation of mRNA modification / regulation of cell population proliferation / response to calcium ion / response to ethanol / response to gamma radiation / response to osmotic stress / response to zinc ion / RNA processing / triglyceride metabolic process
Components
cytoplasm / nucleoplasm / nucleus
General Function
Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Specific Function
Cytidine deaminase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052388|C->U-editing enzyme APOBEC-1 (APOBEC1)
ATGACTTCTGAGAAAGGTCCTTCAACCGGTGACCCCACTCTGAGGAGAAGAATCGAACCC
TGGGAGTTTGACGTCTTCTATGACCCCAGAGAACTTCGTAAAGAGGCCTGTCTGCTCTAC
GAAATCAAGTGGGGCATGAGCCGGAAGATCTGGCGAAGCTCAGGCAAAAACACCACCAAT
CACGTGGAAGTTAATTTTATAAAAAAATTTACGTCAGAAAGAGATTTTCACCCATCCATG
AGCTGCTCCATCACCTGGTTCTTGTCCTGGAGTCCCTGCTGGGAATGCTCCCAGGCTATT
AGAGAGTTTCTGAGTCGGCACCCTGGTGTGACTCTAGTGATCTACGTAGCTCGGCTTTTT
TGGCACATGGATCAACAAAATCGGCAAGGTCTCAGGGACCTTGTTAACAGTGGAGTAACT
ATTCAGATTATGAGAGCATCAGAGTATTATCACTGCTGGAGGAATTTTGTCAACTACCCA
CCTGGGGATGAAGCTCACTGGCCACAATACCCACCTCTGTGGATGATGTTGTACGCACTG
GAGCTGCACTGCATAATTCTAAGTCTTCCACCCTGTTTAAAGATTTCAAGAAGATGGCAA
AATCATCTTACATTTTTCAGACTTCATCTTCAAAACTGCCATTACCAAACGATTCCGCCA
CACATCCTTTTAGCTACAGGGCTGATACATCCTTCTGTGGCTTGGAGATGA
Chromosome Location
12
Locus
12p13.31
External Identifiers
ResourceLink
UniProtKB IDP41238
UniProtKB Entry NameABEC1_HUMAN
HGNC IDHGNC:604
General References
  1. Hadjiagapiou C, Giannoni F, Funahashi T, Skarosi SF, Davidson NO: Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. Nucleic Acids Res. 1994 May 25;22(10):1874-9. doi: 10.1093/nar/22.10.1874. [Article]
  2. Lau PP, Zhu HJ, Baldini A, Charnsangavej C, Chan L: Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8522-6. doi: 10.1073/pnas.91.18.8522. [Article]
  3. Hirano K, Min J, Funahashi T, Baunoch DA, Davidson NO: Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. J Lipid Res. 1997 May;38(5):847-59. [Article]
  4. Fujino T, Navaratnam N, Scott J: Human apolipoprotein B RNA editing deaminase gene (APOBEC1). Genomics. 1998 Jan 15;47(2):266-75. doi: 10.1006/geno.1997.5110. [Article]
  5. Lau PP, Zhu HJ, Nakamuta M, Chan L: Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. J Biol Chem. 1997 Jan 17;272(3):1452-5. doi: 10.1074/jbc.272.3.1452. [Article]
  6. Lau PP, Chang BH, Chan L: Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. Biochem Biophys Res Commun. 2001 Apr 13;282(4):977-83. doi: 10.1006/bbrc.2001.4679. [Article]
  7. Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson NO: C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. Am J Hum Genet. 2002 Jan;70(1):38-50. doi: 10.1086/337952. Epub 2001 Nov 27. [Article]
  8. Sun H, Samarghandi A, Zhang N, Yao Z, Xiong M, Teng BB: Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1585-95. doi: 10.1161/ATVBAHA.112.250043. Epub 2012 May 10. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14533Zinc chlorideapproved, investigationalunknowncofactorchelatorDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknowncofactorchelatorDetails