C->U-editing enzyme APOBEC-1
Details
- Name
- C->U-editing enzyme APOBEC-1
- Synonyms
- 3.5.4.36
- Apolipoprotein B mRNA-editing enzyme 1
- HEPR
- mRNA(cytosine(6666)) deaminase 1
- Gene Name
- APOBEC1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052387|C->U-editing enzyme APOBEC-1 MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKNTTN HVEVNFIKKFTSERDFHPSMSCSITWFLSWSPCWECSQAIREFLSRHPGVTLVIYVARLF WHMDQQNRQGLRDLVNSGVTIQIMRASEYYHCWRNFVNYPPGDEAHWPQYPPLWMMLYAL ELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLIHPSVAWR
- Number of residues
- 236
- Molecular Weight
- 28191.345
- Theoretical pI
- Not Available
- GO Classification
- Functionscytidine deaminase activity / cytosine deaminase activity / enzyme activator activity / mRNA 3'-UTR AU-rich region binding / protein domain specific binding / ribonucleoprotein complex binding / RNA binding / zinc ion bindingProcessescellular response to insulin stimulus / cytidine to uridine editing / defense response to virus / DNA cytosine deamination / DNA demethylation / lipid metabolic process / lipoprotein biosynthetic process / lipoprotein transport / mRNA modification / mRNA processing / mRNA stabilization / negative regulation of methylation-dependent chromatin silencing / negative regulation of triglyceride metabolic process / positive regulation of mRNA modification / regulation of cell population proliferation / response to calcium ion / response to ethanol / response to gamma radiation / response to osmotic stress / response to zinc ion / RNA processing / triglyceride metabolic processComponentscytoplasm / nucleoplasm / nucleus
- General Function
- Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
- Specific Function
- Cytidine deaminase activity
- Pfam Domain Function
- APOBEC4_like (PF18774)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052388|C->U-editing enzyme APOBEC-1 (APOBEC1) ATGACTTCTGAGAAAGGTCCTTCAACCGGTGACCCCACTCTGAGGAGAAGAATCGAACCC TGGGAGTTTGACGTCTTCTATGACCCCAGAGAACTTCGTAAAGAGGCCTGTCTGCTCTAC GAAATCAAGTGGGGCATGAGCCGGAAGATCTGGCGAAGCTCAGGCAAAAACACCACCAAT CACGTGGAAGTTAATTTTATAAAAAAATTTACGTCAGAAAGAGATTTTCACCCATCCATG AGCTGCTCCATCACCTGGTTCTTGTCCTGGAGTCCCTGCTGGGAATGCTCCCAGGCTATT AGAGAGTTTCTGAGTCGGCACCCTGGTGTGACTCTAGTGATCTACGTAGCTCGGCTTTTT TGGCACATGGATCAACAAAATCGGCAAGGTCTCAGGGACCTTGTTAACAGTGGAGTAACT ATTCAGATTATGAGAGCATCAGAGTATTATCACTGCTGGAGGAATTTTGTCAACTACCCA CCTGGGGATGAAGCTCACTGGCCACAATACCCACCTCTGTGGATGATGTTGTACGCACTG GAGCTGCACTGCATAATTCTAAGTCTTCCACCCTGTTTAAAGATTTCAAGAAGATGGCAA AATCATCTTACATTTTTCAGACTTCATCTTCAAAACTGCCATTACCAAACGATTCCGCCA CACATCCTTTTAGCTACAGGGCTGATACATCCTTCTGTGGCTTGGAGATGA
- Chromosome Location
- 12
- Locus
- 12p13.31
- External Identifiers
Resource Link UniProtKB ID P41238 UniProtKB Entry Name ABEC1_HUMAN HGNC ID HGNC:604 - General References
- Hadjiagapiou C, Giannoni F, Funahashi T, Skarosi SF, Davidson NO: Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. Nucleic Acids Res. 1994 May 25;22(10):1874-9. doi: 10.1093/nar/22.10.1874. [Article]
- Lau PP, Zhu HJ, Baldini A, Charnsangavej C, Chan L: Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8522-6. doi: 10.1073/pnas.91.18.8522. [Article]
- Hirano K, Min J, Funahashi T, Baunoch DA, Davidson NO: Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. J Lipid Res. 1997 May;38(5):847-59. [Article]
- Fujino T, Navaratnam N, Scott J: Human apolipoprotein B RNA editing deaminase gene (APOBEC1). Genomics. 1998 Jan 15;47(2):266-75. doi: 10.1006/geno.1997.5110. [Article]
- Lau PP, Zhu HJ, Nakamuta M, Chan L: Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. J Biol Chem. 1997 Jan 17;272(3):1452-5. doi: 10.1074/jbc.272.3.1452. [Article]
- Lau PP, Chang BH, Chan L: Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. Biochem Biophys Res Commun. 2001 Apr 13;282(4):977-83. doi: 10.1006/bbrc.2001.4679. [Article]
- Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson NO: C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. Am J Hum Genet. 2002 Jan;70(1):38-50. doi: 10.1086/337952. Epub 2001 Nov 27. [Article]
- Sun H, Samarghandi A, Zhang N, Yao Z, Xiong M, Teng BB: Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1585-95. doi: 10.1161/ATVBAHA.112.250043. Epub 2012 May 10. [Article]