DNA ligase
Details
- Name
- DNA ligase
- Synonyms
- 6.5.1.2
- lig
- ligN
- Polydeoxyribonucleotide synthase [NAD(+)]
- Gene Name
- ligA
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Amino acid sequence
>lcl|BSEQ0007240|DNA ligase MTNIQTQLDNLRKTLRQYEYEYHVLDNPSVPDSEYDRLFHQLKALELEHPEFLTSDSPTQ RVGAKPLSGFSQIRHEIPMLSLDNAFSDAEFNAFVKRIEDRLILLPKPLTFCCEPKLDGL AVSILYVNGELTQAATRGDGTTGEDITANIRTIRNVPLQLLTDNPPARLEVRGEVFMPHA GFERLNKYALEHNEKTFANPRNAAAGSLRQLDPNITSKRPLVLNAYGIGIAEGVDLPTTH YARLQWLKSIGIPVNPEIRLCNGADEVLGFYRDIQNKRSSLGYDIDGTVLKINDIALQNE LGFISKAPRWAIAYKFPAQEELTLLNDVEFQVGRTGAITPVAKLEPVFVAGVTVSNATLH NGDEIERLNIAIGDTVVIRRAGDVIPQIIGVLHERRPDNAKPIIFPTNCPVCDSQIIRIE GEAVARCTGGLFCAAQRKEALKHFVSRKAMDIDGVGGKLIEQLVDRELIHTPADLFKLDL TTLTRLERMGAKSAENALNSLENAKSTTLARFIFALGIREVGEATALNLANHFKTLDALK DANLEELQQVPDVGEVVANRIFIFWREAHNVAVVEDLIAQGVHWETVEVKEASENLFKDK TVVLTGTLTQMGRNEAKALLQQLGAKVSGSVSSKTDFVIAGDAAGSKLAKAQELNITVLT EEEFLAQITR
- Number of residues
- 670
- Molecular Weight
- 74041.775
- Theoretical pI
- 5.46
- GO Classification
- FunctionsDNA binding / DNA ligase (NAD+) activity / metal ion bindingProcessesDNA repair / DNA replication
- General Function
- Metal ion binding
- Specific Function
- DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012635|DNA ligase (ligA) ATGACAAATATTCAAACTCAACTAGACAATCTACGCAAAACCTTGCGCCAATATGAATAC GAATACCACGTTTTAGATAATCCGAGTGTGCCTGATAGCGAATACGATCGTTTATTTCAT CAGCTCAAAGCCCTAGAATTAGAGCATCCTGAATTTCTGACGTCAGATTCGCCCACTCAA CGTGTTGGTGCAAAACCACTTTCTGGGTTTAGCCAAATTCGTCACGAAATTCCTATGCTC TCTTTGGATAATGCTTTTTCCGATGCAGAATTTAATGCTTTTGTAAAACGCATTGAAGAT CGTTTAATCCTATTACCGAAACCACTTACTTTCTGTTGCGAACCTAAACTTGATGGCTTG GCTGTGAGTATTTTGTATGTTAATGGTGAACTTACACAAGCCGCCACTCGTGGTGATGGC ACCACAGGCGAAGATATTACAGCCAATATCCGCACGATTCGTAATGTTCCATTGCAACTT TTAACAGATAATCCTCCAGCACGTTTAGAGGTGCGGGGCGAAGTTTTTATGCCGCACGCA GGCTTTGAGCGTTTAAATAAATATGCGTTAGAACATAATGAAAAAACCTTTGCTAATCCT CGCAATGCAGCGGCAGGCTCTTTACGCCAGCTTGATCCTAATATTACCAGCAAACGTCCG CTGGTATTAAATGCTTATGGTATTGGAATTGCTGAGGGGGTTGATCTGCCGACTACGCAT TATGCTCGTTTGCAATGGCTAAAATCTATCGGGATTCCAGTAAATCCTGAAATTCGTTTA TGCAATGGTGCAGATGAAGTTTTAGGTTTTTATCGAGATATTCAAAACAAACGTAGCTCG TTAGGTTATGATATTGACGGAACGGTATTAAAAATCAATGATATAGCCTTACAAAATGAA CTAGGATTTATTTCTAAAGCACCTCGCTGGGCGATTGCTTATAAATTCCCCGCCCAAGAA GAATTAACCCTGTTGAATGATGTTGAATTCCAAGTGGGTCGAACTGGCGCAATCACACCA GTTGCCAAATTAGAGCCAGTGTTTGTTGCAGGCGTTACAGTAAGTAATGCCACCTTACAT AATGGCGATGAAATTGAACGTTTAAATATCGCTATTGGCGATACTGTTGTTATTCGTCGA GCAGGCGATGTAATTCCACAAATTATTGGCGTATTACACGAACGTCGCCCTGATAATGCT AAACCAATCATTTTCCCAACAAATTGCCCTGTGTGCGATTCTCAAATTATTCGTATTGAA GGCGAAGCAGTAGCACGTTGCACGGGAGGATTATTCTGTGCGGCACAGCGTAAAGAGGCG TTAAAACATTTCGTCTCTCGTAAAGCAATGGATATTGATGGTGTAGGCGGAAAATTAATA GAGCAATTAGTCGATCGAGAACTGATTCATACACCTGCGGACTTATTTAAACTTGATTTA ACCACGCTCACACGCTTAGAAAGAATGGGTGCAAAATCTGCAGAAAACGCTCTCAATAGT CTTGAAAATGCAAAAAGCACGACGCTTGCTCGCTTTATTTTTGCTTTAGGCATTCGTGAA GTGGGCGAAGCCACTGCATTAAATCTTGCTAATCATTTCAAAACTTTAGATGCGCTTAAA GACGCAAATCTTGAAGAACTTCAACAAGTGCCTGATGTAGGGGAAGTTGTAGCGAACCGA ATTTTTATATTTTGGCGTGAAGCGCATAATGTTGCAGTCGTGGAGGATTTAATCGCACAA GGTGTGCATTGGGAAACTGTAGAAGTGAAAGAAGCAAGTGAAAACTTGTTCAAAGATAAA ACTGTAGTACTGACAGGCACTCTTACACAAATGGGGCGTAATGAAGCAAAAGCCTTATTA CAACAGCTTGGTGCAAAAGTAAGTGGTTCGGTATCCAGTAAAACAGATTTCGTTATCGCA GGTGATGCAGCAGGCTCTAAACTTGCAAAAGCTCAAGAACTAAATATTACAGTACTAACA GAAGAAGAATTTTTAGCACAGATAACAAGATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P43813 UniProtKB Entry Name DNLJ_HAEIN GenBank Protein ID 3212176 GenBank Gene ID L42023 - General References
- Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]