Shikimate dehydrogenase (NADP(+))
Details
- Name
- Shikimate dehydrogenase (NADP(+))
- Synonyms
- 1.1.1.25
- SDH
- Gene Name
- aroE
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Amino acid sequence
>lcl|BSEQ0016436|Shikimate dehydrogenase (NADP(+)) MDLYAVWGNPIAQSKSPLIQNKLAAQTHQTMEYIAKLGDLDAFEQQLLAFFEEGAKGCNI TSPFKERAYQLADEYSQRAKLAEACNTLKKLDDGKLYADNTDGIGLVTDLQRLNWLRPNQ HVLILGAGGATKGVLLPLLQAQQNIVLANRTFSKTKELAERFQPYGNIQAVSMDSIPLQT YDLVINATSAGLSGGTASVDAEILKLGSAFYDMQYAKGTDTPFIALCKSLGLTNVSDGFG MLVAQAAHSFHLWRGVMPDFVSVYEQLKKAML
- Number of residues
- 272
- Molecular Weight
- 29759.815
- Theoretical pI
- 6.12
- GO Classification
- FunctionsNADP binding / shikimate 3-dehydrogenase (NADP+) activityProcessesaromatic amino acid family biosynthetic process / chorismate biosynthetic process / shikimate metabolic process
- General Function
- Shikimate 3-dehydrogenase (nadp+) activity
- Specific Function
- Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016437|Shikimate dehydrogenase (NADP(+)) (aroE) ATGGATCTTTATGCTGTGTGGGGCAATCCGATTGCGCAAAGTAAATCGCCGTTAATTCAA AATAAGTTAGCCGCACAAACCCATCAAACTATGGAATACATTGCAAAATTAGGCGATCTT GATGCTTTTGAACAACAGCTTTTGGCATTTTTTGAGGAGGGTGCGAAAGGTTGCAATATT ACTTCGCCTTTTAAAGAACGCGCTTATCAGCTGGCAGACGAATATAGCCAACGAGCAAAA CTGGCGGAAGCCTGTAATACGCTAAAAAAACTCGATGATGGAAAACTTTATGCGGATAAC ACTGATGGGATTGGCTTAGTGACGGATTTACAACGTTTAAATTGGCTTCGTCCAAATCAG CACGTATTAATCTTGGGGGCGGGCGGAGCAACAAAAGGCGTATTATTGCCACTTTTACAA GCTCAACAAAACATTGTGCTTGCTAACCGCACTTTTTCGAAAACCAAAGAATTAGCTGAA AGATTTCAGCCTTACGGCAATATTCAAGCTGTCTCTATGGATTCGATTCCGCTACAAACT TATGATTTGGTGATTAATGCAACTTCCGCTGGATTAAGTGGTGGAACGGCTTCAGTTGAT GCTGAAATTTTAAAATTGGGCTCGGCTTTTTATGATATGCAATATGCGAAAGGCACAGAC ACGCCATTTATTGCATTATGCAAAAGTTTAGGTTTAACCAATGTTAGCGATGGCTTTGGA ATGTTAGTCGCACAAGCAGCACATTCTTTCCATTTATGGCGAGGCGTAATGCCAGATTTT GTCTCGGTTTATGAACAGCTTAAAAAGGCGATGTTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P43876 UniProtKB Entry Name AROE_HAEIN GenBank Protein ID 1573653 GenBank Gene ID L42023 - General References
- Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
- Ye S, Von Delft F, Brooun A, Knuth MW, Swanson RV, McRee DE: The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode. J Bacteriol. 2003 Jul;185(14):4144-51. [Article]