tRNA (cmo5U34)-methyltransferase

Details

Name

tRNA (cmo5U34)-methyltransferase

Synonyms

• 2.1.1.-

Gene Name

cmoA

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Amino acid sequence

>lcl|BSEQ0016608|tRNA (cmo5U34)-methyltransferase
MVKDTLFSTPIAKLGDFIFDENVAEVFPDMIQRSVPGYSNIITAIGMLAERFVTADSNVY
DLGCSRGAATLSARRNINQPNVKIIGIDNSQPMVERCRQHIAAYHSEIPVEILCNDIRHV
EIKNASMVILNFTLQFLPPEDRIALLTKIYEGLNPNGVLVLSEKFRFEDTKINHLLIDLH
HQFKRANGYSELEVSQKRTALENVMRTDSIETHKVRLKNVGFSQVELWFQCFNFGSMIAV
K

Number of residues

241

Molecular Weight

27371.3

Theoretical pI

6.87

GO Classification

Functions

S-adenosylmethionine-dependent methyltransferase activity / tRNA (uracil) methyltransferase activity

Processes

tRNA wobble uridine modification

General Function

Trna (uracil) methyltransferase activity

Specific Function

Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U).

Pfam Domain Function

• Methyltransf_12 (PF08242)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0016609|tRNA (cmo5U34)-methyltransferase (cmoA)
ATGGTAAAAGATACTCTATTTTCTACCCCCATTGCTAAATTGGGGGATTTCATCTTTGAC
GAAAACGTTGCTGAAGTCTTTCCAGATATGATTCAACGTTCCGTGCCGGGCTATTCTAAC
ATTATTACTGCAATCGGTATGCTGGCTGAACGTTTCGTCACGGCTGATAGTAACGTTTAT
GATCTAGGTTGCTCACGAGGAGCTGCCACACTTTCTGCACGTCGAAATATTAATCAACCC
AACGTAAAAATTATTGGTATCGATAATTCTCAACCGATGGTTGAACGTTGTCGCCAACAT
ATTGCGGCATATCATAGTGAGATACCAGTAGAAATTCTCTGTAATGATATTCGCCACGTT
GAAATTAAAAATGCCTCAATGGTCATTCTCAACTTCACCTTGCAATTTTTACCGCCTGAA
GATCGCATCGCATTGCTTACCAAAATCTATGAAGGTTTAAATCCAAATGGCGTATTAGTA
CTTTCTGAAAAATTCCGTTTTGAAGATACTAAAATTAATCATTTACTCATTGACTTGCAC
CATCAATTCAAACGTGCCAATGGTTATAGCGAATTAGAAGTGAGCCAAAAACGCACCGCA
CTTGAAAATGTGATGCGTACAGATTCTATCGAGACACACAAAGTGCGGTTAAAAAACGTA
GGATTTTCACAAGTAGAACTTTGGTTCCAATGCTTTAATTTTGGCTCGATGATTGCGGTT
AAATAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P43985
UniProtKB Entry Name	CMOA_HAEIN
GenBank Protein ID	1573289
GenBank Gene ID	L42023

General References

1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
2. Lim K, Zhang H, Tempczyk A, Bonander N, Toedt J, Howard A, Eisenstein E, Herzberg O: Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. Proteins. 2001 Dec 1;45(4):397-407. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03423	S-Adenosyl-L-Homoselenocysteine	experimental	unknown		Details