Rhomboid protease GlpG

Details

Name
Rhomboid protease GlpG
Synonyms
  • 3.4.21.105
  • Intramembrane serine protease
Gene Name
glpG
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Amino acid sequence
>lcl|BSEQ0012990|Rhomboid protease GlpG
MKNFLAQQGKITLILTALCVLIYLAQQLGFEDDIMYLMHYPAYEEQDSEVWRYISHTLVH
LSNLHILFNLSWFFIFGGMIERTFGSVKLLMLYVVASAITGYVQNYVSGPAFFGLSGVVY
AVLGYVFIRDKLNHHLFDLPEGFFTMLLVGIALGFISPLFGVEMGNAAHISGLIVGLIWG
FIDSKLRKNSLE
Number of residues
192
Molecular Weight
21657.295
Theoretical pI
6.39
GO Classification
Functions
identical protein binding / serine-type endopeptidase activity
Components
integral component of membrane / plasma membrane
General Function
Serine-type endopeptidase activity
Specific Function
Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Pfam Domain Function
Transmembrane Regions
11-31 58-78 83-103 108-128 142-162 164-184
Cellular Location
Cell inner membrane
Gene sequence
>lcl|BSEQ0012991|Rhomboid protease GlpG (glpG)
ATGAAAAACTTTTTAGCTCAACAAGGAAAAATCACGCTAATTCTCACCGCACTTTGTGTG
CTTATTTATCTTGCTCAACAGCTGGGTTTTGAAGACGATATTATGTATTTGATGCATTAC
CCCGCTTACGAAGAGCAAGATAGTGAAGTGTGGCGTTATATCTCACATACATTGGTACAT
TTATCTAATTTGCATATTTTGTTTAATCTGTCTTGGTTTTTTATTTTCGGTGGAATGATT
GAGCGCACTTTTGGCTCGGTTAAATTATTGATGTTGTATGTTGTAGCATCTGCCATAACA
GGATATGTGCAAAATTATGTGTCTGGCCCCGCTTTCTTTGGGCTTTCTGGTGTTGTATAT
GCGGTTCTAGGTTATGTATTTATACGTGATAAATTGAATCATCATTTATTTGATCTGCCA
GAAGGTTTTTTTACAATGTTATTGGTGGGGATCGCATTAGGTTTTATTAGCCCCTTATTT
GGTGTTGAAATGGGAAATGCTGCACATATTTCAGGCTTGATTGTCGGCTTGATTTGGGGA
TTTATTGATAGCAAATTGCGCAAAAATTCGCTAGAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP44783
UniProtKB Entry NameGLPG_HAEIN
GenBank Protein ID3212176
GenBank Gene IDL42023
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
  2. Lemieux MJ, Fischer SJ, Cherney MM, Bateman KS, James MN: The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):750-4. Epub 2007 Jan 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08367(R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATEexperimentalunknownDetails