DNA gyrase subunit A
Details
- Name
- DNA gyrase subunit A
- Synonyms
- 5.6.2.2
- Gene Name
- gyrA
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0052700|DNA gyrase subunit A MGELAKEILPVNIEDELKQSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMSELGNDWN KPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDNAAAM RYTEVRMAKLAHELLADLEKETVDWVPNYDGTEQIPAVMPTKIPNLLVNGSSGIAVGMAT NIPPHNLGEVIDGCLALMDNPDLTVDELMQYIPGPDFPTAGIINGRAGIIEAYRTGRGRI YIRARAVVEEMEKGGGREQIIITELPYQLNKARLIEKIAELVKEKKIEGISELRDESDKD GMRVVIELRRGEVGEVVLNNLYAQTQLQSVFGINVVALVDGQPRTLNLKDMLEVFVRHRR EVVTRRTVYELRKARERGHILEGQAVALSNIDPVIELIKSSPTPAEAKERLIATAWESSA VEAMVERAGADACRPEDLDPQYGLRDGKYYLSPEQAQAILELRLHRLTGLEHEKLLSEYQ EILNLIGELIRILTNPARLMEVIREELEAVKAEFGDARRTEIVASQVDLTIADLITEEDR VVTISHGGYAKSQPLAAYQAQRRGGKGKSATGMKDEDYIEHLLVANSHATLLLFSSKGKV YWLRTFEIPEASRTARGRPLVNLLPLDEGERITAMLQIDLEALQQNGGADDDLDEAEGAV LEGEVVEAAEVEEVEGETAELVAEPTGAYIFMATAFGTVKKTPLVQFSRPRSSGLIALKL EEGDTLIAAAITDGAKEVMLFSSAGKVIRFAESVVRIMGRNARGVRGMRLGKGQQLISML IPESGAQILTASERGFGKRTPLSKFPRRGRGGQGVIAMVTNERNGALIAAVQVQEGEEIM LISDQGTLVRTRVDEVSLSGRNTQGVTLIKLASDEVLVGLERVQEPSGGDDEDLPEGEEA AESLGESAESESEPAAEAEGNEE
- Number of residues
- 923
- Molecular Weight
- 101134.12
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / DNA binding / DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityProcessesDNA topological change / DNA-dependent DNA replicationComponentschromosome / cytoplasm / DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
- General Function
- A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052701|DNA gyrase subunit A (gyrA) ATGGGCGAACTGGCCAAAGAAATTCTCCCGGTCAATATCGAAGACGAGCTGAAACAGTCC TATCTCGACTACGCGATGAGCGTGATCGTCGGGCGGGCCCTGCCGGATGCACGTGACGGC CTGAAGCCGGTGCACCGCCGTGTGCTTTATGCCATGAGCGAGCTGGGCAACGACTGGAAC AAGCCCTACAAGAAATCCGCCCGTGTGGTCGGCGACGTGATCGGTAAGTACCACCCGCAC GGCGACACCGCGGTCTACGACACCATCGTGCGCATGGCGCAGCCGTTCTCGCTGCGCTAC ATGCTGGTAGACGGCCAGGGCAACTTCGGTTCGGTGGACGGCGACAACGCCGCAGCCATG CGATACACCGAAGTGCGCATGGCCAAGCTGGCCCACGAACTGCTGGCGGACCTGGAAAAG GAAACCGTCGACTGGGTGCCCAACTACGATGGCACCGAGCAGATCCCGGCGGTCATGCCG ACCAAGATTCCCAACCTGCTGGTCAACGGTTCCAGCGGTATCGCCGTGGGCATGGCGACC AACATCCCGCCGCACAACCTCGGCGAAGTGATCGACGGCTGCCTGGCGCTGATGGACAAC CCCGACCTGACCGTCGATGAGCTGATGCAGTACATCCCCGGTCCGGACTTCCCCACCGCC GGCATCATCAACGGCCGCGCCGGGATCATCGAGGCCTACCGCACCGGTCGCGGGCGCATC TACATCCGTGCCCGCGCCGTCGTCGAGGAGATGGAGAAGGGCGGCGGTCGCGAGCAGATT ATCATCACCGAGCTGCCGTACCAGTTGAACAAGGCGCGGTTGATCGAGAAGATCGCCGAG CTGGTGAAAGAGAAGAAGATCGAGGGTATTTCCGAGCTGCGCGACGAGTCTGACAAGGAC GGCATGCGCGTGGTCATCGAGCTGCGTCGCGGCGAGGTGGGCGAGGTGGTCCTCAACAAC CTCTATGCCCAGACCCAGCTGCAGAGCGTGTTCGGCATCAACGTGGTGGCCCTGGTCGAC GGCCAGCCGCGCACGCTGAACCTGAAGGACATGCTCGAGGTGTTCGTCCGCCACCGCCGC GAAGTGGTGACCCGGCGTACCGTCTACGAGCTGCGCAAGGCCCGCGAGCGCGGGCACATC CTGGAAGGCCAGGCGGTCGCCCTGTCGAACATCGACCCGGTGATCGAGCTGATCAAGAGT TCGCCGACCCCGGCCGAGGCCAAGGAACGCCTGATCGCCACTGCCTGGGAGTCCAGCGCG GTGGAAGCGATGGTCGAGCGTGCCGGCGCCGACGCCTGTCGTCCGGAAGACCTGGATCCG CAGTACGGCCTGCGCGACGGCAAGTACTACCTGTCGCCGGAGCAGGCCCAGGCGATCCTC GAGCTGCGCCTGCATCGCCTGACCGGCCTGGAGCACGAGAAGCTGCTCTCCGAATACCAG GAAATCCTCAACCTGATCGGCGAGCTGATCCGCATCCTGACCAACCCGGCGCGCCTGATG GAGGTGATCCGTGAGGAACTGGAAGCGGTCAAGGCCGAATTCGGCGATGCTCGCCGCACC GAGATCGTGGCTTCCCAGGTCGACCTGACCATCGCCGACCTGATCACCGAGGAAGACCGC GTGGTGACCATCTCGCACGGCGGCTACGCCAAGTCCCAGCCGCTGGCCGCCTACCAGGCG CAGCGTCGCGGCGGCAAAGGCAAGTCCGCCACCGGGATGAAGGACGAGGACTACATCGAA CACCTGCTGGTGGCCAACAGCCATGCGACCCTCCTGCTGTTCTCCAGCAAGGGCAAGGTC TACTGGCTGCGTACCTTCGAGATTCCGGAAGCCTCGCGTACCGCGCGTGGCCGGCCGCTG GTGAACCTGCTGCCGCTGGATGAGGGCGAGCGGATCACCGCGATGTTGCAGATCGACCTG GAGGCGCTGCAGCAGAACGGTGGCGCCGATGACGACCTCGACGAAGCCGAAGGCGCGGTG CTCGAGGGCGAGGTGGTCGAGGCCGCCGAGGTCGAGGAAGTCGAGGGCGAGACCGCCGAG CTGGTGGCCGAGCCGACCGGCGCCTACATCTTCATGGCCACCGCCTTCGGTACCGTGAAG AAGACCCCGCTGGTGCAGTTCAGCCGTCCGCGCAGCAGCGGCCTGATCGCGCTCAAGCTG GAAGAGGGCGACACCCTGATCGCCGCCGCGATCACCGATGGCGCCAAGGAAGTCATGCTG TTCTCCAGCGCCGGCAAGGTGATCCGCTTCGCCGAGAGCGTGGTGCGCATCATGGGCCGC AACGCCCGCGGCGTACGTGGCATGCGCCTGGGCAAGGGGCAGCAGCTGATCTCCATGCTG ATTCCGGAGTCCGGGGCGCAGATCCTCACCGCCTCCGAGCGCGGCTTCGGCAAGCGTACC CCGCTGAGCAAGTTCCCGCGTCGCGGCCGCGGCGGCCAGGGGGTGATCGCCATGGTCACC AACGAGCGCAACGGCGCGCTGATCGCCGCGGTACAGGTCCAGGAAGGCGAGGAGATCATG CTGATTTCCGACCAGGGCACCCTGGTGCGGACGCGTGTCGACGAAGTCTCCCTGTCCGGC CGCAATACCCAGGGCGTAACCCTGATCAAGCTCGCCAGCGACGAGGTACTGGTCGGTCTG GAGCGTGTCCAGGAGCCGTCGGGCGGAGATGACGAGGACCTGCCCGAGGGCGAGGAAGCT GCCGAATCTCTGGGCGAGTCGGCCGAGTCCGAGTCCGAGCCCGCGGCGGAAGCGGAAGGC AACGAAGAGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P48372 UniProtKB Entry Name GYRA_PSEAE - General References
- Kureishi A, Diver JM, Beckthold B, Schollaardt T, Bryan LE: Cloning and nucleotide sequence of Pseudomonas aeruginosa DNA gyrase gyrA gene from strain PAO1 and quinolone-resistant clinical isolates. Antimicrob Agents Chemother. 1994 Sep;38(9):1944-52. doi: 10.1128/AAC.38.9.1944. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details