DNA primase small subunit
Details
- Name
- DNA primase small subunit
- Synonyms
- 2.7.7.102
- DNA primase 49 kDa subunit
- p49
- Gene Name
- PRIM1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052813|DNA primase small subunit METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSF NNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRR CCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSA VRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESW DKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQY CFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAI STNEEEKEENEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSDLQKDF
- Number of residues
- 420
- Molecular Weight
- 49901.635
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA primase activity / magnesium ion binding / ribonucleotide binding / zinc ion bindingProcessesDNA replication initiation / DNA replication, synthesis of RNA primerComponentsalpha DNA polymerase / membrane / nucleoplasm
- General Function
- Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144, PubMed:24043831, PubMed:26975377, PubMed:25550159, PubMed:31479243, PubMed:33060134). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs) (PubMed:26975377). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (PubMed:25550159, PubMed:26975377). Binds single stranded DNA (By similarity).
- Specific Function
- Dna primase activity
- Pfam Domain Function
- DNA_primase_S (PF01896)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052814|DNA primase small subunit (PRIM1) ATGGAGACGTTTGACCCCACCGAGCTGCCCGAGCTGCTTAAACTTTATTACCGGAGGCTC TTTCCCTACTCTCAGTACTATCGCTGGCTCAACTACGGTGGAGTGATAAAGAATTACTTT CAACACCGTGAATTTTCATTCACATTGAAAGATGATATTTACATTCGCTACCAATCCTTC AACAACCAGAGTGATCTGGAAAAGGAGATGCAGAAAATGAATCCATACAAGATTGATATA GGCGCAGTATATTCTCACAGACCCAATCAACACAATACAGTGAAGCTGGGAGCTTTCCAG GCTCAGGAAAAAGAACTGGTATTTGACATTGACATGACAGACTATGACGATGTGAGGAGA TGTTGTAGTTCTGCAGACATATGTCCTAAGTGCTGGACCCTCATGACAATGGCCATACGC ATCATTGACAGAGCATTGAAGGAGGACTTTGGATTTAAGCATCGTCTCTGGGTATATTCT GGAAGGAGAGGTGTTCATTGTTGGGTCTGTGATGAATCAGTTAGAAAACTGTCTTCTGCA GTACGTTCTGGGATAGTTGAGTATTTGAGCCTTGTAAAGGGTGGTCAAGACGTTAAAAAG AAAGTTCACCTAAGTGAAAAAATTCACCCTTTTATCAGAAAATCTATAAACATAATAAAA AAATACTTTGAAGAATATGCCTTGGTTAATCAAGATATTCTCGAAAATAAAGAAAGCTGG GATAAGATTTTAGCCCTTGTTCCTGAAACAATTCATGATGAACTTCAACAAAGCTTCCAA AAGTCTCACAATTCACTTCAGCGTTGGGAGCACTTGAAGAAAGTAGCCAGCAGATATCAG AATAACATCAAAAATGACAAATATGGACCCTGGCTGGAGTGGGAGATTATGCTCCAGTAC TGTTTTCCACGGCTGGATATCAATGTCAGCAAAGGAATCAATCATCTACTGAAGAGCCCT TTTAGTGTTCATCCTAAAACAGGTCGCATATCTGTGCCTATTGATTTGCAGAAAGTGGAC CAGTTTGATCCATTTACTGTTCCGACCATAAGCTTCATCTGCCGTGAATTGGATGCCATT TCCACTAATGAAGAGGAAAAAGAGGAGAATGAAGCTGAATCTGATGTCAAACATAGAACC AGAGATTATAAGAAGACCAGTCTAGCACCTTATGTGAAAGTTTTTGAACATTTTCTTGAA AATCTGGATAAATCCCGAAAAGGAGAACTTCTTAAGAAGAGTGATTTACAAAAAGATTTC TGA
- Chromosome Location
- 12
- Locus
- 12q13.3
- External Identifiers
Resource Link UniProtKB ID P49642 UniProtKB Entry Name PRI1_HUMAN HGNC ID HGNC:9369 - General References
- Not Available