Methylmalonyl-CoA decarboxylase
Details
- Name
- Methylmalonyl-CoA decarboxylase
- Synonyms
- 4.1.1.41
- mmcD
- Transcarboxylase
- ygfG
- Gene Name
- scpB
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0003166|Methylmalonyl-CoA decarboxylase MSYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSK VFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDL IIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNH VVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDS EDYQEGMNAFLEKRKPNFVGH
- Number of residues
- 261
- Molecular Weight
- 29172.33
- Theoretical pI
- 6.04
- GO Classification
- Functionscarboxy-lyase activity / methylmalonyl-CoA decarboxylase activityComponentscytosol
- General Function
- Methylmalonyl-coa decarboxylase activity
- Specific Function
- Catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propionate.
- Pfam Domain Function
- ECH_1 (PF00378)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019141|Methylmalonyl-CoA decarboxylase (scpB) ATGTCTTATCAGTATGTTAACGTTGTCACTATCAACAAAGTGGCGGTCATTGAGTTTAAC TATGGCCGAAAACTTAATGCCTTAAGTAAAGTCTTTATTGATGATCTTATGCAGGCGTTA AGCGATCTCAACCGGCCGGAAATTCGCTGTATCATTTTGCGCGCACCGAGTGGATCCAAA GTCTTCTCCGCAGGTCACGATATTCACGAACTGCCGTCTGGCGGTCGCGATCCGCTCTCC TATGATGATCCATTGCGTCAAATCACCCGCATGATCCAAAAATTCCCGAAACCGATCATT TCGATGGTGGAAGGTAGTGTTTGGGGTGGCGCATTTGAAATGATCATGAGTTCCGATCTG ATCATCGCCGCCAGTACCTCAACCTTCTCAATGACGCCTGTAAACCTCGGCGTCCCGTAT AACCTGGTCGGCATTCACAACCTGACCCGCGACGCGGGCTTCCACATTGTCAAAGAGCTG ATTTTTACCGCTTCGCCAATCACCGCCCAGCGCGCGCTGGCTGTCGGCATCCTCAACCAT GTTGTGGAAGTGGAAGAACTGGAAGATTTCACCTTACAAATGGCGCACCACATCTCTGAG AAAGCGCCGTTAGCCATTGCCGTTATCAAAGAAGAGCTGCGTGTACTGGGCGAAGCACAC ACCATGAACTCCGATGAATTTGAACGTATTCAGGGGATGCGCCGCGCGGTGTATGACAGC GAAGATTACCAGGAAGGGATGAACGCTTTCCTCGAAAAACGTAAACCTAATTTCGTTGGT CATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P52045 UniProtKB Entry Name SCPB_ECOLI GenBank Protein ID 882447 GenBank Gene ID U28377 - General References
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Haller T, Buckel T, Retey J, Gerlt JA: Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4622-9. [Article]
- Benning MM, Haller T, Gerlt JA, Holden HM: New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli. Biochemistry. 2000 Apr 25;39(16):4630-9. [Article]