Calcium-dependent protein kinase 1

Details

Name

Calcium-dependent protein kinase 1

Synonyms

• 2.7.11.1
• CDPK1

Gene Name

CPK1

Organism

Plasmodium falciparum (isolate 3D7)

Amino acid sequence

>lcl|BSEQ0051636|Calcium-dependent protein kinase 1
MGCSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNSEDLAINPGMYVRKKEGKIGESYFKVR
KLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLL
KSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGIC
YLHKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVL
RKKYNEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKE
LIKLMLTYDYNKRITAKEALNSKWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAA
ILFIGSKLTTLEERKELTDIFKKLDKNGDGQLDKKELIEGYNILRSFKNELGELKNVEEE
VDNILKEVDFDKNGYIEYSEFISVCMDKQILFSEERLRDAFNLFDTDKSGKITKEELANL
FGLTSISEQMWNEVLGEADKNKDNMIDFDEFVNMMHKICDNKSS

Number of residues

524

Molecular Weight

60799.015

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / calcium ion binding / calcium-dependent protein serine/threonine kinase activity / calmodulin binding / calmodulin-dependent protein kinase activity / protein serine/threonine kinase activity

Processes

intracellular signal transduction / peptidyl-serine phosphorylation / protein autophosphorylation / protein phosphorylation / response to drug

Components

cytoplasm / nucleus / plasma membrane

General Function

Calcium-dependent kinase which may phosphorylate proteins of the host erythrocyte membranes.

Specific Function

Atp binding

Pfam Domain Function

• Pkinase (PF00069)
• EF-hand_7 (PF13499)

Transmembrane Regions

Not Available

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0051637|Calcium-dependent protein kinase 1 (CPK1)
ATGGGGTGTTCACAAAGTTCAAACGTGAAAGATTTTAAAACGAGGAGAAGTAAATTTACG
AATGGAAATAATTATGGGAAAAGTGGTAATAATAAAAATTCGGAGGACCTAGCGATAAAC
CCAGGTATGTATGTTAGAAAAAAAGAAGGGAAGATAGGGGAGTCCTATTTCAAAGTTCGC
AAATTAGGTAGCGGTGCGTACGGAGAAGTATTATTGTGTAGAGAAAAACATGGACATGGT
GAGAAGGCTATTAAGGTTATAAAGAAGTCCCAATTTGATAAGATGAAATATTCGATAACA
AATAAGATCGAATGTGATGATAAAATACATGAAGAAATATATAATGAGATATCATTATTA
AAATCATTAGATCATCCTAATATAATAAAATTGTTTGATGTTTTTGAAGATAAGAAATAT
TTTTATTTAGTAACCGAATTTTATGAAGGTGGGGAATTATTTGAACAAATTATTAATCGT
CATAAATTTGATGAATGTGATGCTGCTAATATAATGAAACAAATATTAAGTGGCATATGT
TATTTACATAAACATAATATTGTACATCGAGATATTAAACCAGAAAATATTTTATTAGAA
AATAAACATAGTTTATTAAATATAAAAATTGTCGATTTTGGTTTATCTTCCTTTTTCTCA
AAAGATAATAAGTTAAGAGATAGATTAGGTACAGCATATTATATTGCACCTGAAGTTTTG
AGGAAAAAATATAATGAAAAATGTGATGTCTGGTCATGTGGAGTTATTCTATATATCTTA
TTATGTGGTTATCCTCCTTTCGGGGGTCAGAATGATCAAGATATTATAAAAAAGGTGGAG
AAAGGAAAATATTACTTTGATTTTAATGACTGGAAAAATATAAGTGAAGAGGCAAAAGAA
TTAATCAAACTTATGTTGACATATGATTATAATAAAAGAATAACAGCAAAGGAAGCTCTA
AATAGTAAATGGATAAAAAAATATGCAAACAATATTAATAAAAGTGATCAAAAAACTTTA
TGTGGCGCTTTATCAAATATGAGGAAATTTGAGGGCAGTCAGAAATTAGCTCAAGCAGCC
ATATTATTTATTGGAAGTAAATTAACAACATTAGAGGAACGTAAAGAGCTTACTGACATT
TTTAAAAAGTTGGATAAAAATGGCGATGGCCAGCTTGATAAGAAGGAATTGATTGAGGGA
TACAACATACTTAGGAGCTTTAAGAATGAGTTAGGAGAACTTAAAAATGTCGAGGAAGAA
GTAGACAATATATTGAAGGAGGTTGATTTTGATAAAAATGGATACATAGAATATTCAGAG
TTTATTTCTGTATGTATGGATAAGCAAATCCTTTTCAGTGAGGAGAGATTAAGAGATGCA
TTCAATTTGTTTGATACTGATAAAAGTGGAAAAATAACGAAGGAAGAATTAGCAAATTTA
TTTGGTTTGACATCCATAAGTGAACAAATGTGGAATGAAGTTCTCGGAGAAGCAGATAAA
AATAAAGATAACATGATTGACTTTGATGAATTCGTTAACATGATGCACAAAATTTGTGAT
AATAAATCTTCATAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P62344
UniProtKB Entry Name	CDPK1_PLAF7

General References

1. Gardner MJ, Tettelin H, Carucci DJ, Cummings LM, Aravind L, Koonin EV, Shallom S, Mason T, Yu K, Fujii C, Pederson J, Shen K, Jing J, Aston C, Lai Z, Schwartz DC, Pertea M, Salzberg S, Zhou L, Sutton GG, Clayton R, White O, Smith HO, Fraser CM, Adams MD, Venter JC, Hoffman SL: Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science. 1998 Nov 6;282(5391):1126-32. [Article]
2. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12010	Fostamatinib	approved, investigational	unknown	inhibitor	Details