Metabotropic glutamate receptor 3
Details
- Name
- Metabotropic glutamate receptor 3
- Synonyms
- GPRC1C
- MGLUR3
- Gene Name
- GRM3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004599|Metabotropic glutamate receptor 3 MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
- Number of residues
- 879
- Molecular Weight
- 98878.05
- Theoretical pI
- 7.7
- GO Classification
- Functionscalcium channel regulator activity / G-protein coupled receptor activity / glutamate receptor activity / group II metabotropic glutamate receptor activityProcessesadenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway / negative regulation of adenylate cyclase activity / regulation of synaptic transmission, glutamatergic / synaptic transmissionComponentsaxon / dendritic spine / integral component of plasma membrane / plasma membrane / postsynaptic density / postsynaptic membrane / presynaptic membrane
- General Function
- Group ii metabotropic glutamate receptor activity
- Specific Function
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
- Pfam Domain Function
- Transmembrane Regions
- 577-599 614-634 646-664 689-709 735-756 770-792 803-828
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011682|Metabotropic glutamate receptor 3 (GRM3) ATGAAGATGTTGACAAGACTGCAAGTTCTTACCTTAGCTTTGTTTTCAAAGGGATTTTTA CTCTCTTTAGGGGACCATAACTTTCTAAGGAGAGAGATTAAAATAGAAGGTGACCTTGTT TTAGGGGGCCTGTTTCCTATTAACGAAAAAGGCACTGGAACTGAAGAATGTGGGCGAATC AATGAAGACCGAGGGATTCAACGCCTGGAAGCCATGTTGTTTGCTATTGATGAAATCAAC AAAGATGATTACTTGCTACCAGGAGTGAAGTTGGGTGTTCACATTTTGGATACATGTTCA AGGGATACCTATGCATTGGAGCAATCACTGGAGTTTGTCAGGGCATCTTTGACAAAAGTG GATGAAGCTGAGTATATGTGTCCTGATGGATCCTATGCCATTCAAGAAAACATCCCACTT CTCATTGCAGGGGTCATTGGTGGCTCTTATAGCAGTGTTTCCATACAGGTGGCAAACCTG CTGCGGCTCTTCCAGATCCCTCAGATCAGCTACGCATCCACCAGCGCCAAACTCAGTGAT AAGTCGCGCTATGATTACTTTGCCAGGACCGTGCCCCCCGACTTCTACCAGGCCAAAGCC ATGGCTGAGATCTTGCGCTTCTTCAACTGGACCTACGTGTCCACAGTAGCCTCCGAGGGT GATTACGGGGAGACAGGGATCGAGGCCTTCGAGCAGGAAGCCCGCCTGCGCAACATCTGC ATCGCTACGGCGGAGAAGGTGGGCCGCTCCAACATCCGCAAGTCCTACGACAGCGTGATC CGAGAACTGTTGCAGAAGCCCAACGCGCGCGTCGTGGTCCTCTTCATGCGCAGCGACGAC TCGCGGGAGCTCATTGCAGCCGCCAGCCGCGCCAATGCCTCCTTCACCTGGGTGGCCAGC GACGGCTGGGGCGCGCAGGAGAGCATCATCAAGGGCAGCGAGCATGTGGCCTACGGCGCC ATCACCCTGGAGCTGGCCTCCCAGCCTGTCCGCCAGTTCGACCGCTACTTCCAGAGCCTC AACCCCTACAACAACCACCGCAACCCCTGGTTCCGGGACTTCTGGGAGCAAAAGTTTCAG TGCAGCCTCCAGAACAAACGCAACCACAGGCGCGTCTGCGACAAGCACCTGGCCATCGAC AGCAGCAACTACGAGCAAGAGTCCAAGATCATGTTTGTGGTGAACGCGGTGTATGCCATG GCCCACGCTTTGCACAAAATGCAGCGCACCCTCTGTCCCAACACTACCAAGCTTTGTGAT GCTATGAAGATCCTGGATGGGAAGAAGTTGTACAAGGATTACTTGCTGAAAATCAACTTC ACGGCTCCATTCAACCCAAATAAAGATGCAGATAGCATAGTCAAGTTTGACACTTTTGGA GATGGAATGGGGCGATACAACGTGTTCAATTTCCAAAATGTAGGTGGAAAGTATTCCTAC TTGAAAGTTGGTCACTGGGCAGAAACCTTATCGCTAGATGTCAACTCTATCCACTGGTCC CGGAACTCAGTCCCCACTTCCCAGTGCAGCGACCCCTGTGCCCCCAATGAAATGAAGAAT ATGCAACCAGGGGATGTCTGCTGCTGGATTTGCATCCCCTGTGAACCCTACGAATACCTG GCTGATGAGTTTACCTGTATGGATTGTGGGTCTGGACAGTGGCCCACTGCAGACCTAACT GGATGCTATGACCTTCCTGAGGACTACATCAGGTGGGAAGACGCCTGGGCCATTGGCCCA GTCACCATTGCCTGTCTGGGTTTTATGTGTACATGCATGGTTGTAACTGTTTTTATCAAG CACAACAACACACCCTTGGTCAAAGCATCGGGCCGAGAACTCTGCTACATCTTATTGTTT GGGGTTGGCCTGTCATACTGCATGACATTCTTCTTCATTGCCAAGCCATCACCAGTCATC TGTGCATTGCGCCGACTCGGGCTGGGGAGTTCCTTCGCTATCTGTTACTCAGCCCTGCTG ACCAAGACAAACTGCATTGCCCGCATCTTCGATGGGGTCAAGAATGGCGCTCAGAGGCCA AAATTCATCAGCCCCAGTTCTCAGGTTTTCATCTGCCTGGGTCTGATCCTGGTGCAAATT GTGATGGTGTCTGTGTGGCTCATCCTGGAGGCCCCAGGCACCAGGAGGTATACCCTTGCA GAGAAGCGGGAAACAGTCATCCTAAAATGCAATGTCAAAGATTCCAGCATGTTGATCTCT CTTACCTACGATGTGATCCTGGTGATCTTATGCACTGTGTACGCCTTCAAAACGCGGAAG TGCCCAGAAAATTTCAACGAAGCTAAGTTCATAGGTTTTACCATGTACACCACGTGCATC ATCTGGTTGGCCTTCCTCCCTATATTTTATGTGACATCAAGTGACTACAGAGTGCAGACG ACAACCATGTGCATCTCTGTCAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCA CCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACACAGACTGCAC CTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACG TATGTGCCAACGGTGTGCAATGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGA
- Chromosome Location
- 7
- Locus
- 7q21.1-q21.2
- External Identifiers
Resource Link UniProtKB ID Q14832 UniProtKB Entry Name GRM3_HUMAN GenBank Protein ID 1171564 GenBank Gene ID X77748 GenAtlas ID GRM3 HGNC ID HGNC:4595 - General References
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- Sartorius LJ, Nagappan G, Lipska BK, Lu B, Sei Y, Ren-Patterson R, Li Z, Weinberger DR, Harrison PJ: Alternative splicing of human metabotropic glutamate receptor 3. J Neurochem. 2006 Feb;96(4):1139-48. Epub 2006 Jan 17. [Article]
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