P2Y purinoceptor 14

Details

Name
P2Y purinoceptor 14
Synonyms
  • G-protein coupled receptor 105
  • GPR105
  • KIAA0001
  • P2Y14
  • UDP-glucose receptor
Gene Name
P2RY14
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052233|P2Y purinoceptor 14
MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYL
KNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRY
YKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELG
RKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVF
VFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQ
PFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
Number of residues
338
Molecular Weight
38970.995
Theoretical pI
Not Available
GO Classification
Functions
G protein-coupled purinergic nucleotide receptor activity / UDP-activated nucleotide receptor activity
Processes
G protein-coupled receptor signaling pathway
Components
integral component of membrane / plasma membrane
General Function
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.
Specific Function
G protein-coupled purinergic nucleotide receptor activity
Pfam Domain Function
Transmembrane Regions
30-50 56-76 97-117 140-160 189-209 235-255 279-299
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052234|P2Y purinoceptor 14 (P2RY14)
ATGATCAATTCAACCTCCACACAGCCTCCAGATGAATCCTGCTCTCAGAACCTCCTGATC
ACTCAGCAGATCATTCCTGTGCTGTACTGTATGGTCTTCATTGCAGGAATCCTACTCAAT
GGAGTGTCAGGATGGATATTCTTTTACGTGCCCAGCTCTAAGAGTTTCATCATCTATCTC
AAGAACATTGTTATTGCTGACTTTGTGATGAGCCTGACTTTTCCTTTCAAGATCCTTGGT
GACTCAGGCCTTGGTCCCTGGCAGCTGAACGTGTTTGTGTGCAGGGTCTCTGCCGTGCTC
TTCTACGTCAACATGTACGTCAGCATTGTGTTCTTTGGGCTCATCAGCTTTGACAGATAT
TATAAAATTGTAAAGCCTCTTTGGACTTCTTTCATCCAGTCAGTGAGTTACAGCAAACTT
CTGTCAGTGATAGTATGGATGCTCATGCTCCTCCTTGCTGTTCCAAATATTATTCTCACC
AACCAGAGTGTTAGGGAGGTTACACAAATAAAATGTATAGAACTGAAAAGTGAACTGGGA
CGGAAGTGGCACAAAGCATCAAACTACATCTTCGTGGCCATCTTCTGGATTGTGTTTCTT
TTGTTAATCGTTTTCTATACTGCTATCACAAAGAAAATCTTTAAGTCCCACCTTAAGTCA
AGTCGGAATTCCACTTCGGTCAAAAAGAAATCTAGCCGCAACATATTCAGCATCGTGTTT
GTGTTTTTTGTCTGTTTTGTACCTTACCATATTGCCAGAATCCCCTACACAAAGAGTCAG
ACCGAAGCTCATTACAGCTGCCAGTCAAAAGAAATCTTGCGGTATATGAAAGAATTCACT
CTGCTACTATCTGCTGCAAATGTATGCTTGGACCCTATTATTTATTTCTTTCTATGCCAG
CCGTTTAGGGAAATCTTATGTAAGAAATTGCACATTCCATTAAAAGCTCAGAATGACCTA
GACATTTCCAGAATCAAAAGAGGAAATACAACACTTGAAAGCACAGATACTTTGTGA
Chromosome Location
3
Locus
3q25.1
External Identifiers
ResourceLink
UniProtKB IDQ15391
UniProtKB Entry NameP2Y14_HUMAN
HGNC IDHGNC:16442
General References
  1. Joensuu T, Hamalainen R, Yuan B, Johnson C, Tegelberg S, Gasparini P, Zelante L, Pirvola U, Pakarinen L, Lehesjoki AE, de la Chapelle A, Sankila EM: Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Am J Hum Genet. 2001 Oct;69(4):673-84. Epub 2001 Aug 27. [Article]
  2. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1994;1(1):27-35. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, Zhu Y, McLaughlin MM, Murdock P, McMillan L, Trill J, Swift A, Aiyar N, Taylor P, Vawter L, Naheed S, Szekeres P, Hervieu G, Scott C, Watson JM, Murphy AJ, Duzic E, Klein C, Bergsma DJ, Wilson S, Livi GP: A G protein-coupled receptor for UDP-glucose. J Biol Chem. 2000 Apr 14;275(15):10767-71. [Article]
  5. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01069Promethazineapproved, investigationalunknowninhibitorDetails