The consensus coding sequences of human breast and colorectal cancers.
Article Details
- CitationCopy to clipboard
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
The consensus coding sequences of human breast and colorectal cancers.
Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.
- PubMed ID
- 16959974 [ View in PubMed]
- Abstract
The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of approximately 90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Histidine decarboxylase P19113 Details Nitric oxide synthase, inducible P35228 Details Adenosine receptor A1 P30542 Details Amiloride-sensitive sodium channel subunit beta P51168 Details Coagulation factor V P12259 Details Solute carrier family 12 member 5 Q9H2X9 Details Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Q02809 Details Phospholipid-transporting ATPase ABCA1 O95477 Details Lutropin-choriogonadotropic hormone receptor P22888 Details Retinoic acid receptor gamma P13631 Details Biotin--protein ligase P50747 Details DNA ligase 3 P49916 Details DNA ligase 1 P18858 Details Retinoic acid receptor beta P10826 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 O15239 Details Tryptophan--tRNA ligase, cytoplasmic P23381 Details Retinol-binding protein 3 P10745 Details Nitric oxide synthase 3 P29474 Details Folate receptor beta P14207 Details Vasopressin V2 receptor P30518 Details Voltage-dependent L-type calcium channel subunit beta-1 Q02641 Details Ornithine transcarbamylase, mitochondrial P00480 Details 11-beta-hydroxysteroid dehydrogenase 1 P28845 Details AMP deaminase 1 P23109 Details Adenosine receptor A3 P0DMS8 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 P51970 Details Vascular endothelial growth factor receptor 2 P35968 Details Glutamate receptor ionotropic, NMDA 2D O15399 Details Serine palmitoyltransferase 1 O15269 Details Histamine H1 receptor P35367 Details Gamma-aminobutyric acid receptor subunit alpha-4 P48169 Details Aminoacylase-1 Q03154 Details Amiloride-sensitive sodium channel subunit gamma P51170 Details Alpha-1A adrenergic receptor P35348 Details Argininosuccinate lyase P04424 Details Endothelin-1 receptor P25101 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 O43678 Details Spermine oxidase Q9NWM0 Details Glutamate carboxypeptidase 2 Q04609 Details Cysteine dioxygenase type 1 Q16878 Details (3R)-3-hydroxyacyl-CoA dehydrogenase Q92506 Details Growth hormone-releasing hormone receptor Q02643 Details Acetyl-CoA carboxylase 1 Q13085 Details Serine/threonine-protein kinase B-raf P15056 Details 72 kDa type IV collagenase P08253 Details ATP-sensitive inward rectifier potassium channel 1 P48048 Details Sodium-dependent dopamine transporter Q01959 Details Cytosolic phospholipase A2 P47712 Details Mineralocorticoid receptor P08235 Details 5'-AMP-activated protein kinase catalytic subunit alpha-1 Q13131 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 O95167 Details T-cell surface antigen CD2 P06729 Details Fibroblast growth factor receptor 2 P21802 Details Gamma-aminobutyric acid receptor subunit alpha-6 Q16445 Details Metabotropic glutamate receptor 1 Q13255 Details Glutamate receptor ionotropic, kainate 2 Q13002 Details Glutamate receptor ionotropic, kainate 3 Q13003 Details N-acetylgalactosamine-6-sulfatase P34059 Details Peroxiredoxin-5, mitochondrial P30044 Details Interferon beta P01574 Details Cytosolic 10-formyltetrahydrofolate dehydrogenase O75891 Details Cubilin O60494 Details Low-density lipoprotein receptor-related protein 2 P98164 Details Vitamin K-dependent protein S P07225 Details Insulin-like growth factor-binding protein 3 P17936 Details DNA topoisomerase 1 P11387 Details Long-chain-fatty-acid--CoA ligase 4 O60488 Details ATP-dependent translocase ABCB1 P08183 Details Protein-glutamine gamma-glutamyltransferase 2 P21980 Details Solute carrier organic anion transporter family member 2B1 O94956 Details von Willebrand factor P04275 Details Myeloperoxidase P05164 Details Microtubule-associated protein 2 P11137 Details Carboxypeptidase E P16870 Details Dipeptidase 1 P16444 Details Inhibitor of nuclear factor kappa-B kinase subunit beta O14920 Details Toll-like receptor 9 Q9NR96 Details Fibronectin P02751 Details Fatty acid-binding protein, adipocyte P15090 Details Equilibrative nucleoside transporter 1 Q99808 Details Serum amyloid P-component P02743 Details Isocitrate dehydrogenase [NADP] cytoplasmic O75874 Details Triggering receptor expressed on myeloid cells 1 Q9NP99 Details Sialic acid-binding Ig-like lectin 7 Q9Y286 Details Poly [ADP-ribose] polymerase 1 P09874 Details Serine protease 1 P07477 Details Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 Details TGF-beta receptor type-2 P37173 Details Thromboxane-A synthase P24557 Details Complement C1q subcomponent subunit B P02746 Details Laminin subunit gamma-1 P11047 Details Prolow-density lipoprotein receptor-related protein 1 Q07954 Details Nidogen-1 P14543 Details Bone marrow proteoglycan P13727 Details Neuroendocrine convertase 2 P16519 Details Collagen alpha-1(III) chain P02461 Details Phospholipase D2 O14939 Details Choline transporter-like protein 4 Q53GD3 Details Fatty-acid amide hydrolase 1 O00519 Details Amine oxidase [flavin-containing] A P21397 Details Xanthine dehydrogenase/oxidase P47989 Details Prolyl 3-hydroxylase 2 Q8IVL5 Details Multifunctional protein CAD P27708 Details Excitatory amino acid transporter 5 O00341 Details Glutamate receptor ionotropic, delta-2 O43424 Details Glutamyl aminopeptidase Q07075 Details Diacylglycerol kinase gamma P49619 Details Sodium- and chloride-dependent glycine transporter 2 Q9Y345 Details Protein-arginine deiminase type-3 Q9ULW8 Details Proline dehydrogenase 1, mitochondrial O43272 Details Voltage-dependent L-type calcium channel subunit beta-2 Q08289 Details ATP-binding cassette sub-family B member 5 Q2M3G0 Details Potassium voltage-gated channel subfamily KQT member 5 Q9NR82 Details Proto-oncogene tyrosine-protein kinase receptor Ret P07949 Details Nicotinamide phosphoribosyltransferase P43490 Details E3 ubiquitin-protein ligase UBR4 Q5T4S7 Details Galectin-2 P05162 Details Angiopoietin-1 receptor Q02763 Details Cellular tumor antigen p53 P04637 Details Tubulin beta-2A chain Q13885 Details Platelet-derived growth factor D Q9GZP0 Details Protein kinase C epsilon type Q02156 Details Interferon alpha-2 P01563 Details Tumor necrosis factor receptor superfamily member 9 Q07011 Details 60S ribosome subunit biogenesis protein NIP7 homolog Q9Y221 Details Transmembrane glycoprotein NMB Q14956 Details 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Q96QU6 Details Histone deacetylase 4 P56524 Details Histone deacetylase 7 Q8WUI4 Details UDP-glucuronosyltransferase 1A9 O60656 Details Cytochrome P450 1A1 P04798 Details Receptor-type tyrosine-protein phosphatase S Q13332 Details Guanylate cyclase soluble subunit alpha-2 P33402 Details Gamma-aminobutyric acid receptor subunit pi O00591 Details A-type voltage-gated potassium channel KCND3 Q9UK17 Details Sodium channel regulatory subunit beta-3 Q9NY72 Details Solute carrier organic anion transporter family member 1A2 P46721 Details Solute carrier organic anion transporter family member 1B3 Q9NPD5 Details Phospholipid-transporting ATPase ABCA3 Q99758 Details Mitochondrial potassium channel ATP-binding subunit Q9NUT2 Details Stromelysin-2 P09238 Details Stromelysin-3 P24347 Details Matrix metalloproteinase-15 P51511 Details Chymotrypsin-like elastase family member 1 Q9UNI1 Details Cytochrome b-c1 complex subunit 2, mitochondrial P22695 Details Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial Q16134 Details Proteasome subunit alpha type-2 P25787 Details 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Q16877 Details Pro-cathepsin H P09668 Details GTPase KRas P01116 Details Ephrin type-A receptor 7 Q15375 Details Gelsolin P06396 Details Destrin P60981 Details Mothers against decapentaplegic homolog 2 Q15796 Details Aconitate hydratase, mitochondrial Q99798 Details Hepatocyte nuclear factor 1-alpha P20823 Details Nuclear receptor ROR-alpha P35398 Details GTP-binding protein Rheb Q15382 Details Acetylcholine receptor subunit delta Q07001 Details 5-hydroxytryptamine receptor 5A P47898 Details Potassium voltage-gated channel subfamily A member 5 P22460 Details Potassium voltage-gated channel subfamily A member 10 Q16322 Details Potassium voltage-gated channel subfamily B member 2 Q92953 Details Kelch-like ECH-associated protein 1 Q14145 Details Y+L amino acid transporter 1 Q9UM01 Details 5-hydroxytryptamine receptor 3C Q8WXA8 Details Ribosomal protein S6 kinase alpha-3 P51812 Details Nuclear factor of activated T-cells, cytoplasmic 1 O95644 Details Protein kinase C zeta type Q05513 Details Ras-related C3 botulinum toxin substrate 2 P15153 Details ATP-sensitive inward rectifier potassium channel 15 Q99712 Details 5'-AMP-activated protein kinase catalytic subunit alpha-2 P54646 Details Cyclic AMP-dependent transcription factor ATF-2 P15336 Details Hyaluronan and proteoglycan link protein 1 P10915 Details Histone H1.4 P10412 Details Dihydropyrimidinase-related protein 2 Q16555 Details Programmed cell death protein 6 O75340 Details Hydroxyacid-oxoacid transhydrogenase, mitochondrial Q8IWW8 Details Natural resistance-associated macrophage protein 2 P49281 Details Ran-specific GTPase-activating protein P43487 Details Protein RIC-3 Q7Z5B4 Details Tubulin monoglycylase TTLL3 Q9Y4R7 Details Lymphoid enhancer-binding factor 1 Q9UJU2 Details Tropomyosin alpha-4 chain P67936 Details Apolipoprotein L1 O14791 Details Pregnancy zone protein P20742 Details Small ribosomal subunit protein uS4 P46781 Details Serine/arginine-rich splicing factor 1 Q07955 Details Myosin-9 P35579 Details Dual specificity testis-specific protein kinase 1 Q15569 Details Serine/threonine-protein kinase TNNI3K Q59H18 Details Ephrin type-A receptor 3 P29320 Details Ephrin type-B receptor 6 O15197 Details Serine/threonine-protein kinase SIK3 Q9Y2K2 Details Mitogen-activated protein kinase kinase kinase 6 O95382 Details Myosin light chain kinase 3 Q32MK0 Details Serine/threonine-protein kinase PAK 6 Q9NQU5 Details Serine/threonine-protein kinase D1 Q15139 Details Serine/threonine-protein kinase PRP4 homolog Q13523 Details Serine/threonine-protein kinase Sgk3 Q96BR1 Details POU domain, class 2, transcription factor 1 P14859 Details Dystrophin P11532 Details P2X purinoceptor 7 Q99572 Details P2Y purinoceptor 14 Q15391 Details Voltage-gated delayed rectifier potassium channel KCNH4 Q9UQ05 Details Zinc transporter ZIP12 Q504Y0 Details Apolipoprotein B-100 P04114 Details Diacylglycerol kinase epsilon P52429 Details V-type proton ATPase 21 kDa proteolipid subunit c'' Q99437 Details V-type proton ATPase subunit E 1 P36543 Details Interleukin-6 receptor subunit beta P40189 Details Signal transducer and activator of transcription 1-alpha/beta P42224 Details Adenylate cyclase type 8 P40145 Details