The consensus coding sequences of human breast and colorectal cancers.

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Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE

The consensus coding sequences of human breast and colorectal cancers.

Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.

PubMed ID
16959974 [ View in PubMed
]
Abstract

The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of approximately 90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Histidine decarboxylaseP19113Details
Nitric oxide synthase, inducibleP35228Details
Adenosine receptor A1P30542Details
Amiloride-sensitive sodium channel subunit betaP51168Details
Coagulation factor VP12259Details
Solute carrier family 12 member 5Q9H2X9Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Q02809Details
ATP-binding cassette sub-family A member 1O95477Details
Lutropin-choriogonadotropic hormone receptorP22888Details
Retinoic acid receptor gammaP13631Details
Biotin--protein ligaseP50747Details
DNA ligase 3P49916Details
DNA ligase 1P18858Details
Retinoic acid receptor betaP10826Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1O15239Details
Tryptophan--tRNA ligase, cytoplasmicP23381Details
Retinol-binding protein 3P10745Details
Nitric oxide synthase, endothelialP29474Details
Folate receptor betaP14207Details
Vasopressin V2 receptorP30518Details
Voltage-dependent L-type calcium channel subunit beta-1Q02641Details
Ornithine carbamoyltransferase, mitochondrialP00480Details
Corticosteroid 11-beta-dehydrogenase isozyme 1P28845Details
AMP deaminase 1P23109Details
Adenosine receptor A3P0DMS8Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8P51970Details
Vascular endothelial growth factor receptor 2P35968Details
Glutamate receptor ionotropic, NMDA 2DO15399Details
Serine palmitoyltransferase 1O15269Details
Histamine H1 receptorP35367Details
Gamma-aminobutyric acid receptor subunit alpha-4P48169Details
Aminoacylase-1Q03154Details
Amiloride-sensitive sodium channel subunit gammaP51170Details
Alpha-1A adrenergic receptorP35348Details
Argininosuccinate lyaseP04424Details
Endothelin-1 receptorP25101Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2O43678Details
Spermine oxidaseQ9NWM0Details
Glutamate carboxypeptidase 2Q04609Details
Cysteine dioxygenase type 1Q16878Details
Estradiol 17-beta-dehydrogenase 8Q92506Details
Growth hormone-releasing hormone receptorQ02643Details
Acetyl-CoA carboxylase 1Q13085Details
Serine/threonine-protein kinase B-rafP15056Details
72 kDa type IV collagenaseP08253Details
ATP-sensitive inward rectifier potassium channel 1P48048Details
Sodium-dependent dopamine transporterQ01959Details
Cytosolic phospholipase A2P47712Details
Mineralocorticoid receptorP08235Details
5'-AMP-activated protein kinase catalytic subunit alpha-1Q13131Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3O95167Details
T-cell surface antigen CD2P06729Details
Fibroblast growth factor receptor 2P21802Details
Gamma-aminobutyric acid receptor subunit alpha-6Q16445Details
Metabotropic glutamate receptor 1Q13255Details
Glutamate receptor ionotropic, kainate 2Q13002Details
Glutamate receptor ionotropic, kainate 3Q13003Details
N-acetylgalactosamine-6-sulfataseP34059Details
Peroxiredoxin-5, mitochondrialP30044Details
Interferon betaP01574Details
Cytosolic 10-formyltetrahydrofolate dehydrogenaseO75891Details
CubilinO60494Details
Low-density lipoprotein receptor-related protein 2P98164Details
Vitamin K-dependent protein SP07225Details
Insulin-like growth factor-binding protein 3P17936Details
DNA topoisomerase 1P11387Details
Long-chain-fatty-acid--CoA ligase 4O60488Details
Multidrug resistance protein 1P08183Details
Protein-glutamine gamma-glutamyltransferase 2P21980Details
Solute carrier organic anion transporter family member 2B1O94956Details
von Willebrand factorP04275Details
MyeloperoxidaseP05164Details
Microtubule-associated protein 2P11137Details
Carboxypeptidase EP16870Details
Dipeptidase 1P16444Details
Inhibitor of nuclear factor kappa-B kinase subunit betaO14920Details
Toll-like receptor 9Q9NR96Details
FibronectinP02751Details
Fatty acid-binding protein, adipocyteP15090Details
Equilibrative nucleoside transporter 1Q99808Details
Serum amyloid P-componentP02743Details
Isocitrate dehydrogenase [NADP] cytoplasmicO75874Details
Triggering receptor expressed on myeloid cells 1Q9NP99Details
Sialic acid-binding Ig-like lectin 7Q9Y286Details
Poly [ADP-ribose] polymerase 1P09874Details
Trypsin-1P07477Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialP11310Details
TGF-beta receptor type-2P37173Details
Thromboxane-A synthaseP24557Details
Complement C1q subcomponent subunit BP02746Details
Laminin subunit gamma-1P11047Details
Prolow-density lipoprotein receptor-related protein 1Q07954Details
Nidogen-1P14543Details
Bone marrow proteoglycanP13727Details
Neuroendocrine convertase 2P16519Details
Collagen alpha-1(III) chainP02461Details
Phospholipase D2O14939Details
Choline transporter-like protein 4Q53GD3Details
Fatty-acid amide hydrolase 1O00519Details
Amine oxidase [flavin-containing] AP21397Details
Xanthine dehydrogenase/oxidaseP47989Details
Prolyl 3-hydroxylase 2Q8IVL5Details
CAD proteinP27708Details
Excitatory amino acid transporter 5O00341Details
Glutamate receptor ionotropic, delta-2O43424Details
Glutamyl aminopeptidaseQ07075Details
Diacylglycerol kinase gammaP49619Details
Sodium- and chloride-dependent glycine transporter 2Q9Y345Details
Protein-arginine deiminase type-3Q9ULW8Details
Proline dehydrogenase 1, mitochondrialO43272Details
Voltage-dependent L-type calcium channel subunit beta-2Q08289Details
ATP-binding cassette sub-family B member 5Q2M3G0Details
Potassium voltage-gated channel subfamily KQT member 5Q9NR82Details
Proto-oncogene tyrosine-protein kinase receptor RetP07949Details
Nicotinamide phosphoribosyltransferaseP43490Details
E3 ubiquitin-protein ligase UBR4Q5T4S7Details
Galectin-2P05162Details
Angiopoietin-1 receptorQ02763Details
Cellular tumor antigen p53P04637Details
Tubulin beta-2A chainQ13885Details
Platelet-derived growth factor DQ9GZP0Details
Protein kinase C epsilon typeQ02156Details
Interferon alpha-2P01563Details
Tumor necrosis factor receptor superfamily member 9Q07011Details
60S ribosome subunit biogenesis protein NIP7 homologQ9Y221Details
Transmembrane glycoprotein NMBQ14956Details
1-aminocyclopropane-1-carboxylate synthase-like protein 1Q96QU6Details
Histone deacetylase 4P56524Details
Histone deacetylase 7Q8WUI4Details
UDP-glucuronosyltransferase 1-9O60656Details
Cytochrome P450 1A1P04798Details
Receptor-type tyrosine-protein phosphatase SQ13332Details
Guanylate cyclase soluble subunit alpha-2P33402Details
Gamma-aminobutyric acid receptor subunit piO00591Details
Potassium voltage-gated channel subfamily D member 3Q9UK17Details
Sodium channel subunit beta-3Q9NY72Details
Solute carrier organic anion transporter family member 1A2P46721Details
Solute carrier organic anion transporter family member 1B3Q9NPD5Details
ATP-binding cassette sub-family A member 3Q99758Details
ATP-binding cassette sub-family B member 8, mitochondrialQ9NUT2Details
Stromelysin-2P09238Details
Stromelysin-3P24347Details
Matrix metalloproteinase-15P51511Details
Chymotrypsin-like elastase family member 1Q9UNI1Details
Cytochrome b-c1 complex subunit 2, mitochondrialP22695Details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialQ16134Details
Proteasome subunit alpha type-2P25787Details
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4Q16877Details
Pro-cathepsin HP09668Details
GTPase KRasP01116Details
Ephrin type-A receptor 7Q15375Details
GelsolinP06396Details
DestrinP60981Details
Mothers against decapentaplegic homolog 2Q15796Details
Aconitate hydratase, mitochondrialQ99798Details
Hepatocyte nuclear factor 1-alphaP20823Details
Nuclear receptor ROR-alphaP35398Details
GTP-binding protein RhebQ15382Details
Acetylcholine receptor subunit deltaQ07001Details
5-hydroxytryptamine receptor 5AP47898Details
Potassium voltage-gated channel subfamily A member 5P22460Details
Potassium voltage-gated channel subfamily A member 10Q16322Details
Potassium voltage-gated channel subfamily B member 2Q92953Details
Kelch-like ECH-associated protein 1Q14145Details
Y+L amino acid transporter 1Q9UM01Details
5-hydroxytryptamine receptor 3CQ8WXA8Details
Ribosomal protein S6 kinase alpha-3P51812Details
Nuclear factor of activated T-cells, cytoplasmic 1O95644Details
Protein kinase C zeta typeQ05513Details
Ras-related C3 botulinum toxin substrate 2P15153Details
ATP-sensitive inward rectifier potassium channel 15Q99712Details
5'-AMP-activated protein kinase catalytic subunit alpha-2P54646Details
Cyclic AMP-dependent transcription factor ATF-2P15336Details
Hyaluronan and proteoglycan link protein 1P10915Details
Histone H1.4P10412Details
Dihydropyrimidinase-related protein 2Q16555Details
Programmed cell death protein 6O75340Details
Hydroxyacid-oxoacid transhydrogenase, mitochondrialQ8IWW8Details
Natural resistance-associated macrophage protein 2P49281Details
Ran-specific GTPase-activating proteinP43487Details
Protein RIC-3Q7Z5B4Details
Tubulin monoglycylase TTLL3Q9Y4R7Details
Lymphoid enhancer-binding factor 1Q9UJU2Details
Tropomyosin alpha-4 chainP67936Details
Apolipoprotein L1O14791Details
Pregnancy zone proteinP20742Details
40S ribosomal protein S9P46781Details
Serine/arginine-rich splicing factor 1Q07955Details
Myosin-9P35579Details
Dual specificity testis-specific protein kinase 1Q15569Details
Serine/threonine-protein kinase TNNI3KQ59H18Details
Ephrin type-A receptor 3P29320Details
Ephrin type-B receptor 6O15197Details
Serine/threonine-protein kinase SIK3Q9Y2K2Details
Mitogen-activated protein kinase kinase kinase 6O95382Details
Myosin light chain kinase 3Q32MK0Details
Serine/threonine-protein kinase PAK 6Q9NQU5Details
Serine/threonine-protein kinase D1Q15139Details
Serine/threonine-protein kinase PRP4 homologQ13523Details
Serine/threonine-protein kinase Sgk3Q96BR1Details
POU domain, class 2, transcription factor 1P14859Details
DystrophinP11532Details
P2X purinoceptor 7Q99572Details
P2Y purinoceptor 14Q15391Details
Potassium voltage-gated channel subfamily H member 4Q9UQ05Details
Zinc transporter ZIP12Q504Y0Details
Apolipoprotein B-100P04114Details
Diacylglycerol kinase epsilonP52429Details
V-type proton ATPase 21 kDa proteolipid subunitQ99437Details
V-type proton ATPase subunit E 1P36543Details
Interleukin-6 receptor subunit betaP40189Details
Signal transducer and activator of transcription 1-alpha/betaP42224Details
Adenylate cyclase type 8P40145Details