Ecto-NOX disulfide-thiol exchanger 2
Details
- Name
- Ecto-NOX disulfide-thiol exchanger 2
- Synonyms
- APK1 antigen
- COVA1
- Cytosolic ovarian carcinoma antigen 1
- tNOX
- Tumor-associated hydroquinone oxidase
- Gene Name
- ENOX2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004780|Ecto-NOX disulfide-thiol exchanger 2 MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL PDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPAT RERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALY LSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPS PPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNIS VWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDS LRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEA ELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGI ISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK FCGFEGLKLT
- Number of residues
- 610
- Molecular Weight
- 70081.515
- Theoretical pI
- 5.78
- GO Classification
- Functionsnucleic acid binding / nucleotide binding / protein disulfide oxidoreductase activityProcessescell growth / oxidation-reduction process / regulation of growth / ultradian rhythmComponentscytosol / external side of plasma membrane / extracellular space
- General Function
- Protein disulfide oxidoreductase activity
- Specific Function
- May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
- Pfam Domain Function
- RRM_1 (PF00076)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016790|Ecto-NOX disulfide-thiol exchanger 2 (ENOX2) ATGACACTACCTATGTCTGATCCAACTGCATGGGCCACAGCAATGAATAATCTTGGAATG GCACCGCTGGGAATTGCCGGACAACCAATTTTACCTGACTTTGATCCTGCTCTTGGAATG ATGACTGGAATTCCACCAATAACTCCAATGATGCCTGGTTTGGGAATAGTACCTCCACCA ATTCCTCCAGATATGCCAGTAGTAAAAGAGATCATACACTGTAAAAGCTGCACGCTCTTC CCTCCAAATCCAAATCTCCCACCTCCTGCAACCCGAGAAAGACCACCAGGATGCAAAACA GTATTTGTGGGTGGTCTGCCTGAAAATGGGACAGAGCAAATCATTGTGGAAGTTTTCGAG CAGTGTGGAGAGATCATTGCCATTCGCAAGAGCAAGAAGAACTTCTGCCACATTCGCTTT GCTGAGGAGTACATGGTGGACAAAGCCCTGTATCTGTCTGGTTACCGCATTCGCCTGGGC TCTAGTACTGACAAGAAGGACACAGGCAGACTCCACGTTGATTTCGCACAGGCTCGAGAT GACCTGTATGAGTGGGAGTGTAAACAGCGTATGCTAGCCAGAGAGGAGCGCCATCGTAGA AGAATGGAAGAAGAAAGATTGCGTCCACCATCTCCACCCCCAGTGGTCCACTATTCAGAT CATGAATGCAGCATTGTTGCTGAAAAATTAAAAGATGATTCCAAATTCTCAGAAGCTGTA CAGACCTTGCTTACCTGGATAGAGCGAGGAGAGGTCAACCGTCGTAGCGCCAATAACTTC TACTCCATGATCCAGTCGGCCAACAGCCATGTCCGCCGCCTGGTGAACGAGAAAGCTGCC CATGAGAAAGATATGGAAGAAGCAAAGGAGAAGTTCAAGCAGGCCCTTTCTGGAATTCTC ATTCAATTTGAGCAGATAGTGGCTGTGTACCATTCCGCCTCCAAGCAGAAGGCATGGGAC CACTTCACAAAAGCCCAGCGGAAGAACATCAGCGTGTGGTGCAAACAAGCTGAGGAAATT CGCAACATTCATAATGATGAATTAATGGGAATCAGGCGAGAAGAAGAAATGGAAATGTCT GATGATGAAATAGAAGAAATGACAGAAACAAAAGAAACTGAGGAATCAGCCTTAGTATCA CAGGCAGAAGCTCTGAAGGAAGAAAATGACAGCCTCCGTTGGCAGCTCGATGCCTACCGG AATGAAGTAGAACTGCTCAAGCAAGAACAAGGCAAAGTCCACAGAGAAGATGACCCTAAC AAAGAACAGCAGCTGAAACTCCTGCAACAAGCCCTGCAAGGAATGCAACAGCATCTACTC AAAGTCCAAGAGGAATACAAAAAGAAAGAAGCTGAACTTGAAAAACTCAAAGATGACAAG TTACAGGTGGAAAAAATGTTGGAAAATCTTAAAGAAAAGGAAAGCTGTGCTTCTAGGCTG TGTGCCTCAAACCAGGATAGCGAATACCCTCTTGAGAAGACCATGAACAGCAGTCCTATC AAATCTGAACGTGAAGCACTGCTAGTGGGGATTATCTCCACATTCCTTCATGTTCACCCA TTTGGAGCAAGCATTGAATACATCTGTTCCTACTTGCACCGTCTTGATAATAAGATCTGC ACCAGCGATGTGGAGTGTCTCATGGGTAGACTCCAGCATACCTTCAAGCAGGAAATGACT GGAGTTGGAGCCAGCCTGGAAAAGAGATGGAAATTCTGTGGCTTCGAGGGCTTGAAGCTG ACCTAA
- Chromosome Location
- X
- Locus
- Xq25-q26.2
- External Identifiers
Resource Link UniProtKB ID Q16206 UniProtKB Entry Name ENOX2_HUMAN GenBank Gene ID AF207881 GenAtlas ID ENOX2 HGNC ID HGNC:2259 - General References
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