Calcitonin gene-related peptide type 1 receptor
Details
- Name
- Calcitonin gene-related peptide type 1 receptor
- Synonyms
- Calcitonin receptor-like receptor
- CGRP type 1 receptor
- CGRPR
- Gene Name
- CALCRL
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049732|Calcitonin gene-related peptide type 1 receptor MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
- Number of residues
- 461
- Molecular Weight
- 52928.98
- Theoretical pI
- Not Available
- GO Classification
- Functionsadrenomedullin receptor activity / calcitonin gene-related peptide receptor activity / calcitonin receptor activity / G-protein coupled receptor activity / protein transporter activityProcessesadenylate cyclase-activating G-protein coupled receptor signaling pathway / angiogenesis / calcium ion transport / cAMP biosynthetic process / cell surface receptor signaling pathway / cellular response to sucrose stimulus / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / heart development / negative regulation of inflammatory response / negative regulation of smooth muscle contraction / positive regulation of cAMP biosynthetic process / positive regulation of smooth muscle cell proliferation / protein transport / receptor internalizationComponentsendoplasmic reticulum / endosome / integral component of plasma membrane / lysosome / plasma membrane
- General Function
- Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
- Specific Function
- Adrenomedullin receptor activity
- Pfam Domain Function
- Transmembrane Regions
- 147-166 174-193 214-236 254-273 290-313 337-354 367-388
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0049733|Calcitonin gene-related peptide type 1 receptor (CALCRL) ATGGAGAAAAAGTGTACCCTGTATTTTCTGGTTCTCTTGCCTTTTTTTATGATTCTTGTT ACAGCAGAATTAGAAGAGAGTCCTGAGGACTCAATTCAGTTGGGAGTTACTAGAAATAAA ATCATGACAGCTCAATATGAATGTTACCAAAAGATTATGCAAGACCCCATTCAACAAGCA GAAGGCGTTTACTGCAACAGAACCTGGGATGGATGGCTCTGCTGGAACGATGTTGCAGCA GGAACTGAATCAATGCAGCTCTGCCCTGATTACTTTCAGGACTTTGATCCATCAGAAAAA GTTACAAAGATCTGTGACCAAGATGGAAACTGGTTTAGACATCCAGCAAGCAACAGAACA TGGACAAATTATACCCAGTGTAATGTTAACACCCACGAGAAAGTGAAGACTGCACTAAAT TTGTTTTACCTGACCATAATTGGACACGGATTGTCTATTGCATCACTGCTTATCTCGCTT GGCATATTCTTTTATTTCAAGAGCCTAAGTTGCCAAAGGATTACCTTACACAAAAATCTG TTCTTCTCATTTGTTTGTAACTCTGTTGTAACAATCATTCACCTCACTGCAGTGGCCAAC AACCAGGCCTTAGTAGCCACAAATCCTGTTAGTTGCAAAGTGTCCCAGTTCATTCATCTT TACCTGATGGGCTGTAATTACTTTTGGATGCTCTGTGAAGGCATTTACCTACACACACTC ATTGTGGTGGCCGTGTTTGCAGAGAAGCAACATTTAATGTGGTATTATTTTCTTGGCTGG GGATTTCCACTGATTCCTGCTTGTATACATGCCATTGCTAGAAGCTTATATTACAATGAC AATTGCTGGATCAGTTCTGATACCCATCTCCTCTACATTATCCATGGCCCAATTTGTGCT GCTTTACTGGTGAATCTTTTTTTCTTGTTAAATATTGTACGCGTTCTCATCACCAAGTTA AAAGTTACACACCAAGCGGAATCCAATCTGTACATGAAAGCTGTGAGAGCTACTCTTATC TTGGTGCCATTGCTTGGCATTGAATTTGTGCTGATTCCATGGCGACCTGAAGGAAAGATT GCAGAGGAGGTATATGACTACATCATGCACATCCTTATGCACTTCCAGGGTCTTTTGGTC TCTACCATTTTCTGCTTCTTTAATGGAGAGGTTCAAGCAATTCTGAGAAGAAACTGGAAT CAATACAAAATCCAATTTGGAAACAGCTTTTCCAACTCAGAAGCTCTTCGTAGTGCGTCT TACACAGTGTCAACAATCAGTGATGGTCCAGGTTATAGTCATGACTGTCCTAGTGAACAC TTAAATGGAAAAAGCATCCATGATATTGAAAATGTTCTCTTAAAACCAGAAAATTTATAT AATTGA
- Chromosome Location
- 2
- Locus
- 2q32.1
- External Identifiers
Resource Link UniProtKB ID Q16602 UniProtKB Entry Name CALRL_HUMAN HGNC ID HGNC:16709 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04869 Olcegepant investigational unknown antagonist Details DB12228 Telcagepant investigational unknown Details DB14039 Erenumab approved, investigational unknown Details DB15328 Ubrogepant approved, investigational yes antagonist Details DB12457 Rimegepant approved, investigational yes antagonist Details DB15688 Zavegepant investigational yes antagonist Details DB16098 Atogepant approved, investigational yes antagonist Details