5-methyltetrahydrofolate--homocysteine S-methyltransferase

Details

Name

5-methyltetrahydrofolate--homocysteine S-methyltransferase

Synonyms

• EC 2.1.1.13

Gene Name

Not Available

UniProtKB Entry

Q2RJ67TrEMBL

Organism

Moorella thermoacetica (strain ATCC 39073)

NCBI Taxonomy ID

264732

Amino acid sequence

>lcl|BSEQ0019338|5-methyltetrahydrofolate--homocysteine S-methyltransferase
MPTYEELSQAVFEGDEAQVVELTRSLLSGGAEPLEVINKGLIAGMDRVGVLFKNNEMFVP
EVLMSANAMNAGVEVVKQSQQAFDMPSVGKIVLGTVKGDLHDIGKNLVAMMLESGGFTVY
NLGVDIEPGKFVEAVKKYQPDIVGMSALLTTTMMNMKSTIDALIAAGLRDRVKVIVGGAP
LSQDFADEIGADGYAPDAASATELCRQLLE

Number of residues

210

Molecular Weight

22329.605

Theoretical pI

4.18

GO Classification

Functions

cobalamin binding / cobalt ion binding / methionine synthase activity

Processes

methanogenesis

General Function

Methionine synthase activity

Specific Function

Not Available

Pfam Domain Function

• B12-binding (PF02310)
• B12-binding_2 (PF02607)

Signal Regions

Not Available

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0019339|5-methyltetrahydrofolate--homocysteine S-methyltransferase
ATGCCCACTTATGAAGAACTCTCCCAGGCGGTATTTGAAGGTGATGAAGCACAGGTGGTG
GAATTGACCAGGAGTTTGTTGAGCGGCGGAGCGGAACCCCTGGAAGTGATCAATAAAGGT
CTGATCGCAGGTATGGACCGGGTCGGCGTCCTGTTCAAGAACAACGAGATGTTCGTCCCT
GAGGTCTTAATGTCGGCCAACGCCATGAACGCCGGGGTGGAGGTTGTTAAGCAGAGCCAG
CAAGCCTTTGACATGCCGTCCGTGGGAAAAATCGTACTGGGAACCGTTAAGGGGGACCTG
CACGACATCGGCAAGAACCTGGTGGCCATGATGTTGGAGAGCGGCGGCTTCACGGTTTAC
AACCTGGGGGTGGACATCGAACCGGGTAAATTCGTAGAGGCGGTAAAGAAGTACCAGCCG
GACATCGTGGGCATGTCCGCCCTGTTAACCACCACCATGATGAATATGAAATCAACCATC
GATGCCCTGATCGCCGCCGGGCTGAGGGATCGGGTAAAAGTAATCGTCGGCGGGGCGCCC
CTCAGCCAGGATTTTGCAGATGAGATCGGAGCCGACGGGTATGCTCCGGACGCCGCTTCG
GCCACCGAGCTCTGCAGGCAGCTGCTTGAGTAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q2RJ67
UniProtKB Entry Name	Q2RJ67_MOOTA
GenBank Gene ID	CP000232
PDB ID(s)	1Y80
KEGG ID	mta:Moth_1208
NCBI Gene ID	3832975

General References

1. Pierce E, Xie G, Barabote RD, Saunders E, Han CS, Detter JC, Richardson P, Brettin TS, Das A, Ljungdahl LG, Ragsdale SW: The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum). Environ Microbiol. 2008 Oct;10(10):2550-73. doi: 10.1111/j.1462-2920.2008.01679.x. Epub 2008 Jun 9. [Article]

Associated Data

Bio-Entities

Bio-Entity	Type
5-methyltetrahydrofolate--homocysteine S-methyltransferase (Moorella thermoacetica (strain ATCC 39073))	protein primary

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Vitamin B 12 factor IIIm	experimental	unknown	target		Details