Tyrosine ammonia-lyase
Details
- Name
- Tyrosine ammonia-lyase
- Synonyms
- 4.3.1.23
- Gene Name
- hutH
- UniProtKB Entry
- Q3IWB0Swiss-Prot
- Organism
- Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
- NCBI Taxonomy ID
- 272943
- Amino acid sequence
>lcl|BSEQ0017307|Tyrosine ammonia-lyase MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVY GLTTGFGPLANRLISGENVRTLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASG ASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMVLCLQGRGDFLDRDGTRLDGA EGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAY SLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSD ALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRA TGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
- Number of residues
- 523
- Molecular Weight
- 54913.16
- Theoretical pI
- 7.66
- GO Classification
- Functionsidentical protein binding / tyrosine ammonia-lyase activityProcessesphenylpropanoid biosynthetic process / protein homotetramerization / tyrosine catabolic process
- General Function
- Tyrosine ammonia-lyase activity
- Specific Function
- Catalyzes the non-oxidative deamination of L-tyrosine. Has very low phenylalanine ammonia-lyase activity (in vitro).
- Pfam Domain Function
- Lyase_aromatic (PF00221)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017308|Tyrosine ammonia-lyase (hutH) ATGCTCGCCATGAGCCCCCCGAAGCCGGCCGTCGAGCTGGATCGCCACATCGATCTGGAC CAGGCCCATGCCGTGGCGAGCGGCGGCGCGCGGATTGTCCTTGCCCCTCCGGCGCGCGAC CGGTGCCGTGCGTCCGAAGCGCGGCTCGGCGCTGTCATCCGCGAGGCGCGCCATGTCTAC GGACTGACAACCGGCTTCGGTCCCCTTGCGAACCGCCTGATCTCAGGTGAGAATGTCCGA ACGCTGCAGGCCAATCTTGTCCATCATCTGGCCAGCGGCGTGGGACCGGTGCTTGACTGG ACGACGGCGCGCGCCATGGTTCTGGCGCGTCTGGTGTCGATCGCTCAGGGAGCCTCCGGT GCCAGCGAGGGGACCATCGCTCGCCTGATCGACCTGCTCAATTCCGAGCTCGCTCCGGCC GTTCCCAGCCGCGGCACGGTGGGCGCGTCGGGTGACCTGACACCGCTTGCGCATATGGTG CTCTGCCTCCAGGGCCGGGGAGACTTCCTGGACCGGGACGGGACGCGGCTTGACGGCGCA GAAGGGCTCCGGCGCGGACGGCTGCAACCGCTCGATCTCTCCCATCGCGATGCACTGGCG CTGGTCAACGGGACCTCCGCCATGACCGGGATCGCGCTGGTGAATGCTCACGCCTGCCGC CATCTCGGCAACTGGGCGGTGGCGTTGACGGCCCTGCTTGCGGAATGTCTGAGAGGCCGG ACCGAGGCATGGGCCGCGGCACTGTCCGACCTGCGGCCGCATCCCGGACAGAAGGACGCC GCAGCGAGGCTGCGCGCCCGCGTGGACGGCAGCGCGCGGGTGGTCCGGCACGTCATTGCC GAGCGGAGGCTCGACGCCGGCGATATCGGGACGGAGCCGGAGGCGGGGCAGGATGCCTAC AGCCTGCGCTGCGCTCCGCAGGTTCTCGGGGCGGGCTTCGACACGCTCGCATGGCATGAC CGGGTGCTGACGATCGAGCTGAACGCGGTGACCGACAATCCGGTGTTTCCGCCCGATGGC AGCGTGCCCGCCCTGCACGGGGGCAATTTCATGGGCCAGCATGTGGCGCTGACGTCCGAT GCGCTCGCCACGGCCGTCACCGTTCTGGCGGGCCTTGCGGAGCGCCAGATTGCACGTCTG ACAGATGAAAGGCTGAACCGTGGGCTGCCCCCCTTCCTCCACCGGGGCCCCGCCGGGTTG AATTCCGGCTTCATGGGCGCACAGGTGACGGCGACCGCGCTCCTGGCCGAGATGCGAGCC ACGGGACCTGCCTCGATCCATTCGATCTCCACGAACGCCGCCAATCAGGATGTGGTCTCG CTTGGGACCATCGCCGCGCGCCTCTGCCGCGAGAAGATCGACCGTTGGGCGGAGATCCTT GCGATCCTCGCTCTCTGTCTTGCACAAGCTGCGGAGCTGCGCTGCGGCAGCGGCCTAGAC GGGGTGTCTCCCGCGGGGAAGAAGCTGGTGCAGGCCCTGCGCGAGCAGTTCCCGCCGCTT GAGACGGACCGGCCCCTGGGACAGGAAATTGCCGCGCTTGCTACGCACCTCTTGCAGCAA TCTCCCGTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q3IWB0 UniProtKB Entry Name TALY_RHOS4 GenBank Protein ID 77389407 GenBank Gene ID CP000144 PDB ID(s) 2O6Y, 2O78, 2O7B, 2O7D, 2O7E, 2O7F KEGG ID rsp:RSP_3574 NCBI Gene ID 3722088 - General References
- Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP: Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol. 2006 Dec;13(12):1327-38. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Tyrosine ammonia-lyase (Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 3,4-Dihydroxycinnamic Acid experimental, investigational unknown target Details p-Coumaric acid experimental unknown target Details