Tyrosine ammonia-lyase

Details

Name
Tyrosine ammonia-lyase
Synonyms
  • 4.3.1.23
Gene Name
hutH
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Amino acid sequence
>lcl|BSEQ0017307|Tyrosine ammonia-lyase
MLAMSPPKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVY
GLTTGFGPLANRLISGENVRTLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASG
ASEGTIARLIDLLNSELAPAVPSRGTVGASGDLTPLAHMVLCLQGRGDFLDRDGTRLDGA
EGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGR
TEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAY
SLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSD
ALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRA
TGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLD
GVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
Number of residues
523
Molecular Weight
54913.16
Theoretical pI
7.66
GO Classification
Functions
identical protein binding / tyrosine ammonia-lyase activity
Processes
phenylpropanoid biosynthetic process / protein homotetramerization / tyrosine catabolic process
General Function
Tyrosine ammonia-lyase activity
Specific Function
Catalyzes the non-oxidative deamination of L-tyrosine. Has very low phenylalanine ammonia-lyase activity (in vitro).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017308|Tyrosine ammonia-lyase (hutH)
ATGCTCGCCATGAGCCCCCCGAAGCCGGCCGTCGAGCTGGATCGCCACATCGATCTGGAC
CAGGCCCATGCCGTGGCGAGCGGCGGCGCGCGGATTGTCCTTGCCCCTCCGGCGCGCGAC
CGGTGCCGTGCGTCCGAAGCGCGGCTCGGCGCTGTCATCCGCGAGGCGCGCCATGTCTAC
GGACTGACAACCGGCTTCGGTCCCCTTGCGAACCGCCTGATCTCAGGTGAGAATGTCCGA
ACGCTGCAGGCCAATCTTGTCCATCATCTGGCCAGCGGCGTGGGACCGGTGCTTGACTGG
ACGACGGCGCGCGCCATGGTTCTGGCGCGTCTGGTGTCGATCGCTCAGGGAGCCTCCGGT
GCCAGCGAGGGGACCATCGCTCGCCTGATCGACCTGCTCAATTCCGAGCTCGCTCCGGCC
GTTCCCAGCCGCGGCACGGTGGGCGCGTCGGGTGACCTGACACCGCTTGCGCATATGGTG
CTCTGCCTCCAGGGCCGGGGAGACTTCCTGGACCGGGACGGGACGCGGCTTGACGGCGCA
GAAGGGCTCCGGCGCGGACGGCTGCAACCGCTCGATCTCTCCCATCGCGATGCACTGGCG
CTGGTCAACGGGACCTCCGCCATGACCGGGATCGCGCTGGTGAATGCTCACGCCTGCCGC
CATCTCGGCAACTGGGCGGTGGCGTTGACGGCCCTGCTTGCGGAATGTCTGAGAGGCCGG
ACCGAGGCATGGGCCGCGGCACTGTCCGACCTGCGGCCGCATCCCGGACAGAAGGACGCC
GCAGCGAGGCTGCGCGCCCGCGTGGACGGCAGCGCGCGGGTGGTCCGGCACGTCATTGCC
GAGCGGAGGCTCGACGCCGGCGATATCGGGACGGAGCCGGAGGCGGGGCAGGATGCCTAC
AGCCTGCGCTGCGCTCCGCAGGTTCTCGGGGCGGGCTTCGACACGCTCGCATGGCATGAC
CGGGTGCTGACGATCGAGCTGAACGCGGTGACCGACAATCCGGTGTTTCCGCCCGATGGC
AGCGTGCCCGCCCTGCACGGGGGCAATTTCATGGGCCAGCATGTGGCGCTGACGTCCGAT
GCGCTCGCCACGGCCGTCACCGTTCTGGCGGGCCTTGCGGAGCGCCAGATTGCACGTCTG
ACAGATGAAAGGCTGAACCGTGGGCTGCCCCCCTTCCTCCACCGGGGCCCCGCCGGGTTG
AATTCCGGCTTCATGGGCGCACAGGTGACGGCGACCGCGCTCCTGGCCGAGATGCGAGCC
ACGGGACCTGCCTCGATCCATTCGATCTCCACGAACGCCGCCAATCAGGATGTGGTCTCG
CTTGGGACCATCGCCGCGCGCCTCTGCCGCGAGAAGATCGACCGTTGGGCGGAGATCCTT
GCGATCCTCGCTCTCTGTCTTGCACAAGCTGCGGAGCTGCGCTGCGGCAGCGGCCTAGAC
GGGGTGTCTCCCGCGGGGAAGAAGCTGGTGCAGGCCCTGCGCGAGCAGTTCCCGCCGCTT
GAGACGGACCGGCCCCTGGGACAGGAAATTGCCGCGCTTGCTACGCACCTCTTGCAGCAA
TCTCCCGTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ3IWB0
UniProtKB Entry NameTALY_RHOS4
GenBank Protein ID77389407
GenBank Gene IDCP000144
General References
  1. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP: Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol. 2006 Dec;13(12):1327-38. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB018803,4-Dihydroxycinnamic Acidexperimental, investigationalunknownDetails
DB04066p-Coumaric acidexperimentalunknownDetails