Keratin-associated protein 5-2
Details
- Name
- Keratin-associated protein 5-2
- Synonyms
- KAP5-8
- KAP5.2
- Keratin-associated protein 5-8
- Keratin-associated protein 5.2
- Keratin-associated protein 5.8
- KRTAP5-8
- KRTAP5.2
- KRTAP5.8
- Ultrahigh sulfur keratin-associated protein 5.2
- Gene Name
- KRTAP5-2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013142|Keratin-associated protein 5-2 MGCCGCSRGCGSGCGGCGSSCGGCGSGCGGCGSGRGGCGSGCGGCSSSCGGCGSRCYVPV CCCKPVCSWVPACSCTSCGSCGGSKGGCGSCGGSKGGCGSCGGSKGGCGSCGCSQSSCCK PCCCSSGCGSSCCQSSCCKPCCCQSSCCVPVCCQSSCCKPCCCQSNCCVPVCCQCKI
- Number of residues
- 177
- Molecular Weight
- 16270.68
- Theoretical pI
- Not Available
- GO Classification
- Componentskeratin filament
- General Function
- Not Available
- Specific Function
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
- Pfam Domain Function
- Keratin_B2_2 (PF13885)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0013143|Keratin-associated protein 5-2 (KRTAP5-2) ATGGGCTGCTGTGGCTGCTCCAGAGGCTGTGGCTCCGGCTGTGGGGGCTGTGGCTCCAGC TGTGGGGGTTGTGGCTCTGGCTGTGGGGGCTGTGGCTCCGGCCGTGGGGGCTGTGGCTCT GGCTGTGGGGGCTGCAGCTCCAGCTGTGGGGGATGTGGCTCCAGATGTTATGTGCCTGTC TGCTGCTGCAAGCCCGTGTGCTCCTGGGTGCCAGCCTGTTCCTGCACCAGCTGTGGCTCC TGTGGGGGCTCCAAGGGGGGCTGTGGCTCCTGTGGGGGCTCCAAGGGGGGCTGTGGCTCC TGTGGGGGTTCCAAGGGGGGCTGTGGTTCTTGTGGCTGCTCCCAGTCCAGCTGTTGTAAG CCCTGTTGCTGCTCCTCAGGCTGTGGATCATCCTGCTGCCAGTCCAGCTGCTGCAAGCCC TGCTGCTGCCAGTCCAGCTGCTGTGTCCCCGTGTGCTGCCAGTCCAGCTGCTGCAAGCCC TGTTGCTGCCAGTCCAACTGTTGTGTCCCTGTGTGCTGCCAGTGTAAGATCTGA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q701N4 UniProtKB Entry Name KRA52_HUMAN HGNC ID HGNC:23597 - General References
- Yahagi S, Shibuya K, Obayashi I, Masaki H, Kurata Y, Kudoh J, Shimizu N: Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Biochem Biophys Res Commun. 2004 Jun 4;318(3):655-64. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]