Zinc transporter 7
Details
- Name
- Zinc transporter 7
- Synonyms
- Solute carrier family 30 member 7
- ZnT-7
- Znt-like transporter 2
- ZNT7
- ZNTL2
- Gene Name
- SLC30A7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052333|Zinc transporter 7 MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSN CLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAF FIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFN GALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSHDGPSLKETTGPSRQILQGVFLH ILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPL LENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFT QAGVRQLYVQIDFAAM
- Number of residues
- 376
- Molecular Weight
- 41625.605
- Theoretical pI
- Not Available
- GO Classification
- Functionscation transmembrane transporter activityProcessessequestering of zinc ion / zinc ion transportComponentscell / cytoplasm / cytoplasmic vesicle / Golgi apparatus / integral component of membrane / perinuclear region of cytoplasm / vesicle
- General Function
- Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
- Specific Function
- Cation transmembrane transporter activity
- Pfam Domain Function
- Cation_efflux (PF01545)
- Transmembrane Regions
- 38-58 68-88 103-123 141-161 237-257 263-283
- Cellular Location
- Golgi apparatus
- Gene sequence
>lcl|BSEQ0052334|Zinc transporter 7 (SLC30A7) ATGTTGCCCCTGTCCATCAAAGACGATGAATACAAACCACCCAAGTTCAATTTGTTCGGC AAGATCTCGGGCTGGTTTAGGTCTATACTGTCCGACAAGACTTCCCGGAACCTGTTTTTC TTCCTGTGCCTGAACCTCTCTTTCGCTTTTGTGGAACTACTCTACGGCATCTGGAGCAAC TGCTTAGGCTTGATTTCCGACTCTTTTCACATGTTTTTCGATAGCACTGCCATTTTGGCT GGACTGGCAGCTTCTGTTATTTCAAAATGGAGAGATAATGATGCTTTCTCCTATGGGTAT GTTAGAGCGGAAGTTCTGGCTGGCTTTGTCAATGGCCTATTTTTGATCTTCACTGCTTTT TTTATTTTCTCAGAAGGAGTTGAGAGAGCATTAGCCCCTCCAGATGTCCACCATGAGAGA CTGCTTCTTGTTTCCATTCTTGGGTTTGTGGTAAACCTAATAGGAATATTTGTTTTCAAA CATGGAGGTCATGGACATTCTCATGGCTCTGGCCACGGACACAGTCATTCCCTCTTTAAT GGTGCTCTAGATCAGGCACATGGCCATGTCGATCATTGCCATAGCCATGAAGTGAAACAT GGTGCTGCACATAGCCATGATCATGCTCATGGACATGGACACTTTCATTCTCATGATGGC CCGTCCTTAAAAGAAACAACAGGACCCAGCAGACAGATTTTACAAGGTGTATTTTTACAT ATCCTAGCAGATACACTTGGAAGTATTGGTGTAATTGCTTCTGCCATCATGATGCAAAAT TTTGGTCTGATGATAGCAGATCCTATCTGTTCAATTCTTATAGCCATTCTTATAGTTGTA AGTGTTATTCCTCTTTTAAGAGAATCTGTTGGAATATTAATGCAGAGAACTCCTCCCCTA TTAGAAAATAGTCTGCCTCAGTGCTATCAGAGGGTACAGCAGTTGCAAGGAGTTTACAGT TTACAGGAACAGCACTTCTGGACTTTATGTTCTGACGTTTATGTTGGGACCTTGAAATTA ATAGTAGCACCTGATGCTGATGCTAGGTGGATTTTAAGCCAAACACATAATATTTTTACT CAGGCTGGAGTGAGACAGCTCTACGTACAGATTGACTTTGCAGCCATGTAG
- Chromosome Location
- 1
- Locus
- 1p21.2
- External Identifiers
Resource Link UniProtKB ID Q8NEW0 UniProtKB Entry Name ZNT7_HUMAN HGNC ID HGNC:19306 - General References
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