Zinc transporter 7

Details

Name
Zinc transporter 7
Synonyms
  • Solute carrier family 30 member 7
  • ZnT-7
  • Znt-like transporter 2
  • ZNT7
  • ZNTL2
Gene Name
SLC30A7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052333|Zinc transporter 7
MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSN
CLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAF
FIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFN
GALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSHDGPSLKETTGPSRQILQGVFLH
ILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPL
LENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFT
QAGVRQLYVQIDFAAM
Number of residues
376
Molecular Weight
41625.605
Theoretical pI
Not Available
GO Classification
Functions
cation transmembrane transporter activity
Processes
sequestering of zinc ion / zinc ion transport
Components
cell / cytoplasm / cytoplasmic vesicle / Golgi apparatus / integral component of membrane / perinuclear region of cytoplasm / vesicle
General Function
Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
Specific Function
Cation transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
38-58 68-88 103-123 141-161 237-257 263-283
Cellular Location
Golgi apparatus
Gene sequence
>lcl|BSEQ0052334|Zinc transporter 7 (SLC30A7)
ATGTTGCCCCTGTCCATCAAAGACGATGAATACAAACCACCCAAGTTCAATTTGTTCGGC
AAGATCTCGGGCTGGTTTAGGTCTATACTGTCCGACAAGACTTCCCGGAACCTGTTTTTC
TTCCTGTGCCTGAACCTCTCTTTCGCTTTTGTGGAACTACTCTACGGCATCTGGAGCAAC
TGCTTAGGCTTGATTTCCGACTCTTTTCACATGTTTTTCGATAGCACTGCCATTTTGGCT
GGACTGGCAGCTTCTGTTATTTCAAAATGGAGAGATAATGATGCTTTCTCCTATGGGTAT
GTTAGAGCGGAAGTTCTGGCTGGCTTTGTCAATGGCCTATTTTTGATCTTCACTGCTTTT
TTTATTTTCTCAGAAGGAGTTGAGAGAGCATTAGCCCCTCCAGATGTCCACCATGAGAGA
CTGCTTCTTGTTTCCATTCTTGGGTTTGTGGTAAACCTAATAGGAATATTTGTTTTCAAA
CATGGAGGTCATGGACATTCTCATGGCTCTGGCCACGGACACAGTCATTCCCTCTTTAAT
GGTGCTCTAGATCAGGCACATGGCCATGTCGATCATTGCCATAGCCATGAAGTGAAACAT
GGTGCTGCACATAGCCATGATCATGCTCATGGACATGGACACTTTCATTCTCATGATGGC
CCGTCCTTAAAAGAAACAACAGGACCCAGCAGACAGATTTTACAAGGTGTATTTTTACAT
ATCCTAGCAGATACACTTGGAAGTATTGGTGTAATTGCTTCTGCCATCATGATGCAAAAT
TTTGGTCTGATGATAGCAGATCCTATCTGTTCAATTCTTATAGCCATTCTTATAGTTGTA
AGTGTTATTCCTCTTTTAAGAGAATCTGTTGGAATATTAATGCAGAGAACTCCTCCCCTA
TTAGAAAATAGTCTGCCTCAGTGCTATCAGAGGGTACAGCAGTTGCAAGGAGTTTACAGT
TTACAGGAACAGCACTTCTGGACTTTATGTTCTGACGTTTATGTTGGGACCTTGAAATTA
ATAGTAGCACCTGATGCTGATGCTAGGTGGATTTTAAGCCAAACACATAATATTTTTACT
CAGGCTGGAGTGAGACAGCTCTACGTACAGATTGACTTTGCAGCCATGTAG
Chromosome Location
1
Locus
1p21.2
External Identifiers
ResourceLink
UniProtKB IDQ8NEW0
UniProtKB Entry NameZNT7_HUMAN
HGNC IDHGNC:19306
General References
  1. Kirschke CP, Huang L: ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. J Biol Chem. 2003 Feb 7;278(6):4096-102. doi: 10.1074/jbc.M207644200. Epub 2002 Nov 21. [Article]
  2. Devergnas S, Chimienti F, Naud N, Pennequin A, Coquerel Y, Chantegrel J, Favier A, Seve M: Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Biochem Pharmacol. 2004 Aug 15;68(4):699-709. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  7. Suzuki T, Ishihara K, Migaki H, Ishihara K, Nagao M, Yamaguchi-Iwai Y, Kambe T: Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells. J Biol Chem. 2005 Sep 2;280(35):30956-62. doi: 10.1074/jbc.M506902200. Epub 2005 Jul 1. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14533Zinc chlorideapproved, investigationalunknownsubstrateDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknownsubstrateDetails