Protein spire homolog 2
Details
- Name
- Protein spire homolog 2
- Synonyms
- KIAA1832
- Spir-2
- SPIR2
- Gene Name
- SPIRE2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037273|Protein spire homolog 2 MARAGSCGGAAAGAGRPEPWELSLEEVLKAYEQPLNEEQAWAVCFQGCRGLRGSPGRRLR DTGDLLLRGDGSVGAREPEAAEPATMVVPLASSEAQTVQSLGFAIYRALDWGLDESEERE LSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTFAQAMRLCAARLT DPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETPRAELDSLGHT DWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDG DIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEIKQERRLRPVR GEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPRPRVLLKAPTLAEMEEM NTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPPGGTEPPRPRAGSAHVW RPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAKHLWLEFSHPVESLALTVEE VMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSWPPSCLFCKRAVCTSCS IKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQGPQWQSVEEAFPHIYS HGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLYIPNTRTLDFK
- Number of residues
- 714
- Molecular Weight
- 79669.945
- Theoretical pI
- 7.66
- GO Classification
- Processesactin cytoskeleton organization / actin nucleation / cleavage furrow formation / establishment of meiotic spindle localization / formin-nucleated actin cable assembly / intracellular transport / polar body extrusion after meiotic divisions / protein transport / vesicle-mediated transportComponentscell cortex / cleavage furrow / cytoplasmic vesicle membrane / cytoskeleton / cytosol / perinuclear region of cytoplasm / plasma membrane
- General Function
- Not Available
- Specific Function
- Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
- Pfam Domain Function
- KIND (PF16474)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012894|Protein spire homolog 2 (SPIRE2) ATGGCCCGGGCGGGCAGCTGCGGCGGCGCCGCGGCGGGCGCAGGGCGGCCGGAGCCCTGG GAGCTGTCCCTGGAGGAGGTGCTGAAGGCCTACGAGCAGCCGCTCAACGAGGAGCAGGCG TGGGCCGTGTGCTTCCAGGGCTGCCGCGGGCTGCGGGGCTCGCCGGGCCGGCGCCTGCGG GATACCGGGGACCTCCTGCTGCGCGGGGACGGCTCGGTCGGGGCGCGGGAGCCCGAGGCC GCGGAACCTGCAACCATGGTCGTGCCACTAGCCAGCTCGGAAGCCCAGACCGTGCAGTCC CTCGGCTTCGCCATCTACCGCGCGCTGGACTGGGGGCTGGACGAGAGCGAGGAGCGCGAA CTCAGCCCTCAGCTGGAGCGGCTCATCGACCTCATGGCCAACAACGACAGCGAGGACAGC GGCTGCGGTGCCGCCGATGAGGGCTACGGGGGTCCCGAGGAGGAGGAGGAGGCCGAGGGC GTCCCCCGCAGCGTGCGCACCTTTGCCCAGGCCATGCGGCTGTGCGCGGCGCGGCTGACC GACCCCCGGGGCGCACAGGCGCATTACCAGGCCGTGTGCCGCGCGCTCTTCGTGGAGACG CTGGAGCTGCGGGCCTTCCTGGCCAGGGTCCGGGAGGCCAAGGAGATGCTGCAGAAGCTT CGGGAGGACGAGCCGCATCTGGAGACGCCTCGGGCAGAGCTGGACAGCCTGGGTCACACA GACTGGGCCCGACTGTGGGTTCAGCTCATGCGGGAGCTCCGCCGCGGAGTGAAGCTGAAG AAGGTGCAAGAGCAGGAGTTCAACCCCCTCCCCACCGAGTTCCAGCTCACGCCCTTCGAG ATGCTGATGCAGGACATCCGGGCCCGGAACTACAAGCTGCGCAAGGTCATGGTGGATGGG GACATCCCGCCCCGGGTGAAGAAGGACGCTCACGAGCTCATCCTGGACTTTATCCGCTCA CGGCCTCCACTGAAGCAGGTCTCTGAGAGGCGGCTGCGCCCGTTGCCACCAAAGCAAAGG TCCCTGCATGAGAAGATCCTGGAGGAGATCAAGCAGGAGCGGAGGCTGCGCCCGGTGCGG GGCGAGGGCTGGGCTGCCCGCGGGTTTGGCTCTCTGCCCTGCATCCTCAACGCCTGCTCC GGAGATGCCAAGTCCACCTCCTGCATCAACCTGTCAGTCACAGATGCTGGGGGCAGCGCC CAGCGCCCGCGGCCCCGCGTGCTGCTCAAGGCGCCTACCTTGGCTGAAATGGAAGAGATG AATACATCTGAGGAAGAAGAGTCTCCGTGTGGGGAGGTGACGCTGAAACGGGACCGCTCC TTCTCAGAGCATGACCTGGCCCAGCTCCGAAGTGAGGTGGCCTCTGGCCTGCAGTCGGCC ACCCACCCCCCAGGAGGGACGGAGCCACCACGGCCCCGAGCTGGCAGTGCGCATGTGTGG AGGCCCGGCTCCCGAGACCAGGGTACCTGTCCCGCGAGTGTCTCTGACCCCAGCCACCCC CTACTCAGCAACCGGGGCTCCTCGGGGGACAGACCCGAGGCCTCCATGACCCCCGATGCC AAACACCTGTGGCTGGAGTTCAGCCACCCCGTGGAGAGCCTGGCGCTGACTGTGGAAGAG GTGATGGACGTGCGCCGTGTGCTGGTGAAGGCCGAGATGGAAAAGTTTTTGCAGAACAAG GAGCTCTTCAGCAGTCTGAAGAAGGGGAAGATTTGCTGCTGCTGCCGGGCCAAGTTCCCG CTGTTCTCGTGGCCGCCCAGCTGTCTCTTCTGCAAGAGAGCCGTCTGCACTTCCTGTAGC ATAAAGATGAAGATGCCTTCTAAGAAATTTGGACACATCCCTGTCTACACACTGGGCTTT GAGAGTCCTCAGAGGGTATCAGCTGCCAAAACCGCGCCAATCCAGAGAAGAGACATCTTT CAGTCTCTGCAAGGGCCACAGTGGCAGAGCGTGGAGGAGGCGTTCCCCCACATCTACTCC CACGGCTGTGTCCTGAAGGATGTCTGCAGTGAGTGCACCAGCTTTGTGGCAGACGTGGTG CGTTCCAGCCGCAAGAGCGTGGACGTCCTCAACACTACGCCACGACGCAGTCGCCAGACC CAATCCCTCTACATCCCTAACACCAGGACTCTTGACTTCAAGTGA
- Chromosome Location
- 16
- Locus
- 16q24
- External Identifiers
Resource Link UniProtKB ID Q8WWL2 UniProtKB Entry Name SPIR2_HUMAN GenBank Protein ID 17932848 GenBank Gene ID AJ422077 HGNC ID HGNC:30623 - General References
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- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Pfender S, Kuznetsov V, Pleiser S, Kerkhoff E, Schuh M: Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr Biol. 2011 Jun 7;21(11):955-60. doi: 10.1016/j.cub.2011.04.029. Epub 2011 May 27. [Article]