A quantitative atlas of mitotic phosphorylation.

Article Details

Citation

Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP

A quantitative atlas of mitotic phosphorylation.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.

PubMed ID
18669648 [ View in PubMed
]
Abstract

The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed daughter cells. Protein phosphorylation by cyclin-dependent kinases (CDKs) drives this cycle. To gain further insight into how phosphorylation regulates the cell cycle, we sought to identify proteins whose phosphorylation is cell cycle regulated. Using stable isotope labeling along with a two-step strategy for phosphopeptide enrichment and high mass accuracy mass spectrometry, we examined protein phosphorylation in a human cell line arrested in the G(1) and mitotic phases of the cell cycle. We report the identification of >14,000 different phosphorylation events, more than half of which, to our knowledge, have not been described in the literature, along with relative quantitative data for the majority of these sites. We observed >1,000 proteins with increased phosphorylation in mitosis including many known cell cycle regulators. The majority of sites on regulated phosphopeptides lie in [S/T]P motifs, the minimum required sequence for CDKs, suggesting that many of the proteins may be CDK substrates. Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tyrosine-protein kinase ABL1P00519Details
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialP56181Details
Dehydrogenase/reductase SDR family member 4Q9BTZ2Details
Insulin receptorP06213Details
RAF proto-oncogene serine/threonine-protein kinaseP04049Details
TransketolaseP29401Details
Acetyl-CoA acetyltransferase, mitochondrialP24752Details
Creatine kinase B-typeP12277Details
Pyruvate kinase PKMP14618Details
S-adenosylmethionine decarboxylase proenzymeP17707Details
Solute carrier family 12 member 6Q9UHW9Details
Biotin--protein ligaseP50747Details
NADH-cytochrome b5 reductase 3P00387Details
D-3-phosphoglycerate dehydrogenaseO43175Details
DNA ligase 3P49916Details
Monocarboxylate transporter 7O15403Details
Bifunctional glutamate/proline--tRNA ligaseP07814Details
DNA ligase 1P18858Details
Calcium-transporting ATPase type 2C member 1P98194Details
Large neutral amino acids transporter small subunit 1Q01650Details
Tryptophan--tRNA ligase, cytoplasmicP23381Details
Neutral amino acid transporter B(0)Q15758Details
Adrenodoxin, mitochondrialP10109Details
5'-AMP-activated protein kinase subunit beta-1Q9Y478Details
Cytosolic purine 5'-nucleotidaseP49902Details
Solute carrier family 12 member 7Q9Y666Details
Solute carrier family 12 member 2P55011Details
Alanine--tRNA ligase, cytoplasmicP49588Details
S-adenosylmethionine synthase isoform type-2P31153Details
GMP synthase [glutamine-hydrolyzing]P49915Details
Acetyl-coenzyme A synthetase, cytoplasmicQ9NR19Details
Ferritin heavy chainP02794Details
Retinoic acid receptor RXR-alphaP19793Details
CalmodulinP0DP23Details
Annexin A1P04083Details
RAC-alpha serine/threonine-protein kinaseP31749Details
Serine/threonine-protein kinase A-RafP10398Details
Abelson tyrosine-protein kinase 2P42684Details
cGMP-inhibited 3',5'-cyclic phosphodiesterase AQ14432Details
Histamine H1 receptorP35367Details
Monocarboxylate transporter 4O15427Details
Neutral amino acid transporter AP43007Details
Isoleucine--tRNA ligase, cytoplasmicP41252Details
Receptor tyrosine-protein kinase erbB-2P04626Details
Chromodomain-helicase-DNA-binding protein 1O14646Details
Glyceraldehyde-3-phosphate dehydrogenaseP04406Details
Methionine--tRNA ligase, cytoplasmicP56192Details
DNA polymerase alpha catalytic subunitP09884Details
Cationic amino acid transporter 2P52569Details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialP08559Details
Solute carrier family 12 member 4Q9UP95Details
Asparagine--tRNA ligase, cytoplasmicO43776Details
Choline-phosphate cytidylyltransferase AP49585Details
Acetyl-CoA carboxylase 1Q13085Details
Serine/threonine-protein kinase B-rafP15056Details
Cytosolic phospholipase A2P47712Details
Monocarboxylate transporter 1P53985Details
5'-AMP-activated protein kinase catalytic subunit alpha-1Q13131Details
Retinoic acid-induced protein 3Q8NFJ5Details
Cysteine--tRNA ligase, cytoplasmicP49589Details
Acetyl-CoA carboxylase 2O00763Details
DNA polymerase alpha subunit BQ14181Details
Inosine-5'-monophosphate dehydrogenase 2P12268Details
Pyrroline-5-carboxylate reductase 2Q96C36Details
Biliverdin reductase AP53004Details
DNA topoisomerase 2-alphaP11388Details
Sodium/hydrogen exchanger 1P19634Details
Epidermal growth factor receptorP00533Details
Activated CDC42 kinase 1Q07912Details
5'-AMP-activated protein kinase subunit beta-2O43741Details
Glucocorticoid receptorP04150Details
Tyrosine-protein kinase FynP06241Details
Tyrosine-protein kinase YesP07947Details
Ephrin type-A receptor 2P29317Details
Perilipin-3O60664Details
CTP synthase 1P17812Details
Signal transducer and activator of transcription 5BP51692Details
DNA (cytosine-5)-methyltransferase 1P26358Details
Solute carrier family 2, facilitated glucose transporter member 4P14672Details
CalpastatinP20810Details
Hepatocyte growth factor receptorP08581Details
Growth factor receptor-bound protein 2P62993Details
C-X-C chemokine receptor type 4P61073Details
Mitogen-activated protein kinase 1P28482Details
Cyclic AMP-responsive element-binding protein 1P16220Details
Fatty acid synthaseP49327Details
Apoptosis-inducing factor 1, mitochondrialO95831Details
DNA topoisomerase 1P11387Details
Catenin beta-1P35222Details
Thiopurine S-methyltransferaseP51580Details
Long-chain-fatty-acid--CoA ligase 4O60488Details
CalnexinP27824Details
Rho-associated protein kinase 1Q13464Details
Mitogen-activated protein kinase 14Q16539Details
Multidrug resistance protein 1P08183Details
Mucin-2Q02817Details
Transcription factor AP-1P05412Details
Proton-coupled folate transporterQ96NT5Details
Choline transporter-like protein 1Q8WWI5Details
Canalicular multispecific organic anion transporter 2O15438Details
Mitogen-activated protein kinase 3P27361Details
Glycogen synthase kinase-3 betaP49841Details
Canalicular multispecific organic anion transporter 1Q92887Details
Cyclin-dependent kinase 1P06493Details
Intercellular adhesion molecule 1P05362Details
Nuclear factor NF-kappa-B p105 subunitP19838Details
Glucose-6-phosphate 1-dehydrogenaseP11413Details
Phosphatidylserine synthase 1P48651Details
Ras-related C3 botulinum toxin substrate 1P63000Details
CD44 antigenP16070Details
Excitatory amino acid transporter 1P43003Details
Heat shock protein HSP 90-alphaP07900Details
Protein kinase C alpha typeP17252Details
cAMP-specific 3',5'-cyclic phosphodiesterase 4AP27815Details
Inositol monophosphatase 1P29218Details
Inhibitor of nuclear factor kappa-B kinase subunit betaO14920Details
E3 ubiquitin-protein ligase XIAPP98170Details
EndoplasminP14625Details
RAC-beta serine/threonine-protein kinaseP31751Details
Phosphatidylethanolamine-binding protein 1P30086Details
Multidrug resistance-associated protein 4O15439Details
Glucose-6-phosphate isomeraseP06744Details
Equilibrative nucleoside transporter 1Q99808Details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialP33316Details
cGMP-inhibited 3',5'-cyclic phosphodiesterase BQ13370Details
Thymidine kinase, cytosolicP04183Details
cAMP-specific 3',5'-cyclic phosphodiesterase 4DQ08499Details
MAP kinase-activated protein kinase 2P49137Details
Tubulin alpha-1C chainQ9BQE3Details
Tubulin alpha-4A chainP68366Details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitP36873Details
Methionine aminopeptidase 2P50579Details
DNA repair protein XRCC4Q13426Details
Fructose-bisphosphate aldolase AP04075Details
M-phase inducer phosphatase 2P30305Details
Ras-related protein Rab-9AP51151Details
Poly [ADP-ribose] polymerase 1P09874Details
Dual specificity protein kinase CLK1P49759Details
Kinesin-like protein KIF11P52732Details
Heat shock protein HSP 90-betaP08238Details
Cyclin-dependent kinase 7P50613Details
ADP-ribose pyrophosphatase, mitochondrialQ9BW91Details
Keratin, type II cytoskeletal 8P05787Details
Retinoblastoma-associated proteinP06400Details
Synaptotagmin-like protein 4Q96C24Details
Fibroblast growth factor receptor 3P22607Details
Serpin B6P35237Details
Pyridoxal-dependent decarboxylase domain-containing protein 1Q6P996Details
Molybdenum cofactor sulfuraseQ96EN8Details
Methylmalonic aciduria and homocystinuria type C proteinQ9Y4U1Details
Methionine adenosyltransferase 2 subunit betaQ9NZL9Details
Phospholipase D1Q13393Details
Peptidyl-glycine alpha-amidating monooxygenaseP19021Details
Multifunctional protein ADE2P22234Details
CAD proteinP27708Details
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2O94808Details
Glutamine--tRNA ligaseP47897Details
N-acetyl-D-glucosamine kinaseQ9UJ70Details
Phosphatidylserine synthase 2Q9BVG9Details
Sphingomyelin phosphodiesterase 4Q9NXE4Details
Peptidyl-prolyl cis-trans isomerase GQ13427Details
Histone deacetylase 1Q13547Details
Histone deacetylase 2Q92769Details
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaP49354Details
Phosphatidylinositol 3-kinase regulatory subunit betaO00459Details
DNA-dependent protein kinase catalytic subunitP78527Details
Serine/threonine-protein kinase mTORP42345Details
Nuclear factor NF-kappa-B p100 subunitQ00653Details
Superoxide dismutase [Cu-Zn]P00441Details
NF-kappa-B essential modulatorQ9Y6K9Details
Protein kinase C delta typeQ05655Details
DNA topoisomerase 2-betaQ02880Details
Carbonic anhydrase 9Q16790Details
Ribonucleoside-diphosphate reductase subunit M2P31350Details
Ephrin type-B receptor 4P54760Details
Keratin, type II cytoskeletal 7P08729Details
E3 ubiquitin-protein ligase UBR4Q5T4S7Details
NAD-dependent protein deacetylase sirtuin-1Q96EB6Details
Voltage-dependent anion-selective channel protein 1P21796Details
Voltage-dependent anion-selective channel protein 2P45880Details
Telomerase-binding protein EST1AQ86US8Details
Prostaglandin E synthase 3Q15185Details
GephyrinQ9NQX3Details
U1 small nuclear ribonucleoprotein AP09012Details
Protein S100-A11P31949Details
Deoxycytidine kinaseP27707Details
Focal adhesion kinase 1Q05397Details
Pleckstrin homology domain-containing family A member 1Q9HB21Details
Axin-1O15169Details
Serine/threonine-protein kinase Chk1O14757Details
Aurora kinase BQ96GD4Details
Disintegrin and metalloproteinase domain-containing protein 9Q13443Details
Bcl-2-like protein 2Q92843Details
Bcl2-associated agonist of cell deathQ92934Details
Far upstream element-binding protein 1Q96AE4Details
cAMP-dependent protein kinase type II-alpha regulatory subunitP13861Details
cAMP-dependent protein kinase type I-alpha regulatory subunitP10644Details
High mobility group protein B1P09429Details
Mitogen-activated protein kinase kinase kinase 1Q13233Details
Protein kinase C epsilon typeQ02156Details
Heat shock protein beta-1P04792Details
Centromere-associated protein EQ02224Details
Tumor necrosis factor receptor superfamily member 11AQ9Y6Q6Details
Signal transducer and activator of transcription 3P40763Details
Ribosome-binding protein 1Q9P2E9Details
Microtubule-associated protein 4P27816Details
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2P16615Details
Transmembrane anterior posterior transformation protein 1 homologQ6NXT6Details
Induced myeloid leukemia cell differentiation protein Mcl-1Q07820Details
Casein kinase I isoform epsilonP49674Details
Heat shock factor protein 1Q00613Details
Histone deacetylase 4P56524Details
Histone deacetylase 7Q8WUI4Details
Integrin alpha-VP06756Details
DNA polymerase epsilon subunit 3Q9NRF9Details
Cation-independent mannose-6-phosphate receptorP11717Details
Multidrug resistance-associated protein 5O15440Details
Solute carrier organic anion transporter family member 4A1Q96BD0Details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AO60658Details
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8BO95263Details
Steroid hormone receptor ERR1P11474Details
Nuclear receptor coactivator 2Q15596Details
Serine/threonine-protein kinase PLK1P53350Details
Disintegrin and metalloproteinase domain-containing protein 17P78536Details
Uracil-DNA glycosylaseP13051Details
Mitogen-activated protein kinase 8P45983Details
Dual specificity protein kinase TTKP33981Details
Endothelin-converting enzyme 1P42892Details
Serine/threonine-protein kinase haspinQ8TF76Details
Inner centromere proteinQ9NQS7Details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunitP62136Details
60S ribosomal protein L15P61313Details
60S ribosomal protein L19P84098Details
60S ribosomal protein L23aP62750Details
60S ribosomal protein L3P39023Details
Triosephosphate isomeraseP60174Details
Cytochrome b-c1 complex subunit 6, mitochondrialP07919Details
Protein kinase C iota typeP41743Details
Proteasome subunit alpha type-3P25788Details
Proteasome subunit alpha type-4P25789Details
Proteasome subunit alpha type-5P28066Details
Casein kinase I isoform gamma-3Q9Y6M4Details
STE20-like serine/threonine-protein kinaseQ9H2G2Details
Dual specificity protein kinase CLK3P49761Details
Nuclear receptor coactivator 5Q9HCD5Details
Hydroxymethylglutaryl-CoA synthase, cytoplasmicQ01581Details
Geranylgeranyl transferase type-2 subunit betaP53611Details
Cyclin-dependent kinase 16Q00536Details
Serine/threonine-protein kinase 26Q9P289Details
Peroxisomal acyl-coenzyme A oxidase 1Q15067Details
MKL/myocardin-like protein 1Q969V6Details
Protein spire homolog 2Q8WWL2Details
Cofilin-1P23528Details
Rho-associated protein kinase 2O75116Details
Ribosomal protein S6 kinase alpha-1Q15418Details
Elongation factor 2P13639Details
Alkaline phosphatase, placental typeP05187Details
Tyrosine-protein kinase LynP07948Details
SRSF protein kinase 2P78362Details
Calcium/calmodulin-dependent protein kinase type 1DQ8IU85Details
Glycylpeptide N-tetradecanoyltransferase 1P30419Details
AfadinP55196Details
Interleukin-1 receptor-associated kinase 4Q9NWZ3Details
CREB-binding proteinQ92793Details
Mediator of RNA polymerase II transcription subunit 1Q15648Details
Calcium/calmodulin-dependent protein kinase type II subunit gammaQ13555Details
Mothers against decapentaplegic homolog 2Q15796Details
Protein arginine N-methyltransferase 3O60678Details
Epsin-1Q9Y6I3Details
Phosphoglycerate kinase 1P00558Details
Phosphoglucomutase-1P36871Details
VimentinP08670Details
Uridine 5'-monophosphate synthaseP11172Details
Cytochrome b5 type BO43169Details
Ras-related protein Rab-7aP51149Details
Cation-dependent mannose-6-phosphate receptorP20645Details
Poly(A) polymerase alphaP51003Details
6-pyruvoyl tetrahydrobiopterin synthaseQ03393Details
Inositol 1,4,5-trisphosphate receptor type 1Q14643Details
Unconventional myosin-IeQ12965Details
Ras-related protein Rab-5AP20339Details
Carboxypeptidase DO75976Details
Ubiquitin-like modifier-activating enzyme 1P22314Details
Histone acetyltransferase KAT5Q92993Details
Sorting nexin-3O60493Details
FAD-linked sulfhydryl oxidase ALRP55789Details
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5O60264Details
Uridine-cytidine kinase-like 1Q9NWZ5Details
Spectrin beta chain, non-erythrocytic 1Q01082Details
Spliceosome RNA helicase DDX39BQ13838Details
Ribosomal protein S6 kinase alpha-4O75676Details
Kinesin-like protein KIF2CQ99661Details
Transient receptor potential cation channel subfamily M member 7Q96QT4Details
Hepatocyte growth factor-regulated tyrosine kinase substrateO14964Details
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2Q9UL51Details
Peroxiredoxin-6P30041Details
Sodium bicarbonate cotransporter 3Q9Y6M7Details
Electroneutral sodium bicarbonate exchanger 1Q2Y0W8Details
Myc proto-oncogene proteinP01106Details
Hyaluronan mediated motility receptorO75330Details
Folate transporter 1P41440Details
Sphingosine kinase 1Q9NYA1Details
Proteasome subunit beta type-8P28062Details
Discoidin domain-containing receptor 2Q16832Details
Breakpoint cluster region proteinP11274Details
Dual specificity mitogen-activated protein kinase kinase 2P36507Details
Mitogen-activated protein kinase kinase kinase 2Q9Y2U5Details
LIM domain kinase 1P53667Details
RalA-binding protein 1Q15311Details
5'(3')-deoxyribonucleotidase, cytosolic typeQ8TCD5Details
Transferrin receptor protein 1P02786Details
Ribosomal protein S6 kinase alpha-3P51812Details
Protein kinase C gamma typeP05129Details
Protein kinase C zeta typeQ05513Details
Membrane-associated progesterone receptor component 1O00264Details
5'-AMP-activated protein kinase catalytic subunit alpha-2P54646Details
Inositol 1,4,5-trisphosphate receptor type 2Q14571Details
Inositol 1,4,5-trisphosphate receptor type 3Q14573Details
Cyclic AMP-dependent transcription factor ATF-1P18846Details
Cyclic AMP-dependent transcription factor ATF-2P15336Details
Cyclic AMP-dependent transcription factor ATF-7P17544Details
Complement component 1 Q subcomponent-binding protein, mitochondrialQ07021Details
Intracellular hyaluronan-binding protein 4Q5JVS0Details
Sodium/potassium-transporting ATPase subunit alpha-2P50993Details
Sodium-dependent phosphate transporter 1Q8WUM9Details
Transient receptor potential cation channel subfamily V member 6Q9H1D0Details
Transient receptor potential cation channel subfamily V member 5Q9NQA5Details
Histone H1.4P10412Details
Casein kinase II subunit betaP67870Details
Sterol regulatory element-binding protein 1P36956Details
Mitogen-activated protein kinase kinase kinase MLTQ9NYL2Details
Dihydropyrimidinase-related protein 2Q16555Details
Alpha-enolaseP06733Details
Protein PMLP29590Details
Nucleolar and coiled-body phosphoprotein 1Q14978Details
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Q15750Details
Protein O-GlcNAcaseO60502Details
UtrophinP46939Details
Proprotein convertase subtilisin/kexin type 9Q8NBP7Details
Calsequestrin-2O14958Details
Translationally-controlled tumor proteinP13693Details
Calmodulin-2P0DP24Details
Calmodulin-3P0DP25Details
DNA-3-methyladenine glycosylaseP29372Details
60 kDa heat shock protein, mitochondrialP10809Details
40S ribosomal protein S2P15880Details
Heterogeneous nuclear ribonucleoproteins A2/B1P22626Details
Heterogeneous nuclear ribonucleoprotein HP31943Details
Heterogeneous nuclear ribonucleoprotein H3P31942Details
Heterogeneous nuclear ribonucleoprotein LP14866Details
Splicing factor, proline- and glutamine-richP23246Details
Stress-induced-phosphoprotein 1P31948Details
Eukaryotic translation initiation factor 6P56537Details
Eukaryotic initiation factor 4A-IP60842Details
Hepatoma-derived growth factorP51858Details
Phosphoglycerate mutase 1P18669Details
Ran-specific GTPase-activating proteinP43487Details
HuntingtinP42858Details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Q8N1G2Details
Neural cell adhesion molecule L1P32004Details
Cyclin-dependent kinase inhibitor 1P38936Details
Eukaryotic translation initiation factor 3 subunit FO00303Details
Heterogeneous nuclear ribonucleoprotein KP61978Details
Heat shock 70 kDa protein 4P34932Details
Heat shock protein 105 kDaQ92598Details
Nuclear migration protein nudCQ9Y266Details
Splicing factor 3A subunit 3Q12874Details
Tumor protein D54O43399Details
Tropomyosin alpha-1 chainP09493Details
Tropomyosin alpha-3 chainP06753Details
Ubiquitin carboxyl-terminal hydrolase 14P54578Details
14-3-3 protein thetaP27348Details
Alpha-2-HS-glycoproteinP02765Details
Chromobox protein homolog 5P45973Details
Keratin, type I cytoskeletal 9P35527Details
DesmoplakinP15924Details
Inter-alpha-trypsin inhibitor heavy chain H1P19827Details
KAT8 regulatory NSL complex subunit 3Q9P2N6Details
Far upstream element-binding protein 2Q92945Details
Cysteine and glycine-rich protein 1P21291Details
Filamin-AP21333Details
Heterogeneous nuclear ribonucleoprotein D0Q14103Details
Heterochromatin protein 1-binding protein 3Q5SSJ5Details
Ras GTPase-activating-like protein IQGAP1P46940Details
NucleophosminP06748Details
60S ribosomal protein L14P50914Details
60S ribosomal protein L18Q07020Details
60S ribosomal protein L4P36578Details
40S ribosomal protein S17P08708Details
40S ribosomal protein S6P62753Details
40S ribosomal protein S8P62241Details
Splicing factor 1Q15637Details
Small nuclear ribonucleoprotein Sm D2P62316Details
Transgelin-2P37802Details
ZyxinQ15942Details
Serine/arginine-rich splicing factor 1Q07955Details
Survival motor neuron proteinB4DP61Details
Myosin-9P35579Details
Probable ATP-dependent RNA helicase DDX5P17844Details
Splicing factor 3B subunit 1O75533Details
Elongation of very long chain fatty acids protein 5Q9NYP7Details
Serine/threonine-protein kinase 3Q13188Details
Serine/threonine-protein kinase 38Q15208Details
Serine/threonine-protein kinase TAO1Q7L7X3Details
Serine/threonine-protein kinase TAO3Q9H2K8Details
Serine/threonine-protein kinase tousled-like 1Q9UKI8Details
Serine/threonine-protein kinase tousled-like 2Q86UE8Details
TRAF2 and NCK-interacting protein kinaseQ9UKE5Details
Non-receptor tyrosine-protein kinase TNK1Q13470Details
Serine/threonine-protein kinase ULK1O75385Details
AP2-associated protein kinase 1Q2M2I8Details
Calcium/calmodulin-dependent protein kinase kinase 1Q8N5S9Details
Calcium/calmodulin-dependent protein kinase kinase 2Q96RR4Details
Citron Rho-interacting kinaseO14578Details
Dual specificity protein kinase CLK2P49760Details
Dual specificity protein kinase CLK4Q9HAZ1Details
Death-associated protein kinase 2Q9UIK4Details
Interferon-induced, double-stranded RNA-activated protein kinaseP19525Details
eIF-2-alpha kinase GCN2Q9P2K8Details
Cyclin-G-associated kinaseO14976Details
Glycogen synthase kinase-3 alphaP49840Details
Interleukin-1 receptor-associated kinase 1P51617Details
Serine/threonine-protein kinase SIK3Q9Y2K2Details
Serine/threonine-protein kinase LATS1O95835Details
LIM domain kinase 2P53671Details
Dual specificity mitogen-activated protein kinase kinase 6P52564Details
Mitogen-activated protein kinase kinase kinase 11Q16584Details
Mitogen-activated protein kinase kinase kinase 6O95382Details
Mitogen-activated protein kinase kinase kinase kinase 2Q12851Details
Mitogen-activated protein kinase kinase kinase kinase 4O95819Details
Mitogen-activated protein kinase 4P31152Details
Mitogen-activated protein kinase 7Q13164Details
MAP kinase-activated protein kinase 5Q8IW41Details
Serine/threonine-protein kinase MARK1Q9P0L2Details
Serine/threonine-protein kinase MARK2Q7KZI7Details
MAP/microtubule affinity-regulating kinase 3P27448Details
CLIP-associating protein 1Q7Z460Details
Megakaryocyte-associated tyrosine-protein kinaseP42679Details
Maternal embryonic leucine zipper kinaseQ14680Details
Misshapen-like kinase 1Q8N4C8Details
MAP kinase-interacting serine/threonine-protein kinase 1Q9BUB5Details
MAP kinase-interacting serine/threonine-protein kinase 2Q9HBH9Details
Serine/threonine-protein kinase Nek1Q96PY6Details
Serine/threonine-protein kinase Nek4P51957Details
Serine/threonine-protein kinase Nek9Q8TD19Details
Serine/threonine-protein kinase OSR1O95747Details
Serine/threonine-protein kinase PAK 1Q13153Details
Serine/threonine-protein kinase PAK 2Q13177Details
Serine/threonine-protein kinase PAK 4O96013Details
Cyclin-dependent kinase 17Q00537Details
Phosphatidylinositol 4-kinase betaQ9UBF8Details
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaO00750Details
Phosphatidylinositol 5-phosphate 4-kinase type-2 betaP78356Details
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseQ99640Details
Serine/threonine-protein kinase N1Q16512Details
Serine/threonine-protein kinase N2Q16513Details
Serine/threonine-protein kinase PLK4O00444Details
Serine/threonine-protein kinase PRP4 homologQ13523Details
Serine/threonine-protein kinase RIO1Q9BRS2Details
Serine/threonine-protein kinase RIO2Q9BVS4Details
Serine/threonine-protein kinase RIO3O14730Details
Receptor-interacting serine/threonine-protein kinase 1Q13546Details
Receptor-interacting serine/threonine-protein kinase 2O43353Details
Serine/threonine-protein kinase SIK2Q9H0K1Details
Serine/threonine-protein kinase 10O94804Details
Serine/threonine-protein kinase 17AQ9UEE5Details
Histone-lysine N-methyltransferase EZH2Q15910Details
Phospholipid transfer proteinP55058Details
Exportin-1O14980Details
POU domain, class 2, transcription factor 1P14859Details
Mitogen-activated protein kinase 6Q16659Details
NAD-dependent protein deacetylase sirtuin-2Q8IXJ6Details
DystrophinP11532Details
Solute carrier family 43 member 3Q8NBI5Details
Peroxisome proliferator-activated receptor gamma coactivator 1-betaQ86YN6Details
Cytochrome b reductase 1Q53TN4Details
ATP-citrate synthaseP53396Details
Very long-chain acyl-CoA synthetaseO14975Details
Sodium-coupled neutral amino acid transporter 1Q9H2H9Details
Sodium-coupled neutral amino acid transporter 2Q96QD8Details
DNA (cytosine-5)-methyltransferase 3AQ9Y6K1Details
Zinc transporter ZIP6Q13433Details
Zinc transporter 1Q9Y6M5Details
Zinc transporter ZIP3Q9BRY0Details
Zinc transporter 6Q6NXT4Details
Tyrosine-protein phosphatase non-receptor type 12Q05209Details
V-type proton ATPase 116 kDa subunit a isoform 4Q9HBG4Details
V-type proton ATPase 116 kDa subunit a isoform 2Q9Y487Details
Caspase-4P49662Details
Plasma membrane calcium-transporting ATPase 1P20020Details
Plasma membrane calcium-transporting ATPase 2Q01814Details
Caspase-9P55211Details
Calcium-transporting ATPase type 2C member 2O75185Details
Interleukin-6 receptor subunit betaP40189Details
Sphingosine kinase 2Q9NRA0Details
Leucyl-cystinyl aminopeptidaseQ9UIQ6Details
Cell surface hyaluronidaseQ9UHN6Details
Molybdopterin synthase catalytic subunitO96007Details
Receptor protein-tyrosine kinaseQ504U8Details
3-ketoacyl-CoA thiolase, mitochondrialP42765Details
Serine/threonine-protein kinase ATRQ13535Details
P-selectin glycoprotein ligand 1Q14242Details
Microphthalmia-associated transcription factorO75030Details
Eukaryotic translation initiation factor 4E-binding protein 1Q13541Details
Lysine-specific histone demethylase 1AO60341Details
Signal transducer and activator of transcription 1-alpha/betaP42224Details
Proliferation marker protein Ki-67P46013Details
G1/S-specific cyclin-D3P30281Details
Histone acetyltransferase p300Q09472Details
ELAV-like protein 1Q15717Details
Dual specificity mitogen-activated protein kinase kinase 4P45985Details
cAMP-dependent protein kinase type I-beta regulatory subunitP31321Details
CD276 antigenQ5ZPR3Details
Mucin-3AQ02505Details
Adenylate cyclase type 8P40145Details
Adenylate cyclase type 6O43306Details
Adenylate cyclase type 9O60503Details