Aquaporin-3
Details
- Name
- Aquaporin-3
- Synonyms
- AQP-3
- Aquaglyceroporin-3
- Gene Name
- AQP3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052020|Aquaporin-3 MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVF GLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVD PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQ HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
- Number of residues
- 292
- Molecular Weight
- 31543.605
- Theoretical pI
- Not Available
- GO Classification
- Functionsglycerol channel activity / transporter activity / urea transmembrane transporter activity / water channel activityProcessescellular response to hypoxia / cellular response to oxygen-glucose deprivation / excretion / odontogenesis / positive regulation of immune system process / regulation of keratinocyte differentiation / renal water absorption / renal water homeostasis / response to calcium ion / response to retinoic acid / response to vitamin D / water transportComponentsbasolateral plasma membrane / cell-cell junction / cytoplasm / integral component of membrane / nucleus / plasma membrane
- General Function
- Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
- Specific Function
- Glycerol channel activity
- Pfam Domain Function
- MIP (PF00230)
- Transmembrane Regions
- 29-49 54-74 110-130 158-178 189-209 245-265
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0052021|Aquaporin-3 (AQP3) ATGGGTCGACAGAAGGAGCTGGTGTCCCGCTGCGGGGAGATGCTCCACATCCGCTACCGG CTGCTCCGACAGGCGCTGGCCGAGTGCCTGGGGACCCTCATCCTGGTGATGTTTGGCTGT GGCTCCGTGGCCCAGGTTGTGCTCAGCCGGGGCACCCACGGTGGTTTCCTCACCATCAAC CTGGCCTTTGGCTTTGCTGTCACTCTGGGCATCCTCATCGCTGGCCAGGTCTCTGGGGCC CACCTGAACCCTGCCGTGACCTTTGCCATGTGCTTCCTGGCTCGTGAGCCCTGGATCAAG CTGCCCATCTACACCCTGGCACAGACGCTGGGAGCCTTCTTGGGTGCTGGAATAGTTTTT GGGCTGTATTATGATGCAATCTGGCACTTCGCCGACAACCAGCTTTTTGTTTCGGGCCCC AATGGCACAGCCGGCATCTTTGCTACCTACCCCTCTGGACACTTGGATATGATCAATGGC TTCTTTGACCAGTTCATAGGCACAGCCTCCCTTATCGTGTGTGTGCTGGCCATTGTTGAC CCCTACAACAACCCCGTCCCCCGAGGCCTGGAGGCCTTCACCGTGGGCCTGGTGGTCCTG GTCATTGGCACCTCCATGGGCTTCAACTCCGGCTATGCCGTCAACCCTGCCCGGGACTTT GGCCCCCGCCTTTTTACAGCCCTTGCGGGCTGGGGCTCTGCAGTCTTCACGACCGGCCAG CATTGGTGGTGGGTGCCCATCGTGTCCCCACTCCTGGGCTCCATTGCGGGTGTCTTCGTG TACCAGCTGATGATCGGCTGCCACCTGGAGCAGCCCCCACCCTCCAACGAGGAAGAGAAT GTGAAGCTGGCCCATGTGAAGCACAAGGAGCAGATCTGA
- Chromosome Location
- 9
- Locus
- 9p13.3
- External Identifiers
Resource Link UniProtKB ID Q92482 UniProtKB Entry Name AQP3_HUMAN HGNC ID HGNC:636 - General References
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