Zinc transporter 3

Details

Name
Zinc transporter 3
Synonyms
  • Solute carrier family 30 member 3
  • ZnT-3
  • ZNT3
Gene Name
SLC30A3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052353|Zinc transporter 3
MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPL
PPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSL
FSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAM
LLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVL
GDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNV
GFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRF
GFSSCTLQVEQYQPEMAQCLRCQEPPQA
Number of residues
388
Molecular Weight
41944.895
Theoretical pI
Not Available
GO Classification
Functions
ATPase-coupled zinc transmembrane transporter activity / zinc ion transmembrane transporter activity
Processes
positive regulation of transport / regulation of sequestering of zinc ion / response to zinc ion / zinc ion import into synaptic vesicle / zinc ion transmembrane transport
Components
cell junction / cytoplasm / endosome / glutamatergic synapse / hippocampal mossy fiber to CA3 synapse / integral component of plasma membrane / integral component of synaptic vesicle membrane / late endosome / late endosome membrane / lysosomal membrane / membrane / neuron projection / plasma membrane / synaptic vesicle
General Function
Involved in accumulation of zinc in synaptic vesicles.
Specific Function
Atpase-coupled zinc transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
76-96 106-126 146-166 178-198 236-256 265-285
Cellular Location
Cytoplasmic vesicle
Gene sequence
>lcl|BSEQ0052354|Zinc transporter 3 (SLC30A3)
ATGGAGCCCTCTCCAGCCGCTGGGGGCTTGGAGACCACTCGCCTGGTGAGCCCCCGGGAC
CGCGGTGGCGCCGGAGGCAGCCTGCGTTTGAAGAGTCTCTTCACAGAGCCCTCAGAGCCC
CTCCCTGAGGAGTCCAAACCTGTGGAGATGCCCTTCCACCACTGCCACAGGGACCCCCTT
CCGCCGCCGGGCCTTACCCCTGAGAGGCTGCATGCACGGAGGCAGCTATATGCTGCCTGT
GCCGTTTGCTTTGTCTTCATGGCTGGGGAGGTGGTCGGCGGGTATCTGGCACACAGCCTG
GCCATCATGACCGATGCAGCCCACTTGCTGGCGGATGTGGGCAGCATGATGGGCAGCCTC
TTCTCCCTCTGGCTCTCCACCCGTCCAGCCACCCGCACCATGACCTTTGGCTGGCACCGT
TCAGAGACTCTGGGGGCTTTGGCCTCTGTGGTCTCCCTCTGGATGGTCACTGGCATCCTC
CTGTACCTGGCCTTCGTCCGCCTGCTGCACAGCGACTACCACATCGAGGGGGGTGCCATG
CTGCTGACCGCCAGCATCGCAGTCTGTGCCAACCTGTTAATGGCCTTTGTGCTGCACCAG
GCTGGGCCCCCCCACAGCCACGGGTCTAGGGGAGCAGAGTATGCACCGCTGGAGGAGGGG
CCTGAAGAGCCCCTGCCCCTGGGGAACACCAGCGTCCGGGCGGCATTTGTGCACGTGCTG
GGGGACCTCCTGCAGAGCTTTGGGGTACTGGCTGCCTCCATCCTCATCTACTTCAAGCCT
CAATACAAGGCAGCCGACCCCATCAGCACCTTCCTCTTCTCCATCTGTGCCCTTGGATCC
ACCGCTCCCACCCTCCGAGACGTTCTTCGAATCCTCATGGAAGGTACCCCCCGCAATGTG
GGGTTCGAACCTGTGCGGGATACGCTGTTGTCGGTGCCAGGAGTCCGGGCAACCCATGAG
CTGCACCTGTGGGCCCTTACGCTCACTTACCATGTTGCCTCTGCACACCTGGCCATCGAC
TCCACCGCTGACCCTGAAGCCGTCCTGGCTGAAGCCTCATCCCGGCTCTACTCCCGGTTT
GGATTCTCCAGCTGCACCCTGCAGGTCGAGCAGTATCAGCCGGAGATGGCCCAGTGCCTG
CGCTGCCAGGAACCCCCCCAAGCCTGA
Chromosome Location
2
Locus
2p23.3
External Identifiers
ResourceLink
UniProtKB IDQ99726
UniProtKB Entry NameZNT3_HUMAN
HGNC IDHGNC:11014
General References
  1. Palmiter RD, Cole TB, Quaife CJ, Findley SD: ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14934-9. doi: 10.1073/pnas.93.25.14934. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Falcon-Perez JM, Dell'Angelica EC: Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007 Apr 15;313(7):1473-83. doi: 10.1016/j.yexcr.2007.02.006. Epub 2007 Feb 15. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14533Zinc chlorideapproved, investigationalunknownsubstrateDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknownsubstrateDetails