Desvancosaminyl-vancomycin vancosaminetransferase
Details
- Name
- Desvancosaminyl-vancomycin vancosaminetransferase
- Synonyms
- 2.4.1.322
- Desvancosamine-vancomycin TDP-vancosaminyltransferase
- Glycosyltransferase GtfD
- Gene Name
- gtfD
- UniProtKB Entry
- Q9AFC7Swiss-Prot
- Organism
- Amycolatopsis orientalis
- NCBI Taxonomy ID
- 31958
- Amino acid sequence
>lcl|BSEQ0012323|Desvancosaminyl-vancomycin vancosaminetransferase MRVLLSVCGTRGDVEIGVALADRLKALGVQTRMCAPPAAEERLAEVGVPHVPVGLPQHMM LQEGMPPPPPEEEQRLAAMTVEMQFDAVPGAAEGCAAVVAVGDLAAATGVRSVAEKLGLP FFYSVPSPVYLASPHLPPAYDEPTTPGVTDIRVLWEERAARFADRYGPTLNRRRAEIGLP PVEDVFGYGHGERPCWPADPVLAPLQPDVDAVQTGAWLLSDERPLPPELEAFLAAGSPPV HIGFGSSSGRGIADAAKVAVEAIRAQGRRVILSRGWTELVLPDDRDDCFAIDEVNFQALF RRVAAVIHHGSAGTEHVATRAGVPQLVIPRNTDQPYFAGRVAALGIGVAHDGPTPTFESL SAALTTVLAPETRARAEAVAGMVLTDGAAAAADLVLAAVGREKPAVPA
- Number of residues
- 408
- Molecular Weight
- 42880.545
- Theoretical pI
- 4.8
- GO Classification
- Functionstransferase activity, transferring hexosyl groupsProcesseslipid glycosylation / vancomycin biosynthetic process
- General Function
- Catalyzes the attachment of L-vancosamine to a monoglucosylated heptapeptide intermediate during the final stage of glycopeptide antibiotic vancomycin biosynthesis.
- Specific Function
- enzyme binding
- Pfam Domain Function
- Glyco_transf_28 (PF03033)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006478|1227 bp ATGCGTGTGTTGTTGTCGGTGTGCGGAACCCGCGGGGACGTCGAAATCGGGGTGGCGCTG GCGGACCGATTGAAGGCGCTCGGCGTCCAGACACGGATGTGCGCGCCGCCCGCCGCCGAG GAGCGGCTGGCGGAGGTCGGGGTGCCGCATGTGCCGGTCGGCCTGCCGCAGCACATGATG TTGCAGGAGGGCATGCCGCCGCCACCGCCCGAAGAGGAACAGCGGCTGGCGGCCATGACG GTCGAGATGCAGTTCGACGCCGTCCCCGGGGCCGCCGAAGGGTGTGCCGCGGTGGTGGCG GTCGGCGATCTGGCCGCCGCGACCGGTGTCCGGTCGGTGGCCGAGAAACTGGGCCTGCCC TTCTTCTATTCCGTCCCCAGTCCGGTCTATCTGGCGTCCCCGCACCTTCCGCCGGCTTAC GACGAGCCGACCACGCCGGGCGTGACCGACATCCGGGTGCTGTGGGAGGAGCGGGCCGCC CGGTTCGCCGACCGGTACGGGCCCACGCTCAACCGTCGCCGGGCCGAGATCGGCCTGCCG CCGGTGGAGGACGTCTTCGGCTACGGCCACGGTGAGCGGCCCTGCTGGCCGGCGGACCCG GTACTGGCGCCCCTGCAGCCGGACGTCGACGCGGTGCAGACCGGTGCGTGGCTCCTGTCC GACGAGCGGCCGCTTCCCCCGGAGCTGGAAGCGTTCCTGGCCGCCGGGTCACCGCCGGTG CACATCGGTTTCGGCAGCTCGTCCGGCCGCGGGATCGCCGACGCCGCGAAGGTGGCCGTC GAGGCGATCCGGGCCCAAGGCCGGCGGGTGATCCTCTCGCGGGGGTGGACCGAGCTGGTC CTGCCCGACGACCGTGACGACTGTTTCGCCATCGACGAGGTGAACTTCCAGGCGCTGTTC CGCCGGGTGGCCGCCGTCATCCACCACGGCAGCGCGGGTACGGAGCACGTGGCCACGCGG GCCGGCGTCCCCCAGCTCGTGATCCCCCGGAACACGGACCAGCCGTACTTCGCCGGGCGG GTGGCCGCGCTGGGGATCGGTGTGGCGCATGACGGCCCGACGCCGACCTTCGAGTCCCTT TCGGCCGCGCTCACCACGGTGCTCGCGCCGGAGACGCGGGCGCGGGCGGAGGCCGTGGCG GGCATGGTCCTCACCGACGGGGCGGCGGCGGCCGCGGATCTGGTGCTCGCCGCGGTCGGC CGGGAGAAGCCCGCCGTTCCCGCGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9AFC7 UniProtKB Entry Name GTFD_AMYOR GenBank Gene ID AF351621 PDB ID(s) 1RRV - General References
- Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT: Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry. 2001 Apr 17;40(15):4745-55. [Article]
- Mulichak AM, Lu W, Losey HC, Walsh CT, Garavito RM: Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry. 2004 May 11;43(18):5170-80. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Desvancosaminyl-vancomycin vancosaminetransferase (Amycolatopsis orientalis) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Desvancosaminyl vancomycin experimental unknown target Details