Iota-carrageenase

Details

Name
Iota-carrageenase
Synonyms
  • 3.2.1.157
Gene Name
cgiA
UniProtKB Entry
Q9F5I8Swiss-Prot
Organism
Alteromonas fortis
NCBI Taxonomy ID
116059
Amino acid sequence
>lcl|BSEQ0011891|Iota-carrageenase
MRLYFRKLWLTNLFLGGALASSAAIGAVSPKTYKDADFYVAPTQQDVNYDLVDDFGANGN
DTSDDSNALQRAINAISRKPNGGTLLIPNGTYHFLGIQMKSNVHIRVESDVIIKPTWNGD
GKNHRLFEVGVNNIVRNFSFQGLGNGFLVDFKDSRDKNLAVFKLGDVRNYKISNFTIDDN
KTIFASILVDVTERNGRLHWSRNGIIERIKQNNALFGYGLIQTYGADNILFRNLHSEGGI
ALRMETDNLLMKNYKQGGIRNIFADNIRCSKGLAAVMFGPHFMKNGDVQVTNVSSVSCGS
AVRSDSGFVELFSPTDEVHTRQSWKQAVESKLGRGCAQTPYARGNGGTRWAARVTQKDAC
LDKAKLEYGIEPGSFGTVKVFDVTARFGYNADLKQDQLDYFSTSNPMCKRVCLPTKEQWS
KQGQIYIGPSLAAVIDTTPETSKYDYDVKTFNVKRINFPVNSHKTIDTNTESSRVCNYYG
MSECSSSRWER
Number of residues
491
Molecular Weight
54794.33
Theoretical pI
9.17
GO Classification
Functions
iota-carrageenase activity
Processes
cell wall organization / polysaccharide catabolic process
Components
extracellular space
General Function
Hydrolyzes iota-carrageenans, sulfated 1,3-alpha-1,4-beta galactans from red algal cell walls, with an inversion of anomeric configuration. Also active against hybrid iota-/nu-carrageenan, not active against kappa- or lambda-carrageenans.
Specific Function
iota-carrageenase activity
Pfam Domain Function
Signal Regions
1-23
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0005237|1476 bp
ATGCGCTTATATTTTAGAAAGTTGTGGTTAACAAATTTATTTTTAGGCGGAGCACTGGCC
TCTTCAGCTGCGATAGGGGCTGTCTCCCCCAAGACTTATAAGGACGCAGATTTTTATGTT
GCCCCTACTCAACAAGATGTTAACTATGATTTAGTTGATGATTTTGGCGCTAATGGAAAC
GACACTAGTGATGACAGTAATGCTTTACAAAGAGCAATTAATGCTATTAGTAGAAAACCG
AATGGGGGCACTTTACTAATACCGAATGGAACTTACCATTTCCTCGGCATACAGATGAAG
TCGAACGTACACATCCGTGTTGAGAGTGACGTGATAATCAAGCCAACGTGGAATGGGGAT
GGCAAAAACCACCGACTATTTGAAGTTGGCGTAAACAATATTGTAAGAAACTTCAGCTTT
CAAGGGTTAGGAAACGGTTTTTTGGTGGATTTTAAAGATTCTCGCGACAAAAACTTAGCT
GTTTTTAAGTTAGGCGATGTTAGAAATTACAAAATTTCCAATTTTACCATTGATGATAAT
AAAACGATATTTGCCTCAATTTTAGTGGACGTAACAGAACGTAATGGGCGGTTACATTGG
TCGCGTAATGGAATTATCGAAAGAATAAAACAAAATAACGCTTTGTTCGGCTACGGCCTT
ATTCAAACCTATGGCGCAGATAATATTTTGTTTAGGAACCTCCATTCGGAAGGCGGAATT
GCGTTACGGATGGAAACTGACAACTTACTTATGAAAAATTATAAGCAAGGCGGAATAAGA
AACATCTTTGCTGATAATATCAGATGTAGCAAAGGACTTGCGGCGGTCATGTTTGGCCCA
CATTTTATGAAGAATGGAGATGTGCAAGTGACCAATGTCAGCTCAGTTAGTTGCGGTTCG
GCTGTACGAAGTGATAGTGGATTTGTCGAACTCTTTAGCCCGACAGACGAAGTACATACG
CGTCAAAGTTGGAAACAAGCCGTTGAAAGTAAATTGGGCCGAGGGTGTGCGCAAACCCCT
TATGCTAGAGGTAATGGTGGTACACGGTGGGCGGCTCGCGTAACACAAAAAGACGCGTGT
TTAGATAAAGCAAAACTGGAATATGGAATAGAGCCTGGTTCATTTGGCACGGTTAAAGTC
TTTGATGTTACAGCGCGTTTTGGTTATAACGCAGATCTTAAACAGGACCAGCTAGACTAC
TTTTCTACATCCAACCCTATGTGCAAGCGTGTATGCCTTCCTACAAAAGAACAATGGAGT
AAGCAAGGCCAAATTTACATTGGTCCGTCATTAGCTGCAGTAATTGATACCACACCTGAA
ACTTCAAAATACGATTATGATGTGAAAACTTTTAACGTCAAAAGAATAAATTTTCCTGTA
AATTCACACAAGACTATCGACACGAATACTGAAAGTAGCCGTGTCTGCAATTATTACGGT
ATGTCCGAATGCTCCAGCAGTCGATGGGAGCGATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9F5I8
UniProtKB Entry NameCGIA_ALTFO
GenBank Gene IDAJ272076
PDB ID(s)1H80, 1KTW, 3LMW
General References
  1. Barbeyron T, Michel G, Potin P, Henrissat B, Kloareg B: iota-Carrageenases constitute a novel family of glycoside hydrolases, unrelated to that of kappa-carrageenases. J Biol Chem. 2000 Nov 10;275(45):35499-505. [Article]
  2. Jouanneau D, Boulenguer P, Mazoyer J, Helbert W: Enzymatic degradation of hybrid iota-/nu-carrageenan by Alteromonas fortis iota-carrageenase. Carbohydr Res. 2010 May 7;345(7):934-40. doi: 10.1016/j.carres.2010.02.014. Epub 2010 Feb 19. [Article]
  3. Michel G, Chantalat L, Fanchon E, Henrissat B, Kloareg B, Dideberg O: The iota-carrageenase of Alteromonas fortis. A beta-helix fold-containing enzyme for the degradation of a highly polyanionic polysaccharide. J Biol Chem. 2001 Oct 26;276(43):40202-9. Epub 2001 Aug 7. [Article]
  4. Michel G, Helbert W, Kahn R, Dideberg O, Kloareg B: The structural bases of the processive degradation of iota-carrageenan, a main cell wall polysaccharide of red algae. J Mol Biol. 2003 Nov 28;334(3):421-33. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Iota-carrageenase (Alteromonas fortis)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
3,6-Anhydro-2-(hydrogen sulfate)-alpha-D-galactopyranoseexperimentalunknowntargetDetails