Polyprenol reductase
Details
- Name
- Polyprenol reductase
- Synonyms
- 1.3.1.94
- 3-oxo-5-alpha-steroid 4-dehydrogenase 3
- S5AR 3
- SR type 3
- SRD5A2L
- Steroid 5-alpha-reductase 2-like
- Steroid 5-alpha-reductase 3
- Gene Name
- SRD5A3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013344|Polyprenol reductase MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK SKFVSYPKHRKAFLPFLF
- Number of residues
- 318
- Molecular Weight
- 36521.005
- Theoretical pI
- Not Available
- GO Classification
- Functions3-oxo-5-alpha-steroid 4-dehydrogenase activity / cholestenone 5-alpha-reductase activity / oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor / polyprenol reductase activityProcessesandrogen biosynthetic process / dolichol metabolic process / dolichol-linked oligosaccharide biosynthetic process / dolichyl diphosphate biosynthetic process / polyprenol catabolic process / protein glycosylationComponentsendoplasmic reticulum / endoplasmic reticulum membrane / integral component of membrane
- General Function
- Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
- Specific Function
- 3-oxo-5-alpha-steroid 4-dehydrogenase activity
- Pfam Domain Function
- Steroid_dh (PF02544)
- Transmembrane Regions
- 12-34 81-101 118-138 158-178 195-215 261-281
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0013345|Polyprenol reductase (SRD5A3) ATGGCTCCCTGGGCGGAGGCCGAGCACTCGGCGCTGAACCCGCTGCGCGCGGTGTGGCTC ACGCTGACCGCCGCCTTCCTGCTGACCCTACTGCTGCAGCTCCTGCCGCCCGGCCTGCTC CCGGGCTGCGCGATCTTCCAGGACCTGATCCGCTATGGGAAAACCAAGTGTGGGGAGCCG TCGCGCCCCGCCGCCTGCCGAGCCTTTGATGTCCCCAAGAGATATTTTTCCCACTTTTAT ATCATCTCAGTGCTGTGGAATGGCTTCCTGCTTTGGTGCCTTACTCAATCTCTGTTCCTG GGAGCACCTTTTCCAAGCTGGCTTCATGGTTTGCTCAGAATTCTCGGGGCGGCACAGTTC CAGGGAGGGGAGCTGGCACTGTCTGCATTCTTAGTGCTAGTATTTCTGTGGCTGCACAGC TTACGAAGACTCTTCGAGTGCCTCTACGTCAGTGTCTTCTCCAATGTCATGATTCACGTC GTGCAGTACTGTTTTGGACTTGTCTATTATGTCCTTGTTGGCCTAACTGTGCTGAGCCAA GTGCCAATGGATGGCAGGAATGCCTACATAACAGGGAAAAATCTATTGATGCAAGCACGG TGGTTCCATATTCTTGGGATGATGATGTTCATCTGGTCATCTGCCCATCAGTATAAGTGC CATGTTATTCTCGGCAATCTCAGGAAAAATAAAGCAGGAGTGGTCATTCACTGTAACCAC AGGATCCCATTTGGAGACTGGTTTGAATATGTTTCTTCCCCTAACTACTTAGCAGAGCTG ATGATCTACGTTTCCATGGCCGTCACCTTTGGGTTCCACAACTTAACTTGGTGGCTAGTG GTGACAAATGTCTTCTTTAATCAGGCCCTGTCTGCCTTTCTCAGCCACCAATTCTACAAA AGCAAATTTGTCTCTTACCCGAAGCATAGGAAAGCTTTCCTACCATTTTTGTTTTAA
- Chromosome Location
- 4
- Locus
- 4q12
- External Identifiers
Resource Link UniProtKB ID Q9H8P0 UniProtKB Entry Name PORED_HUMAN HGNC ID HGNC:25812 - General References
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- Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H: Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci. 2008 Jan;99(1):81-6. Epub 2007 Nov 6. [Article]
- Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG: SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell. 2010 Jul 23;142(2):203-17. doi: 10.1016/j.cell.2010.06.001. Epub 2010 Jul 15. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB13943 Testosterone cypionate approved no substrate Details DB13944 Testosterone enanthate approved no substrate Details DB01420 Testosterone propionate approved, investigational, vet_approved, withdrawn no substrate Details DB13946 Testosterone undecanoate approved, investigational no substrate Details DB00717 Norethisterone approved unknown substrate Details