Reaction: Irinotecan to 1 product

Reaction
Irinotecan
DB00762
NPC
DBMET01681
Reaction type
oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Ramesh M, Ahlawat P, Srinivas NR: Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. doi: 10.1002/bmc.1345. [Article]
  2. Rothenberg ML: Irinotecan (CPT-11): recent developments and future directions--colorectal cancer and beyond. Oncologist. 2001;6(1):66-80. doi: 10.1634/theoncologist.6-1-66. [Article]
Comments
NPC is a weak topoisomerase I inhibitor.
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableimplied
Cytochrome P450 3A5Not AvailableNot Availableimplied