Reaction: Raloxifene to 3 products
Raloxifene is converted to Raloxifene-4′-glucuronide, Raloxifene-6, 4′-diglucuronide, and Raloxifene-6-glucuronide by UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A8, and UDP-glucuronosyltransferase 1A1.
- Reaction
- Direction
- Activity
- inactive
- Comments
- Correlation analyses revealed that UGT1A1 was responsible for 6-beta- but not 4'-beta-glucuronidation in liver. [A178939]
What you can answer from here — as of May 17, 2019
3EnzymesEach linked to its target cardListed above
Which other drugs are metabolised by UDP-glucuronosyltransferase 1A10, UDP-glucuronosyltransferase 1A8, and UDP-glucuronosyltransferase 1A1, and which of those pairings are clinically significant?
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