Reaction: Raloxifene to 3 products
- Reaction
- Reaction type
- glucuronidation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- inactive
- References
- Sun D, Jones NR, Manni A, Lazarus P: Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. Cancer Prev Res (Phila). 2013 Jul;6(7):719-30. doi: 10.1158/1940-6207.CAPR-12-0448. Epub 2013 May 16. [Article]
- Kemp DC, Fan PW, Stevens JC: Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Drug Metab Dispos. 2002 Jun;30(6):694-700. [Article]
- Comments
- Correlation analyses revealed that UGT1A1 was responsible for 6-beta- but not 4'-beta-glucuronidation in liver. [A178939]
- Enzymes
Enzyme Km Vmax Role UDP-glucuronosyltransferase 1-10 Not Available Not Available confirmed UDP-glucuronosyltransferase 1-8 Not Available Not Available confirmed UDP-glucuronosyltransferase 1-1 Not Available Not Available confirmed