Reaction: Raloxifene to 3 products

Reaction
Reaction type
glucuronidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
inactive
References
  1. Sun D, Jones NR, Manni A, Lazarus P: Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. Cancer Prev Res (Phila). 2013 Jul;6(7):719-30. doi: 10.1158/1940-6207.CAPR-12-0448. Epub 2013 May 16. [Article]
  2. Kemp DC, Fan PW, Stevens JC: Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Drug Metab Dispos. 2002 Jun;30(6):694-700. [Article]
Comments
Correlation analyses revealed that UGT1A1 was responsible for 6-beta- but not 4'-beta-glucuronidation in liver. [A178939]
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-10Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-8Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-1Not AvailableNot Availableconfirmed