UDP-glucuronosyltransferase 1A8

BE0003682ProteinHumansUGT1A8

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:16595710, PubMed:18004212,... It is acted on by 26 drugs in DrugBank.

Gene name
UGT1A8
UniProtKB entry
Q9HAW9Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
530 residues · 59,741 Da
Also known as
2.4.1.17 · GNT1 · UDP-glucuronosyltransferase 1-8 · UDP-glucuronosyltransferase 1-H · UDPGT 1-8

Resolves to

Protein
UniProtQ9HAW9UniProt nameUD18_HUMAN
Gene
HGNCHGNC:12540NCBI Gene54576GenBank2613044GeneCardsUGT1A8
Pharmacology
KEGGhsa:54576
Drugs

What you can answer from here — as of September 03, 2024

26DrugsApproved to experimental, with action, bond type and pharmacological action
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29Metabolic reactionsDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A8, how selective are they, and which programs against it are still in active trials?

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