UDP-glucuronosyltransferase 1A10

BE0003678ProteinHumansUGT1A10

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:18004212, PubMed:18052087,... It is acted on by 20 drugs in DrugBank.

Gene name
UGT1A10
UniProtKB entry
Q9HAW8Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
530 residues · 59,809 Da
Also known as
2.4.1.17 · GNT1 · UDP-glucuronosyltransferase 1-10 · UDP-glucuronosyltransferase 1-J · UDPGT 1-10

Resolves to

Protein
UniProtQ9HAW8UniProt nameUD110_HUMAN
Gene
HGNCHGNC:12531NCBI Gene54575GenBank2039362GeneCardsUGT1A10
Pharmacology
KEGGhsa:54575
Drugs

What you can answer from here — as of September 03, 2024

20DrugsApproved to experimental, with action, bond type and pharmacological action
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17Metabolic reactionsDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 1A10, how selective are they, and which programs against it are still in active trials?

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