Reaction: Hydrocortisone to 1 product

Reaction
Reaction type
oxidation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Finken MJ, Andrews RC, Andrew R, Walker BR: Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases. J Clin Endocrinol Metab. 1999 Sep;84(9):3316-21. doi: 10.1210/jcem.84.9.6009. [Article]
  2. Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR: Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Corticosteroid 11-beta-dehydrogenase isozyme 1Not AvailableNot Availableimplied
Corticosteroid 11-beta-dehydrogenase isozyme 2Not AvailableNot Availableimplied