11-beta-hydroxysteroid dehydrogenase type 2

BE0000131ProteinHumansHSD11B2

Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:10497248, PubMed:12788846, PubMed:17314322, PubMed:22796344, PubMed:23685396, PubMed:27927697, PubMed:30902677, PubMed:33387577, PubMed:7859916, PubMed:8538347). It is acted on by 19 drugs in DrugBank.

Gene name
HSD11B2
UniProtKB entry
P80365Swiss-Prot
Cellular location
Microsome
Residues / weight
405 residues · 44,126 Da
Also known as
1.1.1.- · 11-beta-HSD type II · 11-beta-HSD2 · 11-beta-hydroxysteroid dehydrogenase type II · 11-DH2

Resolves to

Protein
UniProtP80365UniProt nameDHI2_HUMAN
Gene
HGNCHGNC:5209NCBI Gene3291GenBank565082GeneCardsHSD11B2
Pharmacology
IUPHAR/GtoPdb3143KEGGhsa:3291
Drugs

What you can answer from here — as of September 03, 2024

19DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 11-beta-hydroxysteroid dehydrogenase type 2, how selective are they, and which programs against it are still in active trials?

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