Cortisone

DB14681InvestigationalSmall moleculeCorticosteroids

A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to... It is converted in the liver to the active metabolite hydrocortisone.

Chemical structure of Cortisone
Mechanism
Curator reviewed
Formula / weight
C21H28O5 · 360.444 g/mol (avg)
Also known as
Kendall's compound E · Kortison · Reichstein's substance Fa

Resolves to

Compound
UNIIV27W9254FZCAS53-06-5ChEMBLCHEMBL1499ChEBI16962KEGGD07749
Clinical / RWD
RxNorm2878ATCH02AB10ATCS01BA03
Structure
InChIKeyMFYSYFVPBJMHGN-ZPOLXVRWSA-NSMILES[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Targets
P04054PLA2G1B

What you can answer from here — as of July 10, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
976Drug interactionsStructured to mechanism, not free text
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139Clinical trialsPhase, status and sponsor resolved per trial
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2Marketed productsAcross 2 countries and 2 labellers
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2ATC codesIncluding every combination product, plus 24 drug categories
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14+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Cortisone, and which of those have an active Phase 3 trial?

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