This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Cortisone
- DrugBank Accession Number
- DB14681
- Background
A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite hydrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Cortisone (DB14681)
- Weight
- Average: 360.444
Monoisotopic: 360.193674006 - Chemical Formula
- C21H28O5
- Synonyms
- 11-dehydro-17-hydroxycorticosterone
- 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
- 17α,21-dihydroxy-4-pregnene-3,11,20-trione
- 4-pregnene-17α,21-diol-3,11,20-trione
- Cortisona
- Cortisone
- Cortisonum
- Kendall's compound E
- Kortison
- pregn-4-en-17α,21-diol-3,11,20-trione
- Reichstein's substance Fa
- Wintersteiner's compound F
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbemaciclib The metabolism of Abemaciclib can be increased when combined with Cortisone. Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Cortisone. Acarbose The risk or severity of hyperglycemia can be increased when Cortisone is combined with Acarbose. Aceclofenac The risk or severity of gastrointestinal irritation can be increased when Cortisone is combined with Aceclofenac. Acemetacin The risk or severity of gastrointestinal irritation can be increased when Cortisone is combined with Acemetacin. Acenocoumarol Cortisone may increase the anticoagulant activities of Acenocoumarol. Acetohexamide The risk or severity of hyperglycemia can be increased when Cortisone is combined with Acetohexamide. Acetyldigitoxin The risk or severity of adverse effects can be increased when Cortisone is combined with Acetyldigitoxin. Acetylsalicylic acid The risk or severity of adverse effects can be increased when Cortisone is combined with Acetylsalicylic acid. Adenovirus type 7 vaccine live The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Cortisone. 
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- Not Available
Products
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Categories
- ATC Codes
- H02AB10 — Cortisone
- H02AB — Glucocorticoids
- H02A — CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- H02 — CORTICOSTEROIDS FOR SYSTEMIC USE
- H — SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
- Drug Categories
- 17-Hydroxycorticosteroids
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Corticosteroid Hormone Receptor Agonists
- Corticosteroids
- Corticosteroids for Systemic Use
- Corticosteroids for Systemic Use, Plain
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 CYP3A4 Inducers
- Cytochrome P-450 CYP3A4 Inducers (strength unknown)
- Cytochrome P-450 CYP3A5 Inducers
- Cytochrome P-450 CYP3A5 Inducers (strength unknown)
- Cytochrome P-450 Enzyme Inducers
- Fused-Ring Compounds
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Hydroxycorticosteroids
- Ophthalmologicals
- Pregnanes
- Pregnenes
- Sensory Organs
- Steroids
- Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- V27W9254FZ
- CAS number
- 53-06-5
- InChI Key
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N
- InChI
- InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
- IUPAC Name
- (1R,3aS,3bS,9aR,9bS,11aS)-1-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7,10-dione
- SMILES
- [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0002802
- KEGG Drug
- D07749
- KEGG Compound
- C00762
- ChemSpider
- 193441
- BindingDB
- 13739
- 2878
- ChEBI
- 16962
- ChEMBL
- CHEMBL1499
- ZINC
- ZINC000004083557
- Wikipedia
- Cortisone
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral 25 MG Suspension 25 mg/1ml - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.136 mg/mL ALOGPS logP 1.98 ALOGPS logP 1.66 ChemAxon logS -3.4 ALOGPS pKa (Strongest Acidic) 12.58 ChemAxon pKa (Strongest Basic) -3.3 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 5 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 91.67 Å2 ChemAxon Rotatable Bond Count 2 ChemAxon Refractivity 96.47 m3·mol-1 ChemAxon Polarizability 38.95 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Oxygen binding
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP3A5
- Uniprot ID
- P20815
- Uniprot Name
- Cytochrome P450 3A5
- Molecular Weight
- 57108.065 Da
References
- Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
Drug created at September 05, 2018 18:17 / Updated at July 03, 2021 01:49