Reaction: Fenfluramine to 1 product

Reaction
Reaction type
N-deethylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Smith DA, Obach RS, Williams DP, Park BK: Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity. Chem Biol Interact. 2009 Apr 15;179(1):60-7. doi: 10.1016/j.cbi.2008.09.022. Epub 2008 Sep 26. [PubMed:18930037]
  2. Haritos VS, Ching MS, Ghabrial H, Gross AS, Taavitsainen P, Pelkonen O, Battaglia SE, Smallwood RA, Ahokas JT: Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2. Pharmacogenetics. 1998 Oct;8(5):423-32. [PubMed:9825834]
  3. FDA Approved Drug Products: Fintepla (fenfluramine) oral solution [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2D6Not AvailableNot Availableconfirmed
Cytochrome P450 1A2Not AvailableNot Availableconfirmed