Reaction: Nevirapine to 1 product
- Reaction
- Reaction type
- 8-hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- unknown
- References
- Riska P, Lamson M, MacGregor T, Sabo J, Hattox S, Pav J, Keirns J: Disposition and biotransformation of the antiretroviral drug nevirapine in humans. Drug Metab Dispos. 1999 Aug;27(8):895-901. [Article]
- Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 2D6 Not Available Not Available confirmed Cytochrome P450 2B6 Not Available Not Available confirmed Cytochrome P450 3A4 Not Available Not Available confirmed