Cytochrome P450 2B6

BE0003549ProteinHumansCYP2B6

A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:12865317, PubMed:21289075). It is acted on by 255 drugs in DrugBank.

Gene name
CYP2B6
UniProtKB entry
P20813Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
491 residues · 56,278 Da
Also known as
1,4-cineole 2-exo-monooxygenase · 1.14.13.- · CYPIIB6 · Cytochrome P450 IIB1

Resolves to

Protein
UniProtP20813UniProt nameCP2B6_HUMAN
Gene
HGNCHGNC:2615NCBI Gene1555GenBank181296GeneCardsCYP2B6
Pharmacology
IUPHAR/GtoPdb1324KEGGhsa:1555
Structure
PDB3IBDPDB3QOAPDB3QU8
Drugs

What you can answer from here — as of September 07, 2019

255DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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113Metabolic reactionsDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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488+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2B6, how selective are they, and which programs against it are still in active trials?

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